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STUDY ON CHARACTERISTICS OF TUMOR CELLS AND MICRO ENVIROMENTAL FACTORS OF HIGHLY INVASIVE ORAL SQUAMOUS CELL CARCINOMA

Research Project

Project/Area Number 08457553
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionSAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

NOGUCHI Makoto  SAPPORO MEDICAL UNIVERSITY,SCHOOL OF MEDICINE,DEPT.OF ORAL SURGERY,ASSISTANT PROFESS, 医学部, 講師 (50208328)

Co-Investigator(Kenkyū-buntansha) IDE Takeshi  SAPPORO MEDICAL UNIVERSITY,SCHOOL OF MEDICINE,DEPT.OF ORAL SURGERY,INSTRUCTOR, 医学部, 助手 (70274933)
関口 隆  札幌医科大学, 医学部, 講師 (00240929)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1996: ¥4,900,000 (Direct Cost: ¥4,900,000)
KeywordsORAL CANCER / CELLULAR DNA CONTENTS / TYPE I COLLAGEN / VEGF / GLUT-1 / 舌扁平上皮癌由来細胞株 / Glucose transpoter-1 / VEGF isotype / 内皮細胞 / 細胞間透過性 / 口腔扁平上皮癌 / 癌浸潤様式 / 核DNA量 / 7型コラーゲン / 血管新生因子 / 超4C率 / FactorVIII / CD34
Research Abstract

1. Cellular DNA Contents
(1) Cytometric analysis was useful in detecting DNA aneuploid cells, especially when small numbers of cancer cells intermingled with stromal cells.
(2) Prognostic value of malignancy grading based on mode of cancer invasion and rate of cells exceeding 4C DNA contents (4CER) was suggested.
2. Interstitial Collagen Deposition
(1) Immunohistochemical localization of type VII collagen at the invading edge of tumors may reflect the histological malignancy of oral squaous cell carcinoma(oral SCC).
(2) Immunostaining pattern for type I collagen of oral SCC can provide information of importance in determining safe margins.
3. Influence to Barrier Function of HUVEC HUVEC added conditioning medium of more invasive oral SCC cell line showed higher transcellular electrical resistance than other oral SCC cell line with lower invasive potential.
4. Expression of VEGF/VPF and GLUT-1
(1) Expression of GLUT-1 was not found in OSC 30. In OSC 70, GLUT-1 expressed intensively in their cytoplasm.
(2) Although the expression of VEGF were detected in both cell lines, the staining patters were different between OSC3O and OSC7O.
(3) VEGF isotypes was similar between both cell lines.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Takashi Sekiguchi: "Clinical Significance of intertitial collagen deposition at invading edge in oral Cancer" Internatinal Journal of Clinical Oncology. 2. 21-28 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 野口 誠: "口腔扇平上皮癌の癌浸潤様式と核DNA量に基づく悪性度診断と治療へのフィードバック" 頭頸部腫瘍. 23・3. 691-697 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 仲盛健治: "口腔扁平上皮癌における細胞核DNA量解析" 日口外誌. 44. 617-624 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 関口 隆: "口腔扁平上皮癌の発育先進部におけるVII型コラーゲンの局在" 日口外誌. 42. 147-154 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TAKASHI SEKIGUCHI st al.: "Clinical significance of interstitial collagen deposition at the invading edge in oral cancer : immunohistochemistry for Type I collagen." Int.J.Clin.Onc.Vol.2. 21-28 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] MAKOTO NOGUCHI et al.: "Malignancy grading based on mode of invasion and nuclear DNA contents for oral squamous cell carcinomas" Head and Neck Cancer. 23 (3). 691-697 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 野口 誠: "口腔扁平上皮癌の癌浸潤様式と核DNA量に基づく悪性度診断と治療へのフィードバック" 頭頸部腫瘍. 23・3. 176-182 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 野口 誠: "高度浸潤性口腔癌の臨床病態像" 日本口腔科学会雑誌. 45・2. 184-189 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 野口 誠: "高度浸潤性口腔癌の治療に関する検討-Stage I,II舌癌について-" 日本口腔腫瘍学会誌. 8・1. 1-7 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 野口 誠: "口腔粘膜癌におけるNl-3症例の予後因子" 頭頸部腫瘍. 22・1. 168-172 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 関口 隆: "口腔扁平上皮癌の発育先進部におけるVII型コラーゲンの局在" 日本口腔外科学会雑誌. 42・2. 147-154 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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