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Development of A New Optical Resolution Method by Distilllation

Research Project

Project/Area Number 08554022
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Organic chemistry
Research InstitutionEhime University

Principal Investigator

TANAKA Koichi  Ehime University, Dept.of Applied Chemistry, Associate Prof., 工学部, 助教授 (10116949)

Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1996: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsOptical Resolution / Chiral Recognition / Enantiomer / Separation / Inclusion Crystal / Host Compound / Distilllation / キラル分離 / 不斉認識 / 包接化合物 / 光学活性体 / 光学異性体 / 包接 / ホストーゲスト銹体
Research Abstract

A new optical resolution method for enantiomers by simple distilllation in the presence of optically active host compounds has been developed. Optically active host compounds having high chiral recognition ability have also been designated and prepared. For expmple, 2-hexanol was found to be resolved very efficiently by simple distilllation in the presence of a new tartaric acid dimer host compound.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] F.Toda, K.Tanaka, C.F-Foces, L.Intantes, M.Claramunt, J.Elguero: "Host-Guest Chemistry. The Structure and Proton Disorder of the Three-Component crystal Fonned by 3(5)-Methyl-4-Nitropyrazole." J.Phys.Org.Chem.9. 611-618 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Tanaka, A.Moriyama, F.Toda: "New Preparative Method for Optically Active 2,2′-and 4,4′-Dihydroxybiphenyl derivatives." J.Chem.Soc.Perkin Trans.1. 603-604 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Tanaka, K.Tamura, F.Toda: "Molecular Aggregation of Alkyltrimethylammonium Bromide and Alcohol in the Solid State" Mol.Cryst.Liq.Cryst.278. 139-143 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] F.Toda, K.Tanaka, R.Kuroda: "Isolation of a Nearly Eclipsed chiral Rotamer of 1,2-Dichloroethane as an luclusion" J.Chem.Soc.,Chem.Commun.1227-1228 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] F.Toda, K.Tanaka, H.Miyamoto, H.Koshima, L.Miyahara, K.Hirotsu: "Formation of Racemic Compound Crystals by Mixing of Two Enautiomeric crystals in the solid state" J.Chem.Soc.,Perkin Trans.2. 1877-1885 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Tanaka, A.Moriyama, F.Toda: "Novel Chiral Recognition in Host-Guest Inclusion Complexes Depends on their Molar Ratios" J.Org.Chem.62. 1192-1193 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Tanaka, F.Toda: "Comprehensive Supramolecular Chemistry:Vol.6" Pergamon,Oxford, 966 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] F.Toda, K.Tanaka, C.Foces-Foces, L.Infantes, R.M.Claramunt, C.Lopez and J.Elguero: "Host-Guest Chemistry. The Structure and Proton Disorder of the Three-Component Crystal Formed by 3 (5) -Methyl-4-nitropyrazole, (R,R) - (-) trans-4,5-bis (hydroxydiphenylmethyl) -2,2-dimethyl-1,3-dioxolane and Toluene" J.Phys.Org.Chem.9. 611-618 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Tanaka, A.Moriyama and F.Toda: "New Preparative Method for Optically Active 2,2'-and 4,4'-Dihydroxybiphenyl derivatives. A New Chiral Host Compound 4,4'-Dihydroxy-2,2', 3,3', 6,6'-hexamethylbiphenyl" J.Chem.Soc., Perkin Trans.1. 603-604 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Tanaka, K.Tamura and F.Toda: "Molecular Aggregation of Alkyltrimethylammonium Bromide and Alcohol in the Solid State" Mol.Cryst.Liq.Cryst.278. 139-143 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Kai, H.Suzuki, N.Kanehisa, K.Tanaka and F.Toda: "Diverse Mode of Crystal Structures in the Host-Guest Complexes of Diols" Mol.Cryst.Liq.Cryst.278. 87-97 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] F.Toda, K.Tanaka, H.Miyamoto, H.koshima, I.Miyahara and K.Hirotsu: "Formation of Racemic Compound Crystals by Mixing of Two Enantiomeric Crystals in the Solid State. Liquid Transport of Molecules from Crystal to Crystal" J.Chem.Soc.Perkin Trans.2. 1877-1885 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Tanaka, A.Moriyama and F.Toda: "Novel Chiral Recognition in Host-Guest Inclusion Complexes Depends on their Molar Ratios : Efficient Resolution of 2,2'-Dihydroxy-1,1'-biphenyl Derivatives and CD Spectral Study of Inclusion Complex Crystals" J.Org.Chem.62. 1192-1193 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Koshima, E.Hayashi, T.Matsuura, K.Tanaka, F.Toda, M.Kato and M.Kiguchi: "Preparation, Structure and Discrimination of A Chiral Bimolecular Crystal by the Self-assembly of 3-Indolepropinic Acid and Phenanthridine" Tetrahedron Lett.38. 5009-5012 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Tanaka, A.Moriyama, F.Toda: "Novel Chiral Recognition in Host-Guest Inclusion Complexes Depends on their Molar Ratios:Efficient Resolution of 2,2'-Dihydroxy-1,1'-biphenyl" J.Org.Chem.62. 1192-1193 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] F.Toda, K.Tanaka, R.Kuroda: "Isolation of a Nearly Eclipsed Chiral Rotamer of 1,2-Dichloroethane as an lnclusion Crystal with a Chiral Host Compound" J.Chem.Soc.Chem.Commun.1227-1228 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] F.Toda, K.Tanaka, H.Miyamoto, K.Koshina, I.Miyahara, K.Hirotsu: "Formation of Racemic Compound Crystals by Mixing of Two Enautiomeric Crystals in the Solid state." J.Chem.Soc.Perkin Trans.2. 1877-1885 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Koshima, E.Hayashi, T.Matsuura, K.Tanaka, F.Toda, M.Kato, M.Kiguchi: "Preparation,Structure and Piscrimination of a Chiral Bimoleulen Crystal by Self-Assembly of 3-Indolepropionic Acid and Phenanthrd." Tetrahedron Lett.38. 5009-5012 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 田中耕一: "New preparative method for optically active 2,2′-and 4,4′-dihydnoxybiphenyl derivatives" J.Chem.Soc.,Perkin Traus.1. 603-604 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 田中耕一: "Host-Guest Chemistry,The structure and Proton Disorden of the Three-Componeut Crystal Forwed by 3(5)-Methyl-4-Nitropyrazol" J.Phys.Ong.Chem.9. 611-618 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 田中耕一: "Molecular Aggregation of Alkyltrimethy ammonium Browide and Alcohol in the Solid state" Mol.Cryst-Liq.Cryst.277. 139-143 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 田中耕一: "Extremely Long C-C Bonds in Strained 1,1,2,2-Tetraphevyl Cyclobutaareves" Acta.Cryst.C52. 177-180 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 田中耕一: "Couforwation of Acyclic Derivatives of 1,1,4,4-Tetrapluemyl-l,3-butadieue" Acta Cryst.C52. 118-122 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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