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Proposal of a new clinical cyto-functional classification of pituitary adenomas

Research Project

Project/Area Number 08457375
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionNippon Medical School

Principal Investigator

TERAMOTO Akira  Nippon Medical School Department of Neurosurgery, Professor, 医学部, 教授 (60231445)

Co-Investigator(Kenkyū-buntansha) ADACHI Kohji  Nippon Medical School Department of Neurosurgery, Assistant Professor, 医学部, 講師 (00231928)
YOSHIDA Daizo  Nippon Medical School Department of Neurosurgery, Assistant Professor, 医学部, 講師 (30210701)
SHIMURA Toshiro  Nippon Medical School Department of Neurosurgery, Associate Professor, 医学部, 助教授 (90110973)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥7,400,000 (Direct Cost: ¥7,400,000)
Fiscal Year 1997: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1996: ¥6,300,000 (Direct Cost: ¥6,300,000)
KeywordsPituitary / Pituitary adenoma / mRNA / classification / transcriptional factor / hypothalamic hormone / receptor / nuclear receptor / pituitary adenoma / transcriptional factor / hypothalamic hormone / receptor / unclear receptor / 下垂体前葉ホルモン / Pit-1 / 免疫組織化学 / in situ hybridization / 病理分類
Research Abstract

Pituitary adenomas have been classified historically on the basis of tinctorial affinities, followed by the basis of ultrastructure and immunohistochemistry. The current development of technologies necessitate the new classification of pituitary adenomas which integrates these numerous informations as well as the clinical informations. For this purpose, we suggest a new clinical cytofunctional classification of pituitary adenomas, which is based on clinical manifestations and integrates the information on biology, images, function and ultrastructure. We have examined about 600 surgically obtained adenoma tissues by immunohistochemistry (IHC), in situ hybridization (ISH) and electronmicroscopy. By IHC and ultrastructural techniques, most GH-producing adenomas present multihormonal expressions and it has been suggested that pituitary specific transcriptional factor Pit-1 may have a role in the functional differentiation and the multihormonality of GH, TSH and PRL secreting adenomas. Clinically non-functioning adenomas have demonstrated gonadotropin secretion and the descrepancy between hormonal expression by IHC and gene expression by ISH.
Furthermore, we have investigated the expression of various transcripts including hypothalamic hormones, hypothalamic hormone receptors, estrogen receptor, retinoid X receptor, which regarded to have important eoles on tumorigenesis and cell differentiation, using in situ polymerase chain reaction. Introduction of the molecular biotechniques in clinical cyto-functional classification is expected to provide a better understanding of the pathogenesis, pathophysiologies and functions of pituitary adenomas.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (37 results)

All Other

All Publications (37 results)

  • [Publications] Sanno N, Teramoto A, et al.: "A growth hormone-releasing hormone-producing pancreatic islet cell tumor metastasized to pituitary is associated with pituitary somatotroph hyperplasia and acromegaly" J Clin Endocrinol Metab. 82. 2731-2737 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takano K, Teramoto A, et al.: "Gi3 mediates somatostatin-induced activation of an inwardly rectifying K+ current in human growth hormone-secreting adenoma cells" Endocrinology. 138. 2405-2409 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sanno N, Teramoto A, et al.: "Immunohistochemical expression of retinoid X receptor isoforms in human pituiaries and pituitary adenomas." Neuro-endocrinol. 65. 299-306 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sanno N, Teramoto A, et al.: "Clinical and cytofunctional classification of pituitary adenomas." Acta Neurochir(Wien). 138. 1186-1192 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sanno N, Teramoto A, et al.: "Immunohistochemical detection of human natural killer cell like immunoreactivity in human pituitary adenomas,using monoclonal antibody NK-1" J Neuro-oncol. 35. 29-38 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 寺本 明: "Cushing病の診断:最近の動向" Neurological Surgery. 25. 7-16 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 岩田 誠、寺本 明: "キーワードを読む 脳・神経" 医学書院(東京), 159 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sanno N,Teramoto A,Osamura RY :"Chnical and cytofunctional classification of pituitary adenomas." Acta Neurochir (Wien). 138. 1186-1192 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sanno N,Teramoto A,Matsuno A,Takekoshi S,Osamura RY :"Expression of Pit-1 product in human pituitary adenomas. Histochemical studies by antibody against synthetic human Pit-1." Archives of Pathology and Laboratory Medicine. 120. 73-77 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sanno N,Matsuno A,Itoh J,Teramoto A,Osamura RY :"Combined Non-isotopic in situ hybridization method and indirect immunohistochemical analysis of hormone production in rat pituitary." J Clin Pathol : Mol Pathol. 49. M57-M60 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sanno N,Teramoto A,Matsuno A,Takekoshi S,Osamura RY :"In situ hybridizaytion analysis of Pit-1 mRNA and hormonal production in human pituitary adenomas." Acta Neuropathol. 91. 263-268 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sanno N,Teramoto A,Matsuno A,Osamura RY :"Expression of Pit-1 and estrogen receptor messenger ribonucleic acids in prolactin producing pituitary adenomas : Non-radioisotopic in situ hybridization analysis." Modern Pathology. 9. 526-533 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sanno N,Teramoto A,Sugiyama M,Itoh Y,Osamura RY :"Application of CSA in immunodetection of gonadotropin subunits in clinically non-functioning pituitary adenomas." Am J Clin Pathol. 106. 16-21 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsuno A,Sasaki T,Mochizuki T,Fujimaki T,Sanno N,Osamura RY,Teramoto A,Kirino T :"A case of pituitary somatotroph adenoma with concomitant secretion of growth hormone, prolactin, and adrenocorticotropic hormone : An adenoma derived from primordial stem cell, studied by immunohistochemistry, in situ hybridization and cell culture." Acta Neurochir (Wien). 138. 1002-1007 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sano T,Seki Y,Umezu H,Aiba T,Teramoto A,Takemori S.: "Follow-up results of preserved hearing after radical removal of acoustic neuromas" Acoustic Neuroma and Skull Base Surgery, edited by JM Sterkers, et al. Kugler Publications (Amsterdam) :. 297-301 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sano T,Seki Y,Aiba T,Teramoto A,Takemori S.: "Recurrent acoustic neuromas-clinical and pathological characteristics-" Acoustic Neuroma and Skull Base Surgery, edited by JM Sterkers Kugler Publications (Amsterdam) :. 181-183 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takano K,Takano JY,Teramoto A,Fujita T.: "Corticotropin-releasing hormone excites adrenocorticotropin-secreting human pituitary adenoma cells by activating a nonselective cation current" Clin Invest. 98(9). J2033-2041 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takano K,Takei T,Teramoto A,Yamashita N.: "GHRH activates a nonselective cation current in human GH-secreting adenoma cells" Am J Phydiol. 270(Endocrinol.Metab.33). E1050-E1057 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sanno N,Itoh J,Teramoto A,Itoh Y,Hori S,Osamura RY :"Immunohistochemical detection of human natural killer cell like immunoreactivity in human pituitary adenomas, using monoclonal antibody NK-1" J Neuro-oncol. 35. 29-38 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sanno N,Teramoto A,Osamura RY,Genka S,Katakami H,Jin L,Lloyd RV,Kovacs K :"A growth hormone-releasing hormone-producing pancreatic islet cell tumor metastasized to the pituitary is associated with pituitary somatotroph hyperplasia and acromegaly" J Clin Endocrinol Metab. 82. 2731-2737 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takano K,Takano JY,Teramoto A,Fujita T.: "Gi3 mediates somatostatin-induced activation of an inwardly rectifying K+ current in human growth hormone-secreting adenoma cells." Endocrinol. 138. 2405-2409 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamada S,Yoshimoto K,Sano T,Takada K,Itakura M,Usui M,Teramoto A.: "Inactivation of the tumor suppressor gene on 11q13 in brothers with familial acrogigantism without multiple endocrine neoplasia type I" J Clin Endocrinol Metab. 82. 239-242 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sanno N,Sugawara A,Teramoto A,Abe Y,Yen PM,Chin WW,Osamura RY :"Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas." Neuro-endocrinol. 65. 299-306 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sanno N,Teramoto A,et al.: "A growth hormone- releasing hormone-producing pancreatic islet cell tumor metastasized to pituitary is associated with pituitary somatotroph hyperplasia and acromegaly" J Clin Endocrinol Metab. 82. 2731-2737 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takano K,Teramoto A,et al.: "Gi3 mediates somatostatin-induced activation of an inwardly rectifying K+ current in human growth hormone-secreting adenoma cells" Endocrinology. 138. 2405-2409 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sanno N,Teramoto A,et al.: "Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas." Neuro-endocrinol. 65. 299-306 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sanno N,Teramoto A,et al.: "Clinical and cytofunctional classification of pituitary adenomas." Acta Neurochir(Wien). 138. 1186-1192 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sanno N,Teramoto A,et al.: "Immunohistochemical detection of human natural killer cell like immunoreactivity in human pituitary adenomas,using monoclonal antibody NK-1" J Neuro-oncol. 35. 29-38 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 寺本 明: "Cushing病の診断:最近の動向" Neurological Surgery. 25. 7-16 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Teramoto A: "Recent management of pituitary adenomas." J Nippon Med Sch. 63(4). 255-258 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sanno N,Teramoto A,Sugiyama M,Osamura RY: "Application of catalyzed signal amplification in immunodetection of gonadotropin subunits in clinically nonfunctioning pituitary adenomas." Am J Clin Pathol. 106. 16-21 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sanno N,Teramoto A,Matsuno A,Itoh J,Takekoshi S Osamura RY: "In situ hybridization analysis of Pit-1 mRNA and hormonal production in human pituitary adenomas." Acta Neuropathol. 91. 263-268 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sanno N,Matsuno A,Itoh J,Kakimoto K,Teramoto A,Osamura RY: "Combined non-isotopic in situ hybridization and indirect immunohistochemical analysis of hormone production in the rat pituitary gland." J Clin Pathol ; Mol Pathol. 49. M57-M60 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sanno N,Teramoto A,Osamura RY: "Clinical and cytofunctional classification of pituitary adenomas." Acta Neurochir (Wien). 138. 1186-1192 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takano K,Takei T,Teramoto A,Yamashita N: "GHRH activates a nonselective action current in human GH-secreting adenoma cells." Am J Physiol. 270. E1050-E1027 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 寺本 明: "脳神経外科 戸谷重雄編 下垂体腺腫等" 南山堂, 22 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 寺本 明: "間脳下垂体腫瘍の臨床『現代の神経内分泌学』" メディカル・サイエンス・インターナショナル(東京), 8 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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