| Project/Area Number |
08457519
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OHYAMA Takashi Tokyo Medical and Dental University, Faculty of Dentistry, Professor, 歯学部, 教授 (50064366)
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| Co-Investigator(Kenkyū-buntansha) |
MUKOHYAMA Hitoshi Tokyo Medical and Dental University, Faculty of Dentistry, Reseach Associate, 歯学部, 助手 (00242214)
KASUGAI Shohei Tokyo Medical and Dental University, Faculty of Dentistry, Associate Professor, 歯学部, 助教授 (70161049)
OHYA Keiichi Tokyo Medical and Dental University, Faculty of Dentistry, Professor, 歯学部, 教授 (10126211)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 1997: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1996: ¥6,400,000 (Direct Cost: ¥6,400,000)
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| Keywords | aging / tpptj extraction / bone mineral density / mandible / maxilla / osteoporosis / エストロゲン欠乏 / ラット / 下顎骨 / DEXA |
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| Research Abstract |
Bone mass is a key factor for success of various dental and oral treatment, and we consider about bone loss when applying dentures and dental implants to alveolar ridge. Despite the high risk for osteoporotic bone loss among the post menopausal elderly, effect of estrogen depletion on oral bones has been ambiguous. To determine if estrogen depletion and tooth extraction affects mandibular bone volume, we conducted the following experiments, using ovariectomized (OVX) rats. The first right molars of OVX and sham operated rats were extracted. 109 days postovariectomy, the rats were sacrificed and measured the bone mineral density of right mandibles with dual energy X-ray absorptiometry (DEXA) and peripheral Quantitative Computed Tomography (pQCT). Significant difference between OVX rats and sham rats was not detected when whole mandible bodies were scanned by DEXA.However, there was significant difference when the condyle was scanned. Further, trabecular bone mineral density and cortical bone mineral density around molars in the mandibles were separately measured with pQCT.In a limited area around the molars, trabecular bone mineral density was significantly decreased in the OVX group although cortical bone mineral density was not significantly different. By contrast, the maxillary molar extraction led to decrease in BMD though dit was not significant. In this study, the BMD of he condyle which is abound with trabecular bone and trabecular bone mineral density around molars were decreased in OVX rats. These results suggest that estrogen depletion mainly affects the trabecular bone in mandible. It will be necessary to conduct further experiments to clarify the effect of tooth extraction. Furthermore, we established a primary culture system dirived from rat bone marrow cells and have investigated anabolic or catabolic factor for bone.
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