| Project/Area Number |
08458252
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
HANDA Shizuo Tokyo Medical and Dental University, School of Medicine, Department of Biochemistry, Professor, 医学部, 教授 (00009987)
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| Co-Investigator(Kenkyū-buntansha) |
KASAMA Takeshi Tokyo Medical and Dental University, School of Medicine, Laboratory for Biomedic, 機器分析センター, 助教授 (80124668)
ROKUKAWA Chiaki Tokyo Medical and Dental University, School of Medicine, Department of Biochemis, 医学部, 技官
KUSHI Yasunori Tokyo Medical and Dental University, School of Medicine, Department of Biochemis, 医学部, 講師 (60177988)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥7,100,000 (Direct Cost: ¥7,100,000)
Fiscal Year 1997: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1996: ¥3,800,000 (Direct Cost: ¥3,800,000)
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| Keywords | lipoporysaccharide / ganglioside / glycolipid / peripheral nerve / autoimmune-antibody / Guillain-Barre syndrome / inner ear disorder / Fisher disease / CIDP / C.jejuni |
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| Research Abstract |
Glycosphingolipids are constituents of nerve cells that may serve as important antigens prticipating in humoral and cellular immune responses. Antibodies to glycolipids have been shown to be present in patients with variety of immune-mediated neurological disorders. In this research, we aimed to elucidate the significance of these autoantibodies and the roles of unique family of glycolipids as well as mechanisms that may under lie the immunopathogenesis of these disorders.
High anti-ganglioside antibodies titers are detected in patients suffering this disorders. We have demonstrated that gangliosides, which possess a common carbohydrate epitope with bacteria of the preceding infection are potential target antigens for the Guillain-Barre syndrome and Fisher disease. Various minor gangliosides can also be the target of antibodies in many other peripheral neuropathies. In patients with chronic inflammatory demyelinating polyneuropathy, high titer anti-sulfated glucuronosyl glycolipids were frequently detected. This high titer of antibody was not related with the presence of M-protein nor serum IgM value. We propose that polyneuropathy with IgM anti MAG/SGPG antibody form a subgroup of CIDP.Serum anti-glycolipids antibody activities in patients with Meniere's disease showed positive anti-sialylparagloboside antibody titers. by the chemical analysis of acoustic neurinoma samples, neolacto-series glycolipids were detected. These results indicate the significant roles of the anti-glycolipid antibody for the immunopathogenesis of these disorders.
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