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Basic Research for Prevention of Myocardial Infarction during Dental Treatment

Research Project

Project/Area Number 08457542
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTOKYO MEDICAL AND DENTAL UNIVERSITY

Principal Investigator

ITO Hiromichi  TOKYO MEDICAL AND DENTAL UNIVERSITY,Faculty of Dentistry, Dental Anesthesiology, Lecturer, 歯学部, 講師 (40110720)

Project Period (FY) 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1996: ¥6,600,000 (Direct Cost: ¥6,600,000)
KeywordsATP / adenosine / colored microspheres / myocardial infarction / dental treatment / nitric oxide concentration
Research Abstract

In the advent of the society of aged people, the most aged dental patients have many complications. The serious diseases among them are a silent angina pectoris and a myocardial infarction. It is nessesary to prevent the incidence of such a cardiogenic shock during dental procedures.
ATP as a potent vasodilator both in animals and human beings has been used for hypotensive anesthesia by us. So we expect that the administration of ATP to the patients with the myocardial infraction or the silent angina pectoris will be useful to prevent the heart attack during dental treatments.
The aim of this basic research is to detect the coronary vasodilative effects of ATP on the opened beating heart in rabbit.
The regional blood flow (RBF) was measured in the heart by the colored microspheres method. The myocardial tissue oxygen tension (Pt02) and nitric oxygen tension (CtNO) were also determined in the left ventricular myocardium by the polarography method to evaluate the effect of ATP.
ATP or glycerin trinitrate (TNG) was administrated after 15 minutes' ligation of left descending coronary artery. The administration of ATP more increased both RBF amd Pt02 than the administration of TNG.Also ATP controlled minimum release of CtNO from the left ventricular myocardium.
These results suggest that a coronary stenosis and infarction in a case of the acute myocardial attack might be effectively reperfused by ATP.We would like to try further investigations so as to use ATP to dental patients.

Report

(2 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 加藤 誠一: "ATP低血圧麻酔時の臓器局所血液量ならびに心筋PO_2およびNO濃度について-ウサギでのカラードマイクロリフェア法による局所血流量測定-" 日本歯科麻酔学会雑誌. 25. 184-196 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kato S: "The alterations of organ regional blood flow (RBF), tissue oxygen tension (PtO_2) and nitric oxide concentration (CtNO) during ATP-induced hypotensive anesthesia -Measurement of the RBC by colored microspheres method in rabbits-" Journal of Japanese Dental Society by Anesthesiology. 25. 184-196 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 加藤誠一: "ATP低血圧麻酔時の臓器局所血流量ならびに心筋PO_2およびNO濃度について-ウサギでのカラードマイクロソフェア法による局所血流量測定-" 日本歯科麻酔学会雑誌. 25巻・2号. 184-196 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 伊藤弘通: "歯科治療時の心筋梗塞発症の予防に関する基礎的研究" 日本歯科麻酔学会雑誌. (発表予定). (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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