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NEW APPROACH FOR DIAGNOSIS AND TREATMENT OF NEUROLOGY IN COMPANION ANIMALS.

Research Project

Project/Area Number 08556052
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Applied veterinary science
Research InstitutionYAMAGUCHI UNIVERSITY

Principal Investigator

TOKURIKI Mikihiko  YAMAGUCHI UNIVERSITY,FACULTY OF AGRICULTURE,PROFESSOR, 農学部, 教授 (60012001)

Co-Investigator(Kenkyū-buntansha) TAURA Yasuho  YAMAGUCHI UNIVERSITY,FACULTY OF AGRICULTURE,PROFESSOR, 農学部, 教授 (80163153)
OHASHI Fumito  OSAKA PREFECTURE UNIVERSITY,FACULTY OF AGRICULTURE,PROFESSOR, 農学部, 教授 (10126013)
TOHYAMA Kojiro  IWATE MEDICAL UNIVERSITY,SCHOOL OF MEDICINE,ASSOCIATE PROFESSOR, 医学部, 助教授 (10129033)
OGAWA Hiroyuki  UNIVERSITY OF TOKYO,GRADUATE SCHOOL,PROFESSOR, 大学院農学生命科学研究科, 教授 (30012016)
UCHINO Tomiya  ANIMAL ME-RESEARCH CENTER,PRESIDENT, 所長(研究職)
冨澤 伸行 (富澤 伸行)  岩手大学, 農学部, 助教授 (00217530)
東儀 英夫  岩手医科大学, 医学部, 教授 (90155490)
針谷 敏夫  明治大学, 農学部, 助教授 (70135557)
太田 光明  大阪府立大学, 農学部, 助教授 (20134504)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥15,800,000 (Direct Cost: ¥15,800,000)
Fiscal Year 1998: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1997: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1996: ¥8,800,000 (Direct Cost: ¥8,800,000)
Keywordscompanion animals / aging / neurology / database / internet / 神経疾患 / 高齢動物 / 小動物 / 高齢化伴侶動物 / データベース構築 / コンピューター
Research Abstract

The first purpose of the research was to create the database for neurology in aged companion animals. Investigators working in the clinical field decided the itemized lists. This task was most important because the availability of the database depended on the lists. On the base of the lists, We made electronic information on neurology of aged small animals accumulated at the institutes of clinical investigators and created a concise database of 120 cases from which anyone was able to search a necessary data We used a file-maker, "Pro (4.0)" as a software of the database management and publicized it on the Internet, because we considered this database as a test trial. Anyone who was going to search what he wanted on neurology in small animals was possible to get an access to the database, as this software had an elementary function necessary to open on the web. This software could also give an authority to input data on neurology to researchers who were admitted by a password system. So, we think that we have been able to create a network, information management and searching system. This system will make it possible that every clinician in Japan becomes a joint owner about information of neurological diseases in aged companion animals and medical researchers can use the information as an animal model of neurology in aged people. We discussed about the limit of the Pro (4.0) and decided to use the Oracle as a software of the database when the database became too large.
The second one was to accumulate basic data for analyzing neurology. For example, we found that the transplant of the canine peripheral nerve to a dog was possibIe from the viewpoint of nerve regeneration and that the brainstem auditory potentials revealed a hearing disorder of aged marmoset.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (108 results)

All Other

All Publications (108 results)

  • [Publications] WADA N.: "Polysynaptic pathways from high threshold muscle…" Arch.Ital.Biol.134. 191-195 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] WADA N.: "Descending pathways from the medial longitudinal…" Arch.Ital.Biol.134. 207-215 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TOHGI H.: "Cerebrospinal fluid acetylcholine and choline…" J.Neural.Transm.(Budapest). 103. 1211-1220 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TOHGI H.: "The side and somatotopical location of single…" Eur.Neurol.36. 338-342 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TOHGI H.: "Development of large platelet aggregates from small…" Thromb.Haemostasis. 75. 838-843 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TOHGI H.: "Alpha-Tocopherol quinone level is remarkably low…" Neurosci.Lett.207. 5-8 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] MARUYAMA W.: "A dopaminergic neurotoxin, (R)-N-methylsalsolinol," Ann.Neurol.40. 119-122 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] KIATI W.: "Apoptosis in the aged dog brain" Acta Neuropathol. 92. 242-248 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] HARIGAYA T.…: "The mRNA expression of neurocan a brain-specific" Zool.Sci. 13. 665-668 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] NAKAICHI M.: "Primary brain tumors in two dogs treated by…" J.Vet.Med.Sci.58. 773-775 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] SAWASHIMA Y.: "Clinical and pathological findings of a Yorkshire" J.Vet.Med.Sci. 85. 659-651 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] HARADA T.: "Brain-stem auditory evoked potentials in the" J.Vet.Med.Sci.104. 43-50 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] HARADA T.: "Effects of click intensity and frequency on the" J.Vet.Med.Sci. 59. 561-567 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] WADA N.: "Discharge of cutaneous afferent fibers innervating…" Arch.Ital.Biol.135. 273-278 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] MIYATA H.: "Metabolic properties of the sensovy neurons in…" Arch.Ital.Biol.135. 263-271 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] KURATA K.: "Frequency selectivity on aspirin-induced hearing loss in rats with." J.Vet.Med.Sci. 59. 879-884 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] WADA N.: "Distribution of motoneurons innervating tail…" J.Vet.Med.Sci. 59. 473-475 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TAKAHASHI K.: "Rhythmical discharges recorded from cervical and…" J.Vet.Med.Sci. 59. 951-952 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TOHGI H.…: "Reduced size of right hippocampus in 39-to 80…" Neurosci.Lett.236. 21-24 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TOHGI H.…: "Reduction in the ratio of beta-preprotachykinin…" Brain Res.768. 86-90 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TOHGI H.: "Concentration of catecholamines and indoleamines in the cerebrospinal." J.Neural Transm.104. 441-449 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] YAMAMOTO M.: "Effects of tolcapone, a catechol-o-methyltransferase inhibitor." J.Neural Transm.104. 229-236 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TOHGI H.…: "Effects of CTG trinucleotide repeat expansion…" Muscle Nerve. 20. 232-234 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 〓ANASE.J.: "Effects of halothane and seroflurane on the electroretinogram." Am.J.Vet.Res. 58. 904-909 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] SATO K.: "Remyelination in the rat dorsal funiculus…" Neurosci.Res.28. 325-335 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] OHTANI N.: "Microdialysis study of hypothalamic modification…" J.Neurochem.69. 1622-1628 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] KII S.: "Magnetic resonance imaging of the lateral…" Vet.Radiol.Ultrasound.38. 430-433 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TOMIZAWA N: "A comparative study of medetomidine-butorphanol-katamine." J.Vet.Med.Assoc. 44. 189-194 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TAKAHASHI K.: "Effects of the lateral vestibulospinal tract on…" J.Vet.Med.Sci.60. 139-141 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] WADA N.: "Neuronal network from tail muscle afferents…" Brain Res.788. 327-331 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] UTSGISAWA K.: "Familial amyloid polyneuropathy related to transthyretin." Muscle and Nerve. 21. 1783-1785 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TAKAHASHI S.: "Cerebral blood flow and oxygen metabolism before and after" J.Neural Sci.158. 58-64 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TOHGI H.: "Alterations with aging and ischemia in nicotinic…" Brain Res.790. 186-190 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TOHGI H.: "Age-related changes in nicotinic acetylcholine…" Neurosci.Lett.245. 139-142 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] NISHIZUKA S: "Tissue-specific involvement of multiple mitochondrial DNA delections." Biochem.Bioph.Res.Co. 247. 24-27 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TOHGI H: "Cerebral blood flow and oxygen metabolism in senile dementia of Alzheimers" Neuroradiol.40. 131-137 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TOHGI H.: "Antithrombotic treatment in ischemic cerebrovascular disease" Internal Medicine. 37. 197-199 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TOHGI H.: "Age-related changes in D1 and D2 receptor mRNA expression in postmartem." Neurosci.Lett. 243. 37-40 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] C.TOHYAMA: "Long acellular nerve transplants for allogeneic grafting and the effects." Exp.Neurol. 154. 99-122 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] HIRANO N.: "Spread of swine hemagglutinating encephalomyelitis…" Adv.Exp.Med.Biol.440. 601-607 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] TAGA A.: "The advantage of magnetic resonance imaging…" J.Vet.Med.Sci.60. 1345-1348 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] KII S.…: "Developmental change of lateral venticular…" Vet.Radiol.Ultrasound.39. 185-189 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] HARADA T.: "Age-related changes in the brainstem auditory…" Hearing Res.128. 119-124 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 遠山稿二郎 他: "神経の再生と機能再建" 西村書店, 23 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 徳力幹彦 他: "獣医臨床病理学" 近代出版, 9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wada N.Sugita A.Hirao A.and Tokuriki M.: "Polysynaptic pathways from high threshold muscle afferent nerves innervation hindlimb muscles to tail motoneurons in the spinalized cat." Arch.Ital.Biol.134. 191-195 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wada N.Akenaga K.Takayama R.and Tokuriki M.: "Descending pathways from the medial longitudinal fasciculus and lateral vestibular nucleus to tail motoneurons in the decerebrate cat." Arch.Ital.Biol.134. 207-215 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tohgi H.Abe T.Kimura M.Saheki M.and Takahashi S.: "Cerebrospinal fluid acetylcholine and choline in vascular dementia of Binswanger and multiple small infract types as compared with Alzheimer-type dementia." J.Neural Transm. (Budapest). 103. 1211-1220 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tohgi H.Takahashi S.Takahashi H.Tamura K.and Yonezawa H.: "The side and somatotopical location of single small infarcts in the corona radiata and pontine base in relation to contralateral limb paresis and dysarthria." Eur.Neurol.36. 338-342 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tohgi H.Takahashi H.Watanabe K.Kuki H.and Shirasawa Y.: "Development of large platelet aggregates from small aggregates as determined by laser-light scattering : effects of aggregant concentration and antiplatelet medication [see comments]." Thromb.Haemostasis.75. 838-843 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tohgi H.Abe T.Saheki M.Yamazaki K.and Takahashi S.: "alpha-Tocopherol quinone level is remarkably low in the cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis." Neurosci.Lett.207. 5-8 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Maruyama W.Abe T.Tohgi H.Dostert P.and Naoi M.: "A dopaminergic neurotoxin, (R)-N-methylsalsolinol, increases in Parkinsonian cerebrospinal fluid." Ann.Neurol.40. 119-122 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kiatipattanasakul W.Nakamura S.Hossain M.Nakayama H.Uchino T.shumiya S.Goto N.and Doi K.: "Apoptosis in the aged dog brain." Acta Neuropathol.92. 242-248 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Harigaya T.Ogawa H.Tsunoda S.and Nagasawa H.: "The mRNA expression of neurocan, a brain-specific chondroitin sulfate proteoglycan, in neoplastic mammary glands in mice." Zool.Sci.13. 665-668 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakaichi M.Taura Y.Nakama S.Takeuchi A.Matsunaga N.Ebe K.and Amimoto A.: "Primary brain tumors in two dogs treated by surgical resection in combination with postoperative radiation therapy." J.Vet.Med.Sci.58. 773-775 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sawashima Y.Sawashima K.Taura Y.Shimada A.and Umemura T.: "Clinical and pathological findings of a Yorkshire Terrier affected with necrotizing encephalitis." J.Vet.Med.Sci.85. 659-661 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Harada T.and Tokuriki M.: "Brain-stem auditory evoked potentials in the common marmoset (Callithrix jacchus)" Electroen.clin.Neuro.104. 43-50 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Harada T.and Tokuriki M.: "Effects of click intensity and frequency on the brain-stem auditory evoked potentials in the common marmoset (Callithrix jacchus)" J.Vet.Med.Sci.59. 561-567 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wada N.Takahashi M.Tokuriki M.and Inoue M.: "Discharge of cutaneous afferent fibers innervating tail during passive tail movements in cats." Arch.Ital.Biol.135. 273-278 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miyata H.Joozaki A.Tokuriki M.and Kawai Y.: "Metabolic properties of the sensory neurons in the rat dorsal root ganglion." Arch.Ital.Biol.135. 263-271 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kurata K.Nishida N.Tsukuda R.Suzuki T.and Tokuriki M.: "Frequency selectivity on aspirin-induced hearing loss in rats with auditory stimulus-induced conditioned suppression." J.Vet.Med.Sci.59. 879-884 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wada N.Jouzaki A.Ichikawa M.Kaneto R.Takahashi K.Tokuriki M.Sugita S.: "Distributions of motoneurons innervating tail muscles in the pigeon." J.Vet.Med.Sci.59. 473-475 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takahashi K.Nishimura H.Wada N.and Tokuriki M.: "Rhythmical discharges recorded from cervical and trunk muscle nerves produced by stimulation of mesencephalic locomotor region (MLR) in the decerebrated cat." J.Vet.Med.Sci.59. 951-952 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wada N.Akenaga K.Takayama R.and Tokuriki M.: "Descending pathways from the medial longitudinal fasciculus and lateral vestibular nucleus to tail motoneurons in the decerebrate cat." Arch.Ital.Biol.134. 207-215 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tohgi H.Takahashi S.Kato E.Homma A.Niina R.Sasaki, K.Yonezawa H.and Sasaki M.: "Reduced size of right hippocampus in 39- to 80-year-old normal subjects carrying the apolipoprotein E epsilon4 allele." Neurosci.Lett.236. 21-4 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tohgi H.Utsugisawa K.Yoshimura M.Yamagata M.Nagane Y.and Saitoh K.: "Reduction in the ratio of beta-preprotachykinin to preproenkephalin messenger RNA expression in postmortem human putamen during aging and in patients with status lacunaris. Implications for the susceptibility to parkinsonism." Brain Res.768. 86-90 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tohgi H.Abe T.Saheki M.Yamazaki K.and Murata T.: "Concentration of catecholamines and indoleamines in the cerebrospinal fluid of patients with vascular parkinsonism compared to Parkinson's disease patients." J.Neural Transm. (Budapest). 104. 441-449 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamamoto M.Yokochi M.Kuno S.Hattori Y.Tsukamoto Y.Narabayashi H.Tohgi H.Mizuno Y.Kowa H.Yanagisawa N.and Kanazawa I.: "Effects of tolcapone, a catechol-O-methyltransferase inhibitor, on motor symptoms and pharmacokinetics of levodopa in patients with Parkinson's disease." J.Neural Transm. (Budapest). 104. 229-236 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tohgi H.Utsugisawa K.Kawamorita A.Yamagata M.Saitoh K.and Hashimoto K.: "Effects of CTG trinucleotide repeat expansion in leukocytes on quantitative muscle histopathology in myotonic dystrophy." Muscle Nerve. 20. 232-234 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yanase J.Ogawa H.: "Effects of halothane and sevoflurane on the electroretinogram of dogs." Am.J.Vet.Res.58. 904-909 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sato K.Ohmae E.Senoo E.Mase T.Tohyama K.Fujimoto E.Mizoguchi A.and Ide C.: "Remyelination in the rat dorsal funiculus following demyelination by laser irradiation." Neurosci.Res.28. 325-335 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohtani N.Sugino T.and Ohta M.: "Microdialysis study of hypothalamic modification of neurotransmitters in streptozotocin-diabetic rats." J.Neurochem.69. 1622-1628 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kii S.Uzuka Y.Taura Y.Nakaichi M.Takeuchi A.Inokuma H.and Onishi T.: "Magnetic resonance imaging of the lateral ventricles in Beagle-type dogs." Vet.Radiol.Ultrasound. 38. 430-433 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tomizawa N.Tomita I.Nakamura K.and Hara S.: "A comparative study of medetomidine-butorphanol-ketamine and medetomidine-ketamine anaesthesia in dogs." J.Vet.Med.Assoc.44. 189-194 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takahashi K.Wada N.and Tokuriki M.: "Effects of the lateral vestibulospinal tract on rhythmic discharges induced by stimulation of the mesencephalic locomotor region (MLR) in the decerebrated cat." J.Vet.Med.Sci.60. 139-141 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wada N.Takayama R.Kanda K.and Tokuriki M.: "Neuronal network from tail muscle afferents to hindlimb motoneurons in the spinalized cat." Brain Res.788. 327-331 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Utsugisawa K.Tohgi H.Nagane Y.Yamagata M.Saito K.and Mihara M.: "Familial amyloid polyneuropathy related to transthyretin mutation Val30 to Leu in a Japanese family." Muscle & Nerve.21. 1783-1785 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takahashi S.Tohgi H.Yonezawa H.Obara S.and Nagane Y.: "Cerebral blood flow and oxygen metabolism before and after a stroke-like episode in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)." J.Neurol.Sci.158. 58-64 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tohgi H.Utsugisawa K.Yoshimura M.Nagane Y.and Mihara M.: "Alterations with aging and ischemia in nicotinic acetylcholine receptor subunits alpha4 and beta2 messenger RNA expression in postmortem human putamen. Implications for susceptibility to parkinsonism." Brain Res.79. 186-190 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tohgi H.Utsugisawa K.Yoshimura M.Nagane Y.and Mihara M.: "Age-related changes in nicotinic acetylcholine receptor subunits alpha4 and beta2 messenger RNA expression in postmortem human frontal cortex and hippocampus." Neurosci Lett.245. 139-142 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nishizuka S.Tamura G.Goto Y.Murayama K.Konno T.Hakozaki M.Nonaka I.Tohgi H.and Satodate R.: "Tissue-specific involvement of multiple mitochondrial DNA deletions in familial mitochondrial myopathy." Biochem.Bioph.Res Co.247. 24-27 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tohgi H.Yonezawa H.Takahashi S.Sato N.Kato E.Kudo M.Hatano K.and Sasaki T.: "Cerebral blood flow and oxygen metabolism in senile dementia of Alzheimer's type and vascular dementia with deep white matter changes." Neuroradiol.40. 131-137 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tohgi H.Takahashi H.Utsugisawa K.and Sasaki K.: "Antithrombotic treatment in ischemic cerebrovascular disease [published erratum appears in Intern Med 1998 Mar ; 37 (3) : 346]" [Review] [10 refs] Internal Medicine.37. 197-199 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tohgi H.Utsugisawa K.Yoshimura M.Nagane Y.and Mihara M.: "Age-related changes in D1 and D2 receptor mRNA expression in postmortem human putamen with and without multiple small infarcts." Neurosci.Lett.243. 37-40 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] C.Tohyama K.Tajima K.Endoh K.Sano K.Tamura M.Mizoguchi A.Kitada M.Morihara T.and Shirasu M.: "Long acellular nerve transplants for allogeneic grafting and the effects of basic fibroblast growth factor on the growth of regenerating axons in dogs : A preliminary report." Exp.Neurol.154. 99-122 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hirano N.Tohyama K.and Taira H.: "Spread of swine hemagglutinating encephalomyelitis virus from peripheral nerve to the CNS." Adv.Exp.Med.Biol.440. 601-607 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taga A.Taura Y.Nishimoto T.Takiguchi M.and Higuchi M.: "The advantage of magnetic resonance imaging in diagnosis of cauda equina syndrome in dogs." J.Vet.Med.Sci.60. 1345-1348 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kii S.Uzuka Y.Taura Y.Nakaichi M.Inokuma H.and Onishi T.: "Developmental change of lateral ventricular volume and ratio in Beagle-type dogs up to 7 months of age." Vet.Radiol.Ultrasound.39. 185-189 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Harada T.Tokuriki M.and Tanioka Y.: "Age-related changes in the brainstem auditory evoked potentials of the marmoset." Hearing Res.128. 119-124 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] HARADA,T.,TOKURIKI: "Age-related changes in the brain-stem auditory evoked…" Hearing Res.in press.

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      1998 Annual Research Report
  • [Publications] UTUGISAKA,K.,TOHGI,H ;: "Familial amyloid polyneuropathy related to transthy retin…" Muscle & Nerve. 21(12). 1783-1785 (1998)

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  • [Publications] IDE,C.TOHYAMA,K.: "Long acelluar nerve transplants for allogenic…" Exp.Neurol.154. 99-112 (1998)

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      1998 Annual Research Report
  • [Publications] HASEGAWA,T., …HARIGAYA,T.: "Linear SRY transcript in equinetestis" J.Vet.Med.Sci.61(1). 97-100 (1999)

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      1998 Annual Research Report
  • [Publications] MASUMI,S.,OHTA,M.…: "Characteristics of nitrogen metabolism in rats …" Toxicol.(in press).

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      1998 Annual Research Report
  • [Publications] SUZUKI,T.,…TOMIZAWA,N.: "A possible role of nitric oxide formation in the …" J.Vet.Med.Sci.60(6). 691-697 (1998)

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  • [Publications] 内野富弥他: "イヌ・ネコの疾病統計-1990〜1997年の動向-" 株式会社インターズー, 191 (1999)

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  • [Publications] HARADA,T & TOKURIKI,M.: "Brain-stem auditoryeuoked potentials in the Common marmoset (Callithrix jacchus)" Electro encepholography & clinical Neurophysiology. 104(1). 43-50 (1997)

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  • [Publications] HARADA,T & TOKURIKI,M.: "Effects of click in tensity and frequency on the brain-stem auditory evoked potentials in the common marmoset (Callithrix jacchus)" Journal of Veterinary Medical Science. 59(7). 561-567 (1997)

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  • [Publications] TOHGI,H. et al.: "Reduction in the ratio of B-preprotachykinin to prepoenkephalin messenger RNA expression in postnortum human puthmen……" Brain Research. 768. 86-90 (1997)

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  • [Publications] TOHGI,H. et al.: "Reduced size of night hippocanpusim 39-to 80-year-old novemal" Neurosci Letter. 236. 21-24 (1997)

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  • [Publications] TOMIZAWA,N. et al.: "A comparative study of medetomidine-butorphanol-Katamine and medetomidine-Ketamine anaesthesia in dogs" Journal of Voterinary Medic. 189-194 (1997)

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  • [Publications] TOMIZAWA,N. et al.: "Chemical restraint of African lions with mede to midine・・・" Journal of Voterinary Medical Science. 59(4). 307-310 (1997)

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  • [Publications] OHTANI,N.: "Microdialysis study of hypothalamic modification of neurotransnlittevs…" J.Neurochem.(in press).

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      1996 Annual Research Report
  • [Publications] 遠山稿二郎: "共焦点レーザー顕微鏡像による三次元再構築" 三次元微小解剖. 2. 29-31 (1996)

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  • [Publications] 鈴木 満: "ラット海馬におけるoligodendrocyteの生後発達と髄鞘化過程" 神経組織の成長・再生・移植. 8・1. 11-12 (1996)

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  • [Publications] WADA,N.: "Polysynaptic pathways from high threshold muscle…" Arch.Ital.Biol.134. 191-195 (1996)

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      1996 Annual Research Report
  • [Publications] WADA,N.: "Descending pathways from the medial longitudinal…" Arch.Ital.Biol.134. 207-215 (1996)

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  • [Publications] HARIGAYA,T.: "The mRNA expression of neurocan,a brain-specific…" Zool.Sci.13. 665-668 (1996)

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      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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