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Effect of irradiation on intramembranous ossification

Research Project

Project/Area Number 08457497
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 病態科学系歯学(含放射線系歯学)
Research InstitutionOsaka University

Principal Investigator

FUCHIHATA Hajime  Osaka University, Faculty of Dentistry, Professor, 歯学部, 教授 (70028728)

Co-Investigator(Kenkyū-buntansha) HIRANUMA Hiroko  Osaka University, Faculty of Dentistry, Clinical Staff, 歯学部・附属病院, 医員
FURUKAWA Souhei  Osaka University, Faculty of Dentistry, Assistant Professor, 歯医学部, 講師 (80173524)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥7,700,000 (Direct Cost: ¥7,700,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1996: ¥6,700,000 (Direct Cost: ¥6,700,000)
KeywordsRadiation / Osteoblast / differentiation / 膜性骨化
Research Abstract

Proliferation and changes in the phenotypic expressions of osteoblasts after X-irradiation were investigated. Osteoblast-like cells, MC3T3-E1, at actively proliferating, confluent, and post-proliferation stages were subjected to 10Gy-X-irradiation. One to 10Gy dose of Irradiation decreased the DNA content of cells. On the other hand, irradiation enhanced type I collagen accumulation and Ca content normalized to DNA contents. The expression of osteocalcin mRNA was downregulated by irradiation at all stages, but that of osteopontin and osteonectin mRNAs was unchanged. The time-dependent increase in alkaline phophatase activity per cell exceeded that of the control after irradiation at later stages. The localization of alkaline phophatase positive cells was concordant with that of calcification. In addition, the quality of the calcium deposits was found to be similar to the control by energy dispersive spectrometry and calcium to phosphorus ratio determination, even if they were not exactly the same morphologically. taken together, changes in phenotypic expressions were closely related to calcification enhancement.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] H.Fuchihata: "Effect of X-ray irradiation on proliferation and differentiation of osteoblast" Calcified Tissue International. 59. 307-308 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Fuchihata: "Effects of X-ray irradiation on the proliferation and differentiation of osteoblasts" IADMFR/CMI'97-Advances in Maxillofacial Imaging. 423-426 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Hiranuma: "Changes in Phenotypic expressions of osteoblasts after X-irradiation" Radiation Research. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Fuchihata: "Effect of X-ray irradiation on proliferation and differentiation of osteoblast" Calcified Tissue International. 59. 307-308 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Fuchihata: "Effects of x-ray irradiation on the proliferation and differentiation of osteoblasts" IADMFR/CMI'97-Advances in Maxillofacial Imaging. 423-426 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Hiranuma: "Changes in phenotypic expressions of osteoblasts after X-irradiation" Radiation Research. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Fuchihata: "Effect of X-ray irradiation on proliferation and differentiation of osteoblast" Calcified Tissue International. 59. 307-308 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Fuchihata: "Effects of X-ray irradiation on the proliferation and differentiation of osteoblasts" IADMFR/CMI'97-Advances in Maxillofacial Imaging. 423-426 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Hiranuma: "Changes in phenotypic expressions of osteoblasts after X-irradiation" Radiation Research. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Fuchihata: "Effect of X-ray irradiation on proliferation and differentiation of osteoblast" Calcified Tissue International. 59. 307-308 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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