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Evaluation of the metabolisms of calcium and magnesium in the cardiovascular diseases

Research Project

Project/Area Number 08457639
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

OSHIMA Tetsuya  Hiroshima University School of Medicine, Associate Professor, 医学部, 助教授 (40233100)

Co-Investigator(Kenkyū-buntansha) MATSUURA Hideo  Hiroshima University Medical Hostpital, Assistant Professor, 医学部・附属病院, 講師 (50136040)
KAMBE Masayuki  Hiroshima University of School of Medicine, Professor, 医学部, 教授 (70034139)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥7,600,000 (Direct Cost: ¥7,600,000)
Fiscal Year 1997: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1996: ¥4,200,000 (Direct Cost: ¥4,200,000)
KeywordsCalcium / Magnesium / Hypertension / Angina Pectoris / Arrythmia / Diabetes Mellitus / Platelets / Erythrocytes / 高脂血症 / 尿中排泄量
Research Abstract

1. Although the deficiency of Ca or Mg has been suggeested to be associated with the cardiovascular diseases, the appropriate evaluation of the metabolism of these cations is not established. In the present study, we determined whether there is an abnormality in the systemic or cellular metabolism of Ca orMg in several cardiovascular diseases.
2. In patients with arrythmia, serum ionized Mg^<2+> concentration was reduced, whereas serum concentrations of total Ca and total Mg, and erythrocyte Mg concentration were normal.
3. In patients with coronary artery diseases, such as myocardial infarction, effort angina and vasospastic angina, serum concentrations of Ca^<2+> and Mg^<2+>, and erythrocyte Mg concentration were normal.
4. In patients with essential hypyertension, while serum concentrations of Ca^<2+> and Mg^<2+> were normal, [Mg^<2+>] i in platelets and erythrocytes, and Mg retention were increased.
5. In patients with diabetes mellitus, serum ionized Mg^<2+> concentration was decreased, while serum concentrations of Ca^<2+> and total Mg and erythrocyte Mg were normal.
6. All the indices were normal in patients with hyperlipidemia.
7. Although serum concentration of total Ca and total Mg were normal in the cardiovascular diseases, serum ionized Mg^<2+> was reduced in diabetes mellitus and arrythmia, and intracellular Mg concentration was increased in essential hypertension.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] Hiroyuki Hiraga: "Angiotensin I-converting enzyme gene polymorphism and salt sensitivity in essential hypertension" Hypertension. 27. 569-572 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yukihito Higashi: "Renal response to 1-arginine in salt sensitive patients with essential hypertension" Hypertension. 27. 643-648 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Norihisa Ono: "Platelet Ca^<2+> is not increased in stroke prone spontaneously hypertensive rats" Hypertension. 27. 1312-1317 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mari Ishida: "Effects of insulin on calcium metabolism and platelet aggregation" Hypertension. 28. 209-212 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mitsuisa Yoshimura: "Potentiotion of the intracellular Ca^<2+> response to arginine vasopressin by increased cytosolic free Mg^<2+>" Biochemica et Biophysica Acta. 1312. 151-157 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ryoji Ozono: "Modulation of traget tissue response to angiotensin II and sodium sensitivity in Japanese patients with essential hypertension" Hypertension Research. 19. 141-145 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mitsuisa Yoshimura: "Extracellular Mg^<2+> inhibits capacitive Ca^<2+> entry in vascular smooth muscle cells" Circulation. 95. 2567-2572 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yukihito Higashi: "Relationship between insulin resistance and endothelium-dependent vascular relaxation in patients with essential hypertension" Hypertension. 29. 280-285 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yukihito Higashi: "Nocturnal decline in blood pressure is attenuated by NaCl loading in salt-sensitive patients with essential hypertension" Hypertension. 30. 163-167 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yukihito Higashi: "Aging and severity of hypertension attenuate endothlium-dependent renal vascular relaxation in humans" Hypertension. 30. 252-258 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mitsuisa Yoshimura: "Differential effects of extracellular Mg^<2+> on thrombin-induced and capacitative Ca^<2+> entry in human coronary arterial endothelial cells" Arteriosclerosis,Thrombosis,and Vascular Biology. 17. 3356-3361 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ryoji Ozono: "Change in blood pressure during altered sodium intake in not associated with calciotropic hormone level" Clinical Science. 93. 153-157 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yukiko Nakano: "Angiotensin I-converting enzyme gene polymorphism and acutu response to captopril in essential hypertension" American Journal of Hypertension. 10. 1064-1068 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nobuo Sasaki: "Lack of effect of transmenmbrane gradient of magnesium and sodium on regulation of cytosolic free magnesium concentration in rat lymphocytes" Biochimica et Biophysica Acta. 1329. 493-498 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hiroyuki Hiraga: "Angiotensin I-converting enzyme gene polymorphism and salt sensitivity in essential hypertension" Hypertension. 27. 569-572 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yukihito Higashi: "Renal response to l-arginine in salt sensitive patients with essential hypertension" Hypertension. 27. 643-648 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Norihisa Ono: "Platelet Ca^<2+> is not increased in stroke prone spontaneously hypertensive rats" Hypertension. 27. 1312-1317 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mari Ishida: "Effects of insulin on calcium metabolism and platelet aggregation" Hypertension. 28. 209-212 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mitsuisa Yoshimura: "Potentiotion of the intracellular Ca^<2+> response to arginine vasopressin by increased cytosolic free Mg^<2+>" Biochemica et Biophysica Acta. 1312. 151-157 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ryoji Ozono: "Modulation of target tissue response to angiotensin II and sodium sensitivity in Japanese patients with essential hypertension" Hypertension Research. 19. 141-45 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mitsuisa Yoshimura: "Extracellular Mg^<2+> inhibits capactive Ca^+ entry in vascular smooth muscle cells" Circulation. 95. 2567-2572 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yukihito Higashi: "Relationship between insulin resistance and endothelium-dependent vascular relaxation in patients with essential hypertension" Hypertension. 29. 280-285 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yukihito Higashi: "Nocturnal decline in blood pressure is attenuated by NaCl loading in salt-sensitive patients with essential hypertension" Hypertension. 30. 163-167 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yukihito Higashi: "Aging and severity of hypertension attenuate endothelium-dependent renal vascular relaxation in humans" Hypertenion. 30. 252-258 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mitsuisa Yoshimura: "Differential effects of extracellular Mg^<2+> entry in human coronary arterial endothelial cells" Arteriosclerosis, Thrombosis, and Vascular Biology. 17. 3356-3361 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ryoji Ozono: "Change in blood pressure during altered sodium intake in not associated with calciotropic hormone level" Clinical Science. 93. 153-157 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yukiko Nakano: "Angiotensin I-converting enzyme gene polymorphism and acute response to captopril in ssential hypertension" American Journal of Hypertension. 10. 1064-1068 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nobuo Sasaki: "Lack of effect of transmenmbrane gradient of magnesium and sodium on regulation of cytosolic free magnesium concentration in rat lymphocytes" Biochimica et Biophysica Acta. 1329. 493-198 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mitsuisa Yoshimura: "Extracellular Mg^<2+> inhibits capacitive Ca^<2+> entry in vascular smooth muscle cells" Circulation. 95,11. 2567-2572 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yukihito Higashi: "Relationship between insulin resistance and endothelium-dependent vascular relaxation in patients with essential hypertension" Hypertension. 29,1. 280-285 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yukihito Higashi: "Nocturnal decline in blood pressure is attenuated by NaCl loading in salt-sensitive patients with essential hypertension" Hypertension. 30,2. 163-167 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yukihito Higashi: "Aging and severity of hypertension attenuate endothelium-dependent renal vascular relaxation in humans" Hypertension. 30,2. 252-258 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mitsuisa Yoshimura: "Differential effects of extracellular Mg^<2+> on thrombin-induced and capacitative Ca^<2+> entry in human coronary arterial endothelial cells" Arteriosclerosis,Thrombosis,and Vascular Biology. 17,11. 3356-3361 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ryoji Ozono: "Change in blood pressure during altered sodium intake in not associated with calciotropic hormone level" Clinical Science. 93. 153-157 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yukiko Nakano: "Angiotensin I-converting enzyme gene polymorphism and acute response to captopril in essential hypertension" American Journal of Hypertension. 10,9. 1064-1068 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nobuo Sasaki: "Lack of effect of transmenmbrane gradient of magnesium and sodium on regulation of cytosolic free magnesium concentration in rat lymphocytes" Biochimica et Biophysica Acta. 1329. 493-498 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hiroyuki Hiraga: "Angiotcnsin 1-converting cnzyme gene polymorphism and salt sensitivity in csscntial hypertension" Hypertension. 27, 3. 569-572 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yukihito Higashi: "Renal response to 1-arginine in salt sensitive patients with essential hypertension" Hypertension. 27, 3. 643-648 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Norihisa Ono: "Platelet Ca^<2+> is not increased in stroke prone spontaneously hypertensive rats" Hypertension. 27, 6. 1312-1317 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mari Ishida: "Effects of insulin on calcium metabolism and platelet aggregation" Hypertension. 28, 2. 209-212 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Misuisa Yoshimura: "Potentiotion of the intracellular Ca^<2+> response to arginine vasopressin by increased cytosolic free Mg^<2+>" Biochemica et Biophysica Acta. 1312. 151-157 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ryoji Ozono: "Modulation of target tissue response to anglotensin II and sodium sensitivity in Japanese patients with essential hyperfension" Hypertension Research. 19, 3. 141-145 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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