| Project/Area Number |
08457509
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
KATO Ihachi Nagasaki University, School of Dentistry, Professor, 歯学部, 教授 (30005087)
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| Co-Investigator(Kenkyū-buntansha) |
TANI Masahiko Nagasaki University, Hospital Attached to School of Dentistry, Assistant Profess, 歯学部・附属病院, 講師 (70188374)
IKEDA Yasuo Nagasaki University, School of Dentistry, Instructor, 歯学部, 助手 (90274670)
UKAI Takashi Nagasaki University, School of Dentistry, Instructor, 歯学部, 助手 (20295091)
ABE Yoshihiro Nagasaki University, School of Dentistry, Instructor, 歯学部, 助手 (70202687)
HARA Yoshitaka Nagasaki University, School of Dentistry, Associate Professor, 歯学部, 助教授 (60159100)
吉村 篤利 長崎大学, 歯学部, 助手 (70253680)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 1997: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1996: ¥5,800,000 (Direct Cost: ¥5,800,000)
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| Keywords | Periodontopathic bacteria / Lipopolysaccharide / Periodontal tissue / Periodontal pocket / Histopathological study / Actinobacillus actinomycetemcomitans / Porphyromonas gingivalis / 内毒素 / 接合上皮 |
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| Research Abstract |
Lipopolysaccharide from Actinobaci11us actinomycetemcomitans (A.a) Y4 and Porphyromonas gingivalis (P.g) 381 was dropped into the gingival sulcus of rat. The mandibles were examined histopathologically. Inflammatory findings gradually increased in both LPS groups. However, A.a LPS induced stronger inflammation and degeneration of periodontal tissue. Loss of connective tissue attachment and elongation of rete peg were significantly higher in rats administrated with A.a LPS compared to those administrated with P.g LPS.These findings suggest a stronger effect of A.a LPS on periodontal tissue destruction.
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