| Project/Area Number |
08457355
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
SAWAMURA Yutaka Hosp., Hokkaido Univ., Lecturer, 医学部・附属病院, 講師 (10235476)
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| Co-Investigator(Kenkyū-buntansha) |
TADA Mitsuhiro Sch.of Med., Hokkaido Univ., Assistant, 医学部, 助手 (10241316)
加藤 功 北海道大学, 医学部, 助手 (50271664)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1998: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1997: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1996: ¥6,000,000 (Direct Cost: ¥6,000,000)
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| Keywords | p53 / genetic diagnosis / yeast p53 functional assay / astrocytoma / glioblastoma / brain tumor / prognosis / gene diagnosis |
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| Research Abstract |
This project has yielded a considerable amount of results as follows.
1) Analysis of astrocytomas, where matching tumor material and derived cell lines were available, demonstrated a clonal expansion of p53 mutated clone, supporting the hypothesis of clonal progression of brain tumors in vivo (Int J Cancer 1996).
2) Application of the assay on anaplastic astrocytomas and glioblastomas demonstrated a higher ratio of p53 mutation in anaplastic astrocytomas (67%) than in glioblastomas (43%), indicating that that many glioblastomas develop by p53-independent pathways (Mol Carcinog 1997).
3) Analysis of clinicopathological parameters in patients with glioblastomas demonstrated that p53 mutation is a marker for better radiation response in glioblastomas and this results in significantly longer survival (Cancer Res 1998)
4) Application of the assay to non-astrocytic brain tumors demonstrated that p53 mutation is rare event except in primary malignant lymphomas (Acta Neuropathol 1998).
5) Analysis of pilocytic astrocytomas demonstrated that p53 mutation is rare in these tumors (Int J Cancer 1998).
6) By summarizing the above results, we have published several
review articles, including a chapter in a book.
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