| Project/Area Number |
08458014
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
体育学
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| Research Institution | UNIVERSITY OF TSUKUBA |
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Principal Investigator |
KONO Ichiro INSTITUTE OF HEALTH & SPORT SCIENCES,ASSOCIATE PROFESSOR, 体育科学系, 助教授 (00132994)
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| Co-Investigator(Kenkyū-buntansha) |
AKAMA Takao INSTITUTE OF CLINICAL MEDICINE,Assistant Professor, 臨床医学系, 講師 (60212411)
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| Project Period (FY) |
1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥7,300,000 (Direct Cost: ¥7,300,000)
Fiscal Year 1996: ¥7,300,000 (Direct Cost: ¥7,300,000)
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| Keywords | HUMAN DEFENSE SYSTEM / IMMUNE SYSTEM / SECRETARY IgA / NM CELL / CYTOKINE / EXERCISE / 運動 / 免疫 |
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| Research Abstract |
We investigated the effect of physical exercise on human defense mechanisms. Firstly we surveyed the recent research tendency focusing on the change of immune parameters after physical exercise. We found production of superoxide was influenced by exercise. We studied the usefulness of secretary IgA in saliva as, an indicator of human defense system. As saliva is obtained non-invasively, it might be a good tool to evaluate the human defense system in sports field. After intensive training camp, the IgA was elicited to decrease and NK cell activities was also found to decrease temporarily. We examined the change of cytokines after physical exercise. Interleukin 2 receptor and interleukin 6 receptor was found to decrease in plasma. Cytokines might play important role in the mechanisms of change of immune system by exersise stress. These results of this research might suggest that appropriate exercise enhance the human defense system.
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