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Immunohistological study on infiltration of periodontopathic bacterial lipopolysaccharide into gingiva and lesional lymph node.

Research Project

Project/Area Number 08457509
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionNagasaki University

Principal Investigator

KATO Ihachi  Nagasaki University, School of Dentistry, Professor, 歯学部, 教授 (30005087)

Co-Investigator(Kenkyū-buntansha) TANI Masahiko  Nagasaki University, Hospital Attached to School of Dentistry, Assistant Profess, 歯学部・附属病院, 講師 (70188374)
IKEDA Yasuo  Nagasaki University, School of Dentistry, Instructor, 歯学部, 助手 (90274670)
UKAI Takashi  Nagasaki University, School of Dentistry, Instructor, 歯学部, 助手 (20295091)
ABE Yoshihiro  Nagasaki University, School of Dentistry, Instructor, 歯学部, 助手 (70202687)
HARA Yoshitaka  Nagasaki University, School of Dentistry, Associate Professor, 歯学部, 助教授 (60159100)
吉村 篤利  長崎大学, 歯学部, 助手 (70253680)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 1997: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1996: ¥5,800,000 (Direct Cost: ¥5,800,000)
KeywordsPeriodontopathic bacteria / Lipopolysaccharide / Periodontal tissue / Periodontal pocket / Histopathological study / Actinobacillus actinomycetemcomitans / Porphyromonas gingivalis / 内毒素 / 接合上皮
Research Abstract

Lipopolysaccharide from Actinobaci11us actinomycetemcomitans (A.a) Y4 and Porphyromonas gingivalis (P.g) 381 was dropped into the gingival sulcus of rat. The mandibles were examined histopathologically. Inflammatory findings gradually increased in both LPS groups. However, A.a LPS induced stronger inflammation and degeneration of periodontal tissue. Loss of connective tissue attachment and elongation of rete peg were significantly higher in rats administrated with A.a LPS compared to those administrated with P.g LPS.These findings suggest a stronger effect of A.a LPS on periodontal tissue destruction.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 池田 康男 ほか: "歯周病原性細菌由来LPS歯肉溝滴下によるラット歯周組織の病理組織学的変化1.LPS1回滴下後の接合上皮における経時的組織変化" 日本歯科保存学会雑誌. 39巻 秋季特別号. 49 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 岩本 雅章 ほか: "歯周病原性細菌由来LPS歯肉溝滴下によるラット歯周組織の病理組織学的変化2.LPS頻回滴下後の接合上皮及び結合組織における変化" 日本歯科保存学会雑誌. 39巻秋季特別号. 50 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yasuo IKeda, et al.: "Destruction of rat periodontal tissue by the penetration of periodontopathic bacterial lipopolysaccharide through gingival sulcus." The 6th Meeting of International Academy of Periodontology. (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ikeda Y., Iwamoto M., Kaneko T., Hara Y., Kato I.: "Histopathological changes in periodontal tissue of rat induced by LPS from periodontopathic bacteria immersed into the gingival sulcus 1.Histopathological changes of junctional epithelium an immersion of LPS" The Japanese Journal of Conservative Dentistry. 39 (Autumn issue). 49 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iwamoto M., Ikeda Y., Kaneko T., Hara Y., Kato I.: "Histopathological changes in periodontal tissue of rat induced by LPS from periodontopathic bacteria immersed into the gingival sulcus 2.Changes of junctional epithelium and connective tissue after repeated immersion of LPS" The Japanese Journal of Conservative Dentistry. 39 (Autumn issue). 50 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ikeda Y., Iwamoto M., Kaneko T., Yoshimura A., Hara Y.and Kato I.: "Destruction of rat periodontal tissue by the penetration of periodontopathic bacterial lipopolysaccharide through gingival sulcus" The 6th Meeting of International Academy of Periodontology. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 池田 康男 ほか: "歯周病原性細菌由来LPS歯肉溝滴下によるラット歯周組織の病理組織学的変化 1.LPS 1回滴下後の接合上皮における経時的組織変化" 日本歯科保存学会雑誌. 39巻 秋季特別号. 49 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 岩本 雅章 ほか: "歯周病原性細菌由来LPS歯肉溝滴下によるラット歯周組織の病理組織学的変化 2.LSP頻回滴下後の接合上皮及び結合組織における変化" 日本歯科保存学会雑誌. 39巻 秋季特別号. 50 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yasuo Ikeda,et al.: "Destruction of rat periodontal tissue by the penetration of periodontopathic bacterial lipopolysaccharide through gingivial sulcus." The 6th Meeting of International Academy of Periodontology. (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 池田 康男 ほか: "歯周病原性細菌由来LPS歯肉溝滴下によるラット歯周組織の病理組織学的変化 1.LPS1回滴下後の接合上皮における経時的組織変化" 日本歯科保存学会雑誌. 39巻秋季特別号. 49- (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 岩本 雅章 ほか: "歯周病原性細菌由来LPS歯肉溝滴下によるラット歯周組織の病理組織学的変化 2.LPS頻回滴下後の接合上皮及び結合組織における変化" 日本歯科保存学会雑誌. 39巻秋季特別号. 50- (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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