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STUDY FOR INTRACELLULAR SIGNAL TRANSDUCTION MECHANISM OF TGF-beta SUPERFAMILY.

Research Project

Project/Area Number 08457495
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

ICHIJO Hidenori  Japanese Foundation for Cancer Research The Cancer Institute, Dept.Biochemistry, Principal Investigator, 癌研究所生化学部, 主任研究員 (00242206)

Co-Investigator(Kenkyū-buntansha) TAKEDA Kohsuke  Japanese Foundation for Cancer Research The Cancer Institute, Dept.Biochemistry,, 癌研究所生化学部, 研究員
MIYAZONO Kohei  Japanese Foundation for Cancer Research The Cancer Institute, Dept.Biochemistry,, 癌研究所生化学部, 部長 (90209908)
Project Period (FY) 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1996: ¥6,300,000 (Direct Cost: ¥6,300,000)
KeywordsTGF-beta / TGF-beta superfamily / GDF / BMP / Receptor serine / threonine kinase / シグナル伝達 / アポトーシス
Research Abstract

The members in the TGF-beta superfamily appear to have essential roles in development and cancer. The relationship between the TGF-beta superfamily ligands and their receptors is not well understood in the context of their specificity and affinity. In order to analyze the ligand-receptor relationship as well as signal transduction mechanism, we performed following studies. 1) The receptors for GDF-5 was identified by affinity cross-linking using iodinated GDF-5.2) The signals for growth inhibition and matrix induction by TGF-beta was found to be separated by introducing mutations into TGF-beta type I receptor. 3) A new gene termed BMP/OP-responsive gene (BORG) was isolated by a differential dis, play method. 4) A novel MAPKKK,ASKI was isolated and found to be a key component of the signal transduction of apoptosis.

Report

(2 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Saitoh,M.: "Identification of important regions in the cytoplasmic domain of type I receptor that separate signaling pathways of transforming growth factor-β." J.Biol.Chem.271. 2769-2775 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nishitoh,H.: "Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5." J.Biol.Chem.271. 21345-21352 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Harumiya,S.: "Charactrization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1." J.Biochem.120. 745-751 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Okadome,T.: "Characterization of the interaction of FKBP12 with the transforming growth factopr-β type I receptor in vivo." J.Biol.Chem.271. 21687-21690 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ichijo,H.: "Induction of apoptosis by ASK1,a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways." Science. 275. 90-94 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Olofsson,A.: "A latent transforming growth factor-β complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor,also termed E-selectin-ligand or MG-160." Biochemical Journal. 324. 427-434 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Saitoh, M., Nishitoh, H., Amagasa, T., Miyazono, K., Takagi, M.and Ichijo, H.: "Identification of important regions in the cytoplasmic domain of type I receptor that separate signaling pathways of transforming growth factor-beta." J.Biol.Chem.271. 2769-2775 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nishitoh, H., Ichijo, H., Kimura, M., Matsumoto, T., Makishima, F., Yamaguchi, A., Yamashita, H., Enomoto, S.and Miyazono, K.: "Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5." J.Biol.Chem.271. 21345-21352 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Harumiya, S., Takeda, K., Sugiura, T., Fukumoto, Y., Tachikawa, H., Miyazono, K., Fujimoto, D.and Ichijo, H.: "Charactrization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1." J.Biochem.120. 745-751 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Okadome, T., Oeda, E., Saitoh, M., Ichijo, H., Moses, H.L.Miyazono, K.and Kawabata, M.: "Characterization of the interaction of FKBP12 with the transforming growth factopr-beta type I receptor in vivo." J.Biol.Chem.271. 21687-21690 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ichijo, H., Nishida, E., Irie, K., ten Dijke, P., Saitoh, M., Moriguchi, T., Takagi, M., Matsumoto, K., Miyazono, K.and Gotoh.: "Y.Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways" Science. 275. 90-94 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Olofsson, A., Hellman, U., ten Dijke, P., Grimsby, S., Ichijo, H., Moren, A.Miyazono, K.and Heldin, C-H.: "A latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160." Biochemical Journal. 324. 427-434 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Saitoh,M: "Identification of important regions in the cytoplusmic domain of type I receptor that separate signaling pathways of transforming growth factor-β." J.Biological Chemistry. 271. 2769-2775 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nishitoh,H: "Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5." J.Biological Chemistry. 271. 21345-21352 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ichijo,H: "Induction of apoptosis by ASKI,a mammalian MAPKKK that activates SAPK/JNK and P38 signaling pathways." Science. 275. 90-94 (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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