| Project/Area Number |
08457297
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | SHINSHU UNIVERSITY,SCHOOL OF MEDICINE |
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Principal Investigator |
HASHIKURA Yasuhiko SHINSHU UNIVERSITY,SCHOOL OF MEDICINE,ASSISTANT PROFESSOR, 医学部附属病院, 講師 (10228398)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASAKI Seiji SHINSHU UNIVERSITY,SCHOOL OF MEDICINE,PROFESSOR, 医学部, 教授 (80177667)
橋倉 泰彦 信州大学, 医学部附属病院, 講師 (10228398)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1997: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1996: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | LIVER TRANSPLANTATION / HEPATIC ARTERY THROMBOSIS / COAGULATION-FIBRINOLYTIC SYSTEM |
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| Research Abstract |
HEPATIC ARTERY THROMBOSIS AFTER ORTHOTOPIC LIVER TRANSPANTATION IS A SERIOUS COMPLICATION.WE HAVE DEVELOPED AN INTENSIVE ANTICOAGULANT THERAPY DURING AND AFTER LIVING-RELATED LIVER TRANSPLANTATION IN PEDIATRIC RECIPIENTS.EIGHTY-FOUR PATIENTS BETWEEN 5 MONTHS AND 60 YEARS OF AGE UNDER WENT LIVING-RELATED LIVER TRANSPLANTATION.THE MEAN DIAMETER OF THE ANASTOMOSED HEPATIC ARTERIES WAS 2.7 MM.THE ANTICOAGULANT THERAPY CONSISTED OF LOW MOLECULAR WEIGHT HEPARIN,ANTITHEROMBIN III CONCENTRATES,PROSTAGLANDIN E_1, FRESH FROZEN PLASMA AND A PROTEASE INHIBITOR.THE PROFILES OF THE COAGULATION AND FIBRINOLYTIC SYSTEMS WERE MONITORED BY MEASURING SEVERAL PARAMETERS,INCLUDING PLASMA LEVELS OF THROMBIN-ANTITHROMBIN III COMPLEX,ANTITHROMBIN III,PLASMIN-alpha 2 PLASMIN INHIBITOR COMPLEX,FIBRIN DEGRADATION PRODUCT D-DIMER,TISSUE TYPE-PLASMINOGEN ACTIVATOR AND PLASMINOGEN ACTIVATOR INHIBITOR-1. ACCELERATION OF THE COAGULATION SYSTEM AND DELAYED BECOVERY OF THE FIBRINOLYTIC SYSTEM WERE OBSERVED DURING THE EARLY POSTOPERATIVE DAYS.THE PLASMA LEVEL OF ANTITHROMBIN III ACTIVITY WAS MAINTAINED WITHIN THE NORMAL RANGE BY THE ADMINISTRATION OF ANTITHROMBIN III CONCENTRATES.NONE OF THE RECIPIENTS DEVELOPED HEPATIC ARTERY THROMBOSIS.WE BELIEVE THAT THE INTENSIVE ANTICOAGULATION THERAPY DEVELOPED IN THIS STUDY,THE MAIN CONCEPT OF WHICH ISTHE EARLY CORRECTION OF IMBALANCE BETWEEN THE COAGULANT AND ANTICOAGULANT SYSTEMS,COULD BECOME A MODEL FOR THE PREVENTION OF HEPATIC ARTERY THROMBOSIS IN PEDIA TRIC LIVER TRANSPLANTATION PATIENTS.
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