| Project/Area Number |
08457345
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Gunma University School of Medicine |
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Principal Investigator |
MORISHITA Yasuo Gunma University School of Medicine, Second Department of Surgery, Professor and Chairmen, 医学部, 教授 (40145470)
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| Co-Investigator(Kenkyū-buntansha) |
SAKATA Kazuhiro Gunma University School of Medicine, Second Department of Surgery, Assistant, 医学部, 助手 (10302473)
ISHIKAWA Susumu Gunma University School of Medicine, Second Department of Surgery, Assistant Pro, 医学部, 講師 (90241877)
大滝 章男 群馬大学, 医学部, 助手 (80241876)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥8,100,000 (Direct Cost: ¥8,100,000)
Fiscal Year 1998: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1996: ¥3,900,000 (Direct Cost: ¥3,900,000)
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| Keywords | simple immersion / soronary perfusion / heart preservation / heart transplantation / cardiac function / force transducer / 単純浸漬保存 / 冠灌流保存 |
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| Research Abstract |
In our previous study, the donor heart was well preserved by the combined method of 12-hr simple immersion and 1-hr coronary perfusion. The efficacy of diluted blood was confirmed as perfusate for coronary perfusion compared with the University of Wisconsin (UW) solution. In addition, we designed an original apparatus for continuous coronary perfusion preservation instead of the Langendorff's method This apparatus has such characteristics as hypothermic management, variable perfusion pressure, non-dependent energy source and portable. We reported the usefulness of this apparatus in canine models through 12-hr preservation followed by orthotopic transplantation. We are now planning the evaluation of transplanted hearts by the force transducer and long-term heart preservation of more than 12-hr.
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