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Basic and Clinical Study of Morphological and Functional Changes in Brainstem and Cerebellum in the Cases with Disturbances in Dynamics of Cerebrospinal Fluid Circulation

Research Project

Project/Area Number 08457365
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKobe University

Principal Investigator

TAMAKI Norihiko  Kobe University School of Medicine, Department of Neurosurgery, professor, 医学部, 教授 (10030941)

Co-Investigator(Kenkyū-buntansha) EHARA Kazumasa  Kobe University School of Medicine, Department of Neurosurgery, assistant profes, 医学部, 助教授 (20151996)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1998: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1997: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1996: ¥2,800,000 (Direct Cost: ¥2,800,000)
KeywordsNPH / circulation of CSF / function of brain stem and cerebellum / MRI / ventriculomegaly / ventriculo-peritoneal shunt / cerebral blood flow / 脳脊髄液 / 大脳高次機能 / 髄液短絡術 / 脳室-腹腔短絡術
Research Abstract

Perioperatively intelligence tests were performed in fourteen cases (mean age of 74.8 years) that were diagnosed normal pressure hydrocephalus. Criteria for shunts were, 1) mar than two of trias of NPH, 2) ventriculomegaly, 3) IIIb-V in CTC, 4) rate of B-wave was more than 35% in ICP monitoring, 5) not high risk of operation and general anesthesia. All cases were performed shunts. Surgical results of intelligence tests were good in four cases, fair in four cases, no change in four cases and deteriorated in two cases.
CT, MRI, CT cisternography, and cerebral blood flow measurement were analyzed in seven cases (mean age of 66 years) of normal pressure hydrocephaly. V-P shunts were performed in all ases. Postopretave symptoms were improved in five cases. There were tendencies of improvement after sugical treatments in cases which had severe ventriculomegaly, low CBF in periventricular white matter and cortex of frontal lobe, and higher frequency of abnormal waves in ICP monitoring.
We performed a retrospective study in 124 patients (mean age of 35.5 years) of hydrocephalus. Forty-five patients were performed only single shunt operations. Forty-nine patients required the revisions of their shunts. The postoperative symtopms were improved in some cases even if they didn't fill the criteria of CTC or ICP monitoring test. Further investigation is required in analyzing clinical symptom with cerebrospinal fluid dynamic test in decision making for shunt operation.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] 玉木 紀彦: "正常圧水頭症" 老年期痴呆. 12・1. 45-57 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 玉木 紀彦: "髄液循環の臨床" 神経内科. 48・1. 7-13 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Chakrabortty S: "Experimental syringomyelia: Late ultrastructural changes of spinal cord tissue and magnetic resonance imaging evaluation" Surgical Neurology. 48・2. 246-254 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 倉田 浩充: "高齢者の正常圧水頭症" Geriatric Neurosurgery. 8. 125-128 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 玉木 紀彦: "癒着性脊髄クモ膜炎と脊髄空洞症" 日独医報. 41(2). 83-94 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamaki N,Nagashima T: "Hydrodynamics of syringomyelia" Clin Neurol. 35 (12). 1398-1399 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kurata H,Tamaki N,Nagashima T: "Normal Pressure hydrocephalus in aged patients" Ceriatric Neurosurgery. 8. 125-128 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamaki N,Takahashi A,Nagashima T: "Adhesive spinal arachnoiditis and syringomyelia" Japanisch-Deutsche Mediizinische Brrichte. 41 (2). 83-94 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nagashima T,Tamaki N: "Imaging diagnosis of syringomyelia and anomalies in craniovertebral junction" J of Spine and Spinal Cord. 10 (4). 333,340 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Chakrabortty S,Tamaki N Ide C,Ehara K: "Experimental syringomyelia : Late ultrastructural changes of spinal cord" Surgical Neurology. 48・2. 246-254 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamaki N,Ehara K: "Clinical aspect of cerebrospinal fluid circulation" Clin Neurol. 48 (1). 7-13 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Morishita A,Eguchi T,Tamaki N: "Accidental resetting of the Medos programmable pressure vulve indicator caused by a laudspeaker" Nervous system in children. 23 (2). 109-112 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kawaguchi T,Fujita S,Tamaki N: "Treatment od subdural effusion with hydrocephalus after ruptured intracranial aneurysm cliipping" Neurosurg. 43 (5). 1033-1039 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamaki N,Kojima N: "Normal pressure hydrocephalus (NPH)" J of Senile Dementia. 12 (1). 45-56 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamaki N: Normal pressure hydrocephalus Tamaki N : Quantitative cerebral blood flow measurements using Xe CT. Futura Pub Co., NY 1995, 311-319

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 玉木紀彦: "正常圧水頭症" 老年期痴呆. 12・1. 45-57 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 玉木紀彦: "髄液循環の臨床" 神経内科. 48・1. 7-13 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Chakraborccy S: "Experimental syringomyelia : Late ultrastructural changes of spinal cord" Surgical Neurology. 48・2. 246-254 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 倉田浩充: "高齢者の正常圧水頭症" Genatric Neurosurgery. 8. 125-128 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] 玉木紀彦: "癒着性脊髄クモ膜炎と脊髄空洞症" 日独医報. 41(2). 83-94 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] 玉木紀彦: "脊髄空洞症の髄液循環動態" 臨床神経学. 35(12). 1398-1399 (1995)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tamaki N: "Quantitative Cerebral Blood Flow Measurements using XeCT" Tourouaga M.Tanaka A,Yomas H, 354 (1995)

    • Related Report
      1998 Annual Research Report
  • [Publications] Chakrabortyee S: "Experimental syringomyelia : Late ultrastructural changes of spinal cord" Surgical Neurology. 48・2. 246-254 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 玉木紀彦: "正常圧水頭症" 老年期痴呆. 12・1. 45-57 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 玉木紀彦: "髄液循環の臨床" 神経内科. 48・1. 7-13 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 玉木紀彦、長嶋達也: "骨髄空洞症の髄液循環動態" 臨床神経学. 35(12). 1398-1399 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 倉田浩充、玉木紀彦、長嶋達也: "高齢者の正常圧水頭症" Geriatic Neurosurgery. 8. 125-128 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 玉木紀彦、高橋歩、長嶋達也: "癒着性脊髄クモ膜炎と脊髄空洞症" 日独医報. 41(2). 83-94 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tamaki N: "Quantitative Cerebral Blood Flow Measurements using XeCT" Tomonaga M,Tanaka A,Yonas H, 354 (1995)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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