| Project/Area Number |
08457580
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHIBASAKI Masakatsu The University of Tokyo The Graduate School of Pharmaceutical Sciences, Professor, 大学院薬学系研究科, 教授 (30112767)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Takayoshi The University of Tokyo The Graduate School of Pharmaceutical Sciences, Research, 大学院薬学系研究科, 助手 (80272483)
SASAI Hiroaki The University of Tokyo The Graduate School of Pharmaceutical Sciences, Associat, 大学院薬学系研究科, 助教授 (90205831)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥7,600,000 (Direct Cost: ¥7,600,000)
Fiscal Year 1997: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1996: ¥3,900,000 (Direct Cost: ¥3,900,000)
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| Keywords | Aldol / Asymmetric Catalyst / Palladium / エノールシリルエーテル / パラジウム / エノールシ / 触媒的不斉合成 / シリルエノールエーテル / BINAP |
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| Research Abstract |
Developing a catalytic asymmetric aldol reaction is a formidal challenge nowadays. Chiral Lewis acid catalysts have been reported. However, this approach still has many problems in versatility and applicability. Thus, we investigated novel approach by using the chiral palladium catalyst. We have found that the aldol reaction proceeds in high yield and ee via the palladium enolate even in the presence of small amount of water. Furthermore, we have investigated and determined the catalyst structure and the reaction mechanism.
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