| Project/Area Number |
08457291
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Iwate Medical University |
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Principal Investigator |
CHIDA Shoichi Iwate Medical University Department of Pediatrics, Professor, 医学部, 教授 (30108930)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Akio Iwate Medical University the medical department Instractor, 医学部, 講師 (70163235)
SHIMADA Senji Iwate Medical University the medical department assistant profess, 医学部, 助教授 (30091804)
小西 峯生 岩手医科大学, 医学部, 講師 (60143062)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥7,400,000 (Direct Cost: ¥7,400,000)
Fiscal Year 1998: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥5,100,000 (Direct Cost: ¥5,100,000)
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| Keywords | chronic lung disease / cytokines / elastase / pulmonary surfactant / 肺サーファクタント蛋白 |
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| Research Abstract |
To determine if release of inflammatory mediators into the airways or abnormality of pulmonary surfactant is associated with later development of chronic lung disease (CLD), we measured concentrations of interleukin-6 (IL-6), IL-8, tumor necrosis factor a (TNF- alpha), granulocyte elastase, surfactant proteins (SF-A and SP-B,C), and stable tnicrobubble count in tracheal aspirates from 121 infants weighing less than 1500 g who required mechanical ventilation.
The concentrations of IL-8 and elastase in infants who subsequently developed CLD (n=23) were significantly higher than those in infants without CLD (n = 98) at 1, 3, 4 and 5 days of age. CLD group had significantly higher level of TNF- alpha at 21 days of age. Multiple logistic regression analysis revealed that factors affecting the development of CLD during the first 5 days of age were increased levels of IL-8 and elastase in tracheal aspirates, and the severity of lung disease.
These results indicate that IL-8, elastase and TNF-alpha play important roles in the development of CLD.
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