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USEFULNES OF LABORATORY HAIRLESS DOG IN THE DEVELOPMENT OF DERMAL MEDICINES AND COSMETICS

Research Project

Project/Area Number 08556049
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Applied veterinary science
Research InstitutionThe University of Tokyo

Principal Investigator

DOI Kunio  The University of Tokyo, Graduate School of Agricultural and Life Sciences, Professor, 大学院・農学生命科学研究科, 教授 (70155612)

Co-Investigator(Kenkyū-buntansha) KIMURA Tohru  Nihon Nosan Kogyo Co.Ltd, Research Center, Sinior Researcher, 中央研究所, 主任研究員
ITAGAKI Shin-ichi  The University of Tokyo, Graduate School of Agricultural and life sciences, Asso, 大学院・農学生命科学研究科, 助教授 (00159823)
NAKAYAMA Hiroyuki  The University of Tokyo, Graduate School of Agricultural and Life Sciences, Asso, 大学院・農学生命科学研究科, 助教授 (40155891)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥6,500,000 (Direct Cost: ¥6,500,000)
KeywordsLaboratory hailess dog / Sunscreens / Screening system / Hair growth stimulator / Anti-acne agent / Depigmenthing agent / Depressant of skin aging / 育毛剤 / 薬効評価素 / 発毛促進薬 / 紫外線 / 皮膚反応 / サンスクリーン剤
Research Abstract

Usefulness of laboratory hairless dog (LHD) which have been developed by us in the development of dermal medicines and cosmetics were investigated from the various viewpoints. The results of this study are summarized as follows.
1) The epidermis of LHD contained abundant melanocytes. Their skin clearly showed UV-induced changes such as senburn and suntan reactions.
2) Sunscreens effectively protected the skin of LHD from sunburn and suntan reactions induced by solar exposure or artificial UV-irradiation.
3) Neonatal LHD developed hair growth reactions following minoxidil treatment.
4) The spotted pigmentation occurring on the skin of adult LHD was depigmented by application of HQ.
5) LHD developed spontaneous comedons in the skin and the severity of these lesions subsided with the application of anti-acne agents.
6) Aging of the skin of LHD was delayed by all-trans-retinoic acid treatment.
These results strongly suggest that LHD is very useful laboratory animal in the development of dermal medicines and cosmetics.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] Kimura T: "Studies on development of hairless descendants of Mexican hairless dogs and their usefulness in dermatelogical science." Exp.Anim.45. 1-13 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Spontaneous comedones on the skin of hairless descendants of Mexican hairless dogs." Exp.Anim.45. 377-384 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "The effect of topical minoxidil treatment on hair follicular growth of neonatal hairless descendants of Mexican hairless dogs." Vet.Dermatol.8. 107-113 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Effects of indomethacin on sunburn and suntan reactions in hairless descendants of Mexican hairless dogs." Hisotol Histopathol.13. 29-36 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Efficacy of hydroguinone in the tre treatment of cutaneous hyperpigmentation in hairless descendants of Mexican hairless dogs." Lob.Anim.Sci.48. 469-475 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Effects of all-trans-retinoic acid on the dorsal skin of hairless dogs." Toxicol.Pathol.26. 595-601 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.: "Ohshima S.and Doi K.Haematological and serum biochemicl values in hairless and haired descendants of Mexican hairless dogs." Lab.Anim.26. 214-218 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.: "Ohshima S.and Doi K.The inheritance and breeding results of hairless descendants of Mexican hairless dogs." Lab.Anim.27. 55-58 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Responses of the skin over the dorsum to sunlight in hairless descendants of Mexiacn hairless dogs." Am.J.Vet.Sci.55. 199-203 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Age-related changes in skin color and histologic features of hairless descendants of Mexican hairless dogs." Am.J.Vet.Sci.55. 480-486 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Protective effects of sunscreens on sunburn and suntan reactions in cross-bred Mexican hairless dogs." Vet.Dermatol.5. 175-187 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "dorsal skin reactions to sunlight and artificial ultraviolet light in hairless descendants of Mexicam hairless dogs." Exp.Anim.44. 293-299 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ishii Y., Kimura T., Itagaki S.and Doi K.: "Ultrastructure of the dorsal skins of hairless descendants derived from Mexicam hairless dogs." Exp.Anim.44. 353-357 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.: "Studies on development of hairless descendants of Mexican hairless dogs and their usefulness in dermatological science." Exp.Anim.45. 1-13 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Spontaneous comedones on the skin of hairless descrendants of Mexican hairless dogs." Exp.Anim.45. 377-384 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "The effect of topical minoxidil treatment on hair follicular growth of neonatal hairless descendants of Mexican hairless dogs." Vet.Dermatol.8. 107-113 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Effects of indomethacin on sunburn and suntan reactions in hairless descendants of Mexican hairless dogs." Hist.Histopathol.13. 29-36 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Efficacy of hydroquinone in the treatment of cutaneous hyperpigmentation in descendants of Mexican hairless dogs." Lab.Anim.Sci.48. 469-475 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Effects of all-trans-retinoic acid on the dorsal skin of hairless dogs." Toxicol.Pathol.26. 595-601 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura T.and Doi K.: "Spontimeous comedones on the skin of hairless ckscendonts of Maxicon hairless dogs." Exp.Anim.45. 337-384 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kimura T.and Doi K.: "The effect of topical minoxidil treatment on hair fdticular growth of neonatal hairless descendonts of Mexican hairless dogs." Vet.Dermatol.8. 107-113 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kimura T.and Doi K.: "Efficacy of hydroquinone in the treatment of cutaneous hyperpigmentation in hairless descendonts of Mexican hairless dogs." Lab.Anim.Sci.48. 469-475 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kimura T.and Doi K.: "Effect of indomethacin on sunburn and suntan reactions in hairless descendonts of Mexican hairless dogs." Histol.Histopathol.13. 29-36 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kimura T.and Doi K.: "Effects of all trons-retinoic acid on the dorsal skin of hairless dogs." Toxicol.Pathol.26. 595-601 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kimura T.& Doi K.: "Effects of all trans-retinon acid on the dorsal skin of hairless dogs." Toxicol.Pathol.26(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kimura T.& Doi K.: "The effect of topical minoxidil treatment on hair follicular growth of neonatal of hairless descendonts of Mexican kairless dogs." Vet.Dermatol.8. 107-113 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ishii Y, Kimura T., Itagaki S. & Doi K.: "The skin ingry induced by high energy does of ultraviolet in haieless Aescendonts of Mexican fairless dogs." Hist.Histopathol.12. 383-389 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kimura T.& Doi K.: "Spontoneon's comedones on the skin of hairless descondonts of Mekicon hairless dogs." Exp.Anim.45. 377-384 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kimura T.and Doi K.: "Responses of the skin over the dorsum to sunlight in hairless descendants of Mexican hairless dogs" Am.J.Vet.Res.55. 199-203 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kimura T.and Doi K.: "Protective effects of sunscreens on sunburn and suntan reactions in cross-bred Mexican hairless dogs." Vet.Dermatol.5. 652-656 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kimura T.and Doi K.: "Dorsal skin reactions to sunlight and artificial ultraviolet light." Exp.Anim.44. 293-299 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kimura T.and Doi K.: "Spontaneous comedons on the skin of hairless descendants of Mexican hairless dogs." Exp.Anim.45. 377-384 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kimura T.and Doi K.: "The effect of topical minoxidil treatment on hair follicular growth of neonates of hairless descendants of Mexican hairless dogs." Vet.Dermatol.7(in press). (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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