| Project/Area Number |
08457495
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
ICHIJO Hidenori Japanese Foundation for Cancer Research The Cancer Institute, Dept.Biochemistry, Principal Investigator, 癌研究所生化学部, 主任研究員 (00242206)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Kohsuke Japanese Foundation for Cancer Research The Cancer Institute, Dept.Biochemistry,, 癌研究所生化学部, 研究員
MIYAZONO Kohei Japanese Foundation for Cancer Research The Cancer Institute, Dept.Biochemistry,, 癌研究所生化学部, 部長 (90209908)
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| Project Period (FY) |
1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1996: ¥6,300,000 (Direct Cost: ¥6,300,000)
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| Keywords | TGF-beta / TGF-beta superfamily / GDF / BMP / Receptor serine / threonine kinase / シグナル伝達 / アポトーシス |
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| Research Abstract |
The members in the TGF-beta superfamily appear to have essential roles in development and cancer. The relationship between the TGF-beta superfamily ligands and their receptors is not well understood in the context of their specificity and affinity. In order to analyze the ligand-receptor relationship as well as signal transduction mechanism, we performed following studies. 1) The receptors for GDF-5 was identified by affinity cross-linking using iodinated GDF-5.2) The signals for growth inhibition and matrix induction by TGF-beta was found to be separated by introducing mutations into TGF-beta type I receptor. 3) A new gene termed BMP/OP-responsive gene (BORG) was isolated by a differential dis, play method. 4) A novel MAPKKK,ASKI was isolated and found to be a key component of the signal transduction of apoptosis.
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