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Transplantation of cervical sympathetic ganglion into the brain with Parkinson's disease

Research Project

Project/Area Number 08457372
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionWakayama Medical College

Principal Investigator

ITAKURA Toru  Wakayama Medical College Neurological Surgery Professor and Chairman, 医学部, 教授 (40100995)

Co-Investigator(Kenkyū-buntansha) UEMATSU Yuji  Wakayama Medical College Neurological Surgery Assistant Professor, 医学部, 助手 (90223502)
NAKAI Kunio  Wakayama Medical College Neurological Surgery Associate Professor, 医学部, 助教授 (20180234)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 1997: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1996: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsParkinson's disease / neural transplantation / free radical / sympathetic ganglion / free radical
Research Abstract

We have investigated the effect of transplantation of autologous sympathetic ganglion into the brain with Parkinson's disease. Base on encouraging data obtained from experimental studies, we have clincally applied this new therapeutic modality for 50 patients with Parkinson's disease. In this project we have demonstrated that free radical interfered the survival of the graft and free radical inhibitor enhanced survival rate and functional recovery of transplanted animals. In the clinical study, we have revealed that half the patients showed amelioration of gait and movement in the patients for 5-6 years after transplantation. In contrast, the rest of half patients did not show improvement of the symptoms even after the transplantation. Influencing factors for outcome of the patients were duration of the disease and severity of symptoms. The present stud suggests that administration of free radical inhibitors may enhance the effects of sympathetic ganglion of parkinsonian symptoms.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (41 results)

All Other

All Publications (41 results)

  • [Publications] 板倉 徹: "Parkinson病の外科的治療の現状と将来の展望" Geriatric Neurosurgery. 8. 11-18 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 板倉 徹: "パーキンソン病の外科治療" 脳障害と薬理. 2. 37-43 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Itakura T, Uematsu U Nakao N, Nakai E, Nakai K: "Transplantation of autologous sympathetic ganglion into the brain with Parkinson's disease.Long-tern follow-up of 35 cases." 11th International Congress of Neurological Surgery. 2025-2029 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakao N, P Brundin: "Effects of a-phenyl-tert-butyl nitrone on neuroral survival and motor function-following intrastriatal injections of quirolinic or 3-nitropropionic acid" Neuroscience. 76. 749-761 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M Barkats, Nakao N et al: "Intrastriatal grafts of embryonic mesencephalic rat cells genetically modified using an adenorirus encoding for the human Cu/Zn superoxide dismutase" Neuroscience. 78. 703-713 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakao N, Nakai K, Itakura T: "Metabolic inhibition enhances selective toxicity of L-DOPA tomard dopamine neurons in vitro." Brain Res. 777. 202-209 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 板倉 徹, 駒井 則彦, 中尾 直之: "神経の再生と機能再建" 西村書店, (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 上松 右二, 湯川 修也 大岩 美嗣, 板倉 徹: "神経移植における神経伝達物質とその受容体" Medical View, (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] ITAKURA T,et al.: "Neural Transplant" SASHIN NOGEKA. 95-101 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] ITAKURA T,et al.: "Transplant therapy for PArkinson's disease" Neural Reconstruction. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] UEMATSU Y,et al.: "Neurotransmitter and receptor in neural transplant" Neurtraansmitter and receptor in neural disease. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] NAKAI E et a.: "Stereotactic surgery" Neurosurgical Review. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] ITAKURA T,et al.: "Frontal Lobe" Neuroscience Exp & clin. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] ITAKURA T,et al.: "Stereotactic surgery and endovascular surgery" Rehabilitation Med. 33. 602-605 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] ITAKURA T,et al.: "Surgical therapy in Parkinson's disease" Geriatric Neurosurgery. 8. 11-18 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Itakura T,et al.: "Surgical therapy in Parkinson's disease" Brain Inhury Pharmoacol. 2. 37-43 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Itakura T,et al.: "Stereotactic open microsurgery for intraventricular tumors" 11th International Congress of Neurological Surgery. 2085-2089 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] ITAKURA T,et al.: "Transplantatiion of autologous sympathetic ganglion into the brain with Parkinson's disease. Long-tern follow-up of 35 cases" 11th International Congress of Neurological Surgery. 2025-2029 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] RO Kenpei: "Aneurysm associated with PArkinson's disease" Wakayama Med Soci. 48. 347-349 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] NAKAO N et al.: "Cell transplant in parkinsonism" Kinesis. 2. 11-14 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] OZAKI F et al.: "Deep brain stimulation" Molecular Medicine. 34. 102-104 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakao N: "Effects of alpha-phenyl-tert-butyl nitrone on neuronal survival and motor function following intrastriatal injections of quinolic or 3-nitroproic acid." Neuroscience. 76. 749-761 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Barkats Met al.: "Intrastriatal drafts of embryonic mesencephalic rat cells genetically modified using an adenovirus encoding for the human Cu/Zn superoxide dismutase." Neuroscience. 78. 703-713 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Grabon-Frodl EM et al.: "Developmental features of human striatal tissue transplanted in a rat model of Huntington's disease." Neurobiology of Disease. 4. 299-311 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Emgard-Mattson M: "Addition of lateral ganglionic eminence to rat mesencephalic grafts affects fiber outgrowth but does not enhance function." Cell Transplant. 6. 277-286 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakao N et al.: "Metabolic inhibition enhancedc selective toxicity of L-DOPA toward dopamine neurons in vitro." Brain Res. 777. 202-209 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 板倉 徹: "Parkinson病の外科的治療の現状と将来の展望" Geriatric Neurosurgery. 8. 11-18 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 板倉 徹: "パーキンソン病の外科治療" 脳障害と薬理. 2. 37-43 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Itakura T, Uematsu Y, Nakano N, Nakai E, Nakai K: "Transplantation of autologous sympathetic ganglion into the brain with Parkinson′s disease. Long-tern follow-up of 35 cases." 11th International Congress of Neurological Surgery. 2025-2029 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakao N, P Brudin: "Effect of a-phenyl-tert-butyl nitrone on neuronal survival and motor function-following intrastriatal injections of quinolinic or 3-nitropropionic acid." Neuroscience. 76. 749-761 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M Barkats, Nakao N etal: "Intrastriatal grafts of embryonic mesencephalic rat cells genetically modified using an adenorirus encoding for the human Cu/Zn superoxide dismutase" Neuroscience. 78. 703-713 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakao N, Nakai K, Itakura T: "Matabolic inhibition enhances selective toxicity of L-DOPA toward dopamine neurous in vitro." Brain Res. 777. 202-209 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 板倉 徹,駒井則彦,中尾直之: "神経の再生と機能再建" 西村書店, (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 上松右二,湯川修也,大岩美嗣,板倉 徹: "神経移植における神経伝達物質とその受容体" Medical View, (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] T. Itakura et al: Acta Neurochir. 133. 61-67 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 板倉徹: "神経組織の移植" Clinical Neuroscience. 13. 10-11 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] T Itakura et al: "Pretreatment with interleukin-1 ebhances of survical" Neurol Med Chir. 34. 407-411 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] T. Itakura: "Autologous transplantation of the cervical syupahetic ganglion into the parkinsonian brain : case report" Neurosurgery. 35. 155-158 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] 板倉徹: "頸部交感神経節の脳内移植" 脳外. 22. 199-205 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] 板倉徹: "脳を守る" ブレーン出版, 131 (1976)

    • Related Report
      1996 Annual Research Report
  • [Publications] 板倉徹: "前頭葉" ブレーン出版, 187 (1976)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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