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Clinical Significance of Coagulation Disorder, Production of Freeradical, PGE_2 to prevent early delivery.

Research Project

Project/Area Number 08457433
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

SUZUKI Shigenori  College of Medical Technology, Hokkaido Univ., 医療技術短期大学部, 教授 (10001926)

Co-Investigator(Kenkyū-buntansha) SAKAMOTO Wataru  Fac.of Dent.Med., Hokkaido Univ., 歯学部, 助教授 (30001952)
MATSUNO Kazuhiko  College of Medical Technology, Hokkaido Univ., 医療技術短期大学部, 教授 (70102332)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1996: ¥4,900,000 (Direct Cost: ¥4,900,000)
KeywordsEarly Devliery / PAI-1 / PAI-2 / PFA-100 / PHC / ADP / Epinephrine / Euglobulin-Lysis-Time (ELT) / 陣痛 / 血小板 / プレカリクレイン / キニン系 / 分娩発来機構 / TAT / ブラジキニン / FDP / SFMC / キニノーゲン
Research Abstract

(Purpose)
Blood coagulationfactors, Fibrinolysis, Kinin-Kallikrein System, and PHG(Platelet hemostatic capacity)were measured in blood from early delivery and normal delivery during l-3 trimester.
Since fibrin plays an important role in maintaining the integrity of the uteroplacental circulation, it is very important to understand the role that the fibrinolytic inhibitors, PAl-land PAI-2 plays in the context.
Of equal importance is platelet function during pregnancy and onset of delivery. Platelet hemostatic capacity(PHC) was determined by a PFA-100, which is microprocessor-controlled instrument/test cartridge system that stimulates platelet-based primary hemostasis, thereby representing a new in vitro bleeding time test.
(Methods)
20 normal delivery and 17 early delivery were tested during 1st trimest-er, 2nd trimester, 3rd trimester and at the onset of labor. Additionally 16 none pregnant women were investigated as a control group. Markers of in vivo hemostatic activation , fibrinolytic parameters were measured as follows. : TAT, F_<1+2>, PAI-1, PAI-2, were analyzed using the following commercial kits : TAT(Thrombin-Antithrombin III Complex) (Dade-Behring, Marburg, Germany) F1+2(Dade-Behring, Marburg, Germany), PAI- 1(Plasminogen activator inhibitor 1) and PAI-2(Plasminogen activator inhibitor 2) (Biopool, Umea, Sweden)
(Results)
1) PFA-100 analysis was performed with collagen-epinephrine(PCE) and with collagen-APP cartridges. (PCA) during normal pregnancy, especially in second trimester, both PCE(98.0+2 1.0) and PCA(76.5 + 28.6) were shortened .as well as early delivery.
2) Plasminogen activator inhibitors PM-1 and PAI-2 were both increased during normal pregnancy , especially in the second trimester. There was no significant difference between normal pregnancy and early delivery.
3)At the onset of delivery, especially in the cases of early delivery, ELT (Euglobulin-Lysis-Time) was shortened (average 210 min, 3hours and 30 minutes).

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Suzuki S: "Hypercoagulability and DIC in high-risk Infants." Seminars in thrombosis and hemostasis. 24(5). 463-465 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki S: "Platelet hemostatic capacity(PHC)and fibrinolytic inhibitors during pregnancy." Seminars in thrombosis and hemostasis. 24(5). 449-451 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Yamada: "Passive Immune Thrombocytopenia in Pregnancy Complicated by Idiopathic Thrombocytopenic Purpura" Seminars in Thrombosis and Hemostasis. in Press. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 鈴木重統: "PFA-100による周産期母児血小板機能の解析" 日本産科婦人科新生児血液学会誌. 8(2). S27-S28 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki.S: "Hypercoagulability and DIC in high-risk Infants." Seminars in Thrombosis and Hemostasis. 24 (5). 463-465 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki S: "Platelet Hemostatic Capacity (PHC) and fibrinolytic inhibitors during pregnancy." Seminars in Thrombosis and Hemostasis. 24 (5). 449-451 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki S.: "Hypercoagulability and DIC in high-risk Infants." Seminars in thrombosis and hemostasis. 24(5). 463-465 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Suzuki S.: "Platelet hemostatic capacity(PHC) and fibrinolytic inhibitors during pregnancy." Seminars in thrombosis and hemostasis. 24(5). 449-451 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Yamada: "Passive Immune Thrombocytopenia in Pregnancy Complicated by Idiopathic Thrombocytopenic Purpura" Seminars in Thrombosis and Hemostasis. (in Press) (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 鈴木重統: "PFA-100による周産期母児血小板機能の解析" 日本産科婦人科新生児血液学会誌. 8(2). S27-S28 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shigenori Suzuki: "Hypercoagulable state and DIC in high-risk infants" Annals of Hematology. supplement vol 76. 84- (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shigenori Suzuki: "In vitro Bleeding-Time during Women′s Life Cycle" New Aspects of Perinatal Medicine and Peinatal Hemostasis. (印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 坂本亘, 鈴木重統: "マクロファージのPGE_2産生とその制御" フリーラジカルの臨床. 12. 53-57 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 鈴木重統: "血液疾患とその周辺" 新女性医学大系 第23巻. 第23巻. (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] W. Sakamoto et al S, Suzuki: "Degradation of T-Kininogen by cathepsin O and matrix metalloproteinase" Immunopharmacology.32. 73-75 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tandon. N. A. Matsuno. K et al: "Effect of non-clustered antiplatelet monoclonal antibodles on Collagen-induced Platelet aggregation and adherenceto immobilized type Icollagen fibrills." Leukocyte Typing V. 1218-1219 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shigenori Suzuki Kazuhiko Matsuno: "The in vitro Bleeding Time and Platelet-Aggregation Relevant to Women′s Lifecycle" New Aspect of Perinatal Thrombosis and Hemostasis.(in press). (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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