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Molecular Biology and Psychophysiology on The Cone Opsins of Color Vision Defects

Research Project

Project/Area Number 08457469
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionJIKEI UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

KITAHARA Kenji  JIKEI UNIVERSITY SCHOOL OF MEDICINE,DEPERTMENT OF OPHTHALMOLOGY,PROFESSOR, 医学部, 教授 (80056853)

Co-Investigator(Kenkyū-buntansha) YAMAGUCHI Tomohiko  JIKEI UNIVERSITY SCHOOL OF MEDICINE,DEPERTMENT OF OPHTHALMOLOGY,FACULTY OF MEDIC, 医学部, 講師 (70220267)
GUNJI Hisato  JIKEI UNIVERSITY SCHOOL OF MEDICINE,DEPERTMENT OF OPTHALMOLOGY,FACULTY OF MEDICI, 医学部, 講師 (50186574)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1996: ¥3,400,000 (Direct Cost: ¥3,400,000)
Keywordscongenital color vision defect / pigmentpharbenanomaly / female color vision defects / female carrier of color vision defects / 赤視物質遺伝子 / 緑視物質遺伝子 / 赤緑融合遺伝子 / 緑赤融合遺伝子
Research Abstract

Pigmentpharbenanomaly, a kind of the congenital red-green color blindness which indicates color muching by anomaloscope. We investigated the sequences of all exons of the red and green pigment genes of two pigmentpharbenanomalies. Because of the sequences were all-same as that of normal color vision, It was thought that the mechanism of Pigmentpharbenanomaly is not the abnormality of the opsins in cones.
We succeeded in the genetic analyze of male congenital color vision defects by quantitative PCRSSCP.But in female color vision defects, two X-chromosomes made the analyze is impossible.
In the analyze of the female carrier of color vision defect, we succeeded in the detection of the color vision defect gene in only protanomalous carrier but not in deuteranomalous carrier.
The mRNAs of opsin genes are in White Blood Cells (WBC) is well known. We tried to compare the mRNAs in WBC with the phenotype-color vision. Very little amount of mRNA in WBC made the analyze difficult.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 北原 健二: "色覚の分子生物学" 光学. 26・5. 240-245 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 北原 健二: "色覚と遺伝子" 視覚の科学. 18・4. 100-105 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 北原 健二: "先天色覚異常" 眼科. 40・10. 1403-1409 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 北原 健二: "色覚の個人差と分子生物学" 日本眼科学会雑誌. 102・12. 837-849 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] KITAHARA Kenji: "Molecular Biology in Color Vision (In Japanese)" KOUGAKU. 26 : 5. 240-245 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] KITAHARA Kenji: "Genetics in Color Vision (In Japanese)" SCIENCE IN VISION. 18 : 4. 100-105 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] KITAHARA Kenji: "Congenital Color Vision Defect (In Japanese)" GANKA. 40 : 10. 1403-1409 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] KITAHARA Kenji: "Personality in Color Vision (In Japanese)" Journal of Japanese Ophthalmological Society. 102 : 12. 837-849 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 北原 健二: "色覚の分子生物学" 光学. 26・5. 240-245 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 北原 健二: "色覚と遺伝子" 視覚の科学. 18・4. 100-105 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 北原 健二: "先天色覚異常" 眼科. 40・10. 1403-1409 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 北原 健二: "色覚の個人差と分子生物学" 日本眼科学会雑誌. 102・12. 837-849 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 北原健二: "色覚異常" 小児科診療. 12. 2001-2007 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 北原健二: "色覚の分子生物学" 光学. 26・5. 240-245 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 山口 朋彦: "Levels of expression of the red,green and green-red hybrid pigment genes in the human retina" Color Vision Deficiencies. 8. 21-31 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 山口 朋彦: "Visual pigment gene structure and expression in human retinae" Human Molecular Genetics. 6・7. 981-990 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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