| Project/Area Number |
08457589
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Fukuyama University |
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Principal Investigator |
SHIBUYA Hirotaka Fukuyama University, Pharm. &Pharm. Sci, Professor, 薬学部, 教授 (50116042)
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| Co-Investigator(Kenkyū-buntansha) |
OHASHI Kazuyoshi Fukuyama University, Pharm. &Pharm. Sci, Lecturer, 薬学部, 講師 (90213826)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥5,900,000 (Direct Cost: ¥5,900,000)
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| Keywords | tropical medicinal plant / malaria / chloroquine-resistant / Plasmodium faciparum / inhibitory activity against proliferation / Indonesia / マラリア原虫 |
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| Research Abstract |
This research project used Indonesian medicinal plants which has been used as folk medicines in the country, and aimed at finding ant-malarial substances from them.
As the result, we found interesting findings as following. 1)It had been found that a new clerodane-type diterpene named peronemin A2 isolated from the leaves of Peronema canescens (Verbenaceae) exhibits anti-malarial activity in vitro. 2)A new acid-amide named hazaleamide isolated from the bark of Fagara rhetza (Rutaceae) and a benzylisoquinoline alkaloid named dehatrine isolated from the wood of Beilschmiedia madang (Lauraceae) exhibit the same activity.
Furthermore, the preliminary screening for forty kinds of Indonesian medicinal plants revealed the water decoction of the root of Eurycoma longifolia (Simaroubaceae) shows strongly the antimalarial activity against the pathogen Plasmodium falciparum.
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