| Project/Area Number |
08457461
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Gifu University |
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Principal Investigator |
KITAZAWA Yoshiaki Gifu University, Ophthalmology, Professor, 医学部, 教授 (20009484)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASE Kazuhide Gifu University, Ophthalmology, Assistant Professor, 医学部・附属病院, 助手 (40234067)
TANIGUCHI Toru Gifu University, Ophthalmology, Assistant Professor, 医学部, 助手 (30179840)
SUGIYAMA Kazuhisa Gifu University, Ophthalmology, Assistant Professor, 医学部・附属病院, 講師 (80179168)
TOMITA Goji Gifu University, Ophthalmology, Assistant Professor, 医学部・附属病院, 講師 (30172191)
YAMAMOTO Tetsuya Gifu University, Ophthalmology, Associate Professor, 医学部, 助教授 (50134581)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥7,600,000 (Direct Cost: ¥7,600,000)
Fiscal Year 1998: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1997: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥3,700,000 (Direct Cost: ¥3,700,000)
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| Keywords | normal-tension glaucoma / confocal scanning ophthalmoscope / optic disc / parapapillary atrophy / retinal ganglion cell death / color doppler imaging / ocular blood flow / NMDA receptor antagonist / apoptosis / 共焦点レーザ眼底観察測定装置 / 二酸化炭素濃度 / カラードップラー / 自己免疫異常 |
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| Research Abstract |
1. The size of peripapillary atrophy (zone-beta induced by the circulatory disturbance in peripapillary choroid was found to be closely associated with the severity of glaucomatous optic nerve damage in normal-tension glaucoma (NTG). On the other hand any significant association was not noted in primary angle-closure glaucoma (PACG). The result suggests that the circulatory disturbance is involved with the pathogenesis of optic nerve damage in NTG and that the vascular factor does not play a significant role in the development of the optic nerve damage in PACG.
2. Retrobulbar blood flow parameters evaluated by Color-Doppler Imaging technique were noted to significantly improve following oral administration of nilvadipine, Ca^<2+>-blocker, in NTG patients, indicating a possible, concomitant, vasospastic event in NTG.
3. The expression of Bcl 2 and Bax protein in the eye of experimentally induced glaucoma monkeys and rats with was studied by means of RT-PCR and immuno-histochemistry. The expression of Bcl 2 was found to be decreased but that of Bax was uncharged indicating the apoptic cell death in the retinal tissue. in the same experimental glaucoma model the loss of retinal ganglion cells was significantly inhibited by intraperitoneally injected memantine, Ca^<2+>-blockers and tacrolimus, an immunosuppressive agent. The result indicates that the compounds deserve further investigation for their possible neuroprotective effects in glaucoma.
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