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Peroxisome biogenesis and human peroxisome assembly disorders : Approches to prenatal diagnosis and gene therapy.

Research Project

Project/Area Number 08557011
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field General medical chemistry
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

FUJIKI Yukio  Kyushu Univ., Faculty of Science, Professor, 理学部, 教授 (70261237)

Co-Investigator(Kenkyū-buntansha) TSUNOO Hajime  Meiji Insutitute of Health Science, Director & Scientists, 所長, 研究者
TAMURA Shigehiko  Kyushu Univ., Faculty of Science, Research associate, 理学部, 助手 (90236753)
HARANO Tomoyuki  Kyushu Univ., Faculty of Science, Research associate, 理学部, 助手 (80037275)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥16,700,000 (Direct Cost: ¥16,700,000)
Fiscal Year 1998: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 1997: ¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1996: ¥6,600,000 (Direct Cost: ¥6,600,000)
Keywordsperoxisome / peroxisome-biogenesis disorders / CHO cell mutants / peroxin / patient gene analysis / AAA family / membrane protein / protein-protein interaction / トポロジー / 患者解析 / RINGフィンガー / 亜鉛イオン / 部位変異体
Research Abstract

With the support of this Grants-in Aid for Scientific Research 0 8 5 5 7 0 1 1 we obtained two major types of findings :
I) Isolation, characterization, and complementation group analysis of novel CHO cell mutants defective in peroxisome biogenesis
In addition to the previously isolated, three complementation groups (CGs) of peroxisome-deficient CHO cell mutants, ZP24, Z65, and ZP92, we isolated ZPlO7 (the same group as Z24), ZP1O5/ZP139, ZPIO9, ZP11O, ZP114, ZP119, ZP124, and ZP126, by the P9OH/UV method. CG analysis by PEX cDNA transfection and/or cell fusion with previously identified CGs of mutant cells, including 12 CGs of fibroblasts derived from patients with peroxisome biogenesis disorders (PBDs), revealed that ZP110, ZP114, and ZP126 are distinct from human CGs. Thus, it is evident that peroxisome assembly requires at least 15 gene-products.
II) Cloning of novel peroxin genes By genetic functional complementation assay of newly isolated CHO cell mutants, we cloned several peroxin cDNAs (PEXs), including PEX1, PEX12, and PEX19 for ZP1O7, ZP1O9, and ZP119, respectively. We then delineated that gene mutations in PEX1, PEX12, and PEX19 are responsible for PBDs of CG-I (E), CG-III, and CG-J, respectively. Moreover, we isolated PEX1O and PEX16 by expressed sequence tag (EST) DNA search using yeast genes and demonstrated that inactivation of PEX]O and PEX16 is the genetic cause of CG-VII (B) and CG-IX (D) PBDs, respectively. We also found two isoforms of the peroxin Pex5p (PTS 1 receptor) using CG-ll CHO mutants, ZP1O5 and ZP139. Impaired import of PTS1 proteins in the mutant cells was restored by both, shorter and longer, forms of Pex5p. More strikingly, the longer isoform of Pex5p was found to be involved in import of PTS2 proteins as well.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (74 results)

All Other

All Publications (74 results)

  • [Publications] Matuzono, Y.: "Human PEX19:cDNA cloning by functional complementation,mutation analysis in a Zellweger patient,and potential role in peroxisomal membrane assembly." Proc.Natl.Acad.Sci.USA.96. 2116-2121 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozawa, N.: "Genetic basis of peroxisome assembly mutants of humans, CHO cells and yeast:identification of a new complementation group of peroxisome biogenesis disorders,absent from peroxisomal membrane ghosts." Am.J.Hum.Genet.63. 1898-1902 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Honsho, M.: "Mutation in PEX16 is causal in the peroxisome-deficient Zellweger syndrome of complementation group D." Am.J.Hum.Genet.63. 1622-1630 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Imamura,A.: "Temperature-sensitive mutation in PEX1 moderates the phenotypes of peroxisome deficiency disorders." Hum.Mol.Genet.7. 2089-2094 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Abe, I.: "cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pexllp." Biochem.Biophys.Res.Commun.252. 529-533 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Abe, I.: "Clofibrate-inducible,28-kDa peroxisomal integral membrane protein is encoded by PEX11." FEBS Lett.431. 468-472 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamura, S.: "Human PEX1 cloned by functional complementation on a CHO cell mutant is responsible for peroxisome-deficient Zellweger syndrome of complementation group I." Proc.Natl.Acad.Sci.USA. 95. 4350-4355 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Otera, T.: "Peroxisome targeting signal type 1(PTS1)-receptor is involved in import of both PTS1 and PTS2:Studies with PEX5-defective CHO cell mutants." Mol.Cell.Biol.18. 388-399 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozawa, N.: "A novel mutation, R125X in peroxisome assembly factor-1 responsible for Zellweger syndrome." Hum.Mut.Suppl.1. S134-S136 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okumoto,K.: "PEX12 encodes an integral membrane protein of peroxisomes." Nature Genet.17. 265-266 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fujiki, Y.: "Molecular defects in genetic diseases of peroxisomes." Biochim.Biophys.Acta. 95. 235-250 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tateishi, K.: "Newly identified CHO cell mutants defective in peroxisome biogenesis represent two novel complementation group in mammals." Eur.J.Cell Biol.73. 352-359 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okumoto, K.: "Mutation in PEX10 is the cause of Zellweger peroxisome-deficiency syndrome of complementation group B." Hum.Mol.Genet.7. 1399-1405 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kinoshita, N.: "Newly identified Chinese hamster ovary cell mutants are defective in biogenesis of peroxisomal membrane vesicles(peroxisomal ghosts), representing novel complementation group in mammals." J.Biol.Chem.273. 24122-24130 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okumoto, K.: "PEX12,the pathogenic gene of group III Zellweger syndrome:cDNA cloning by functional complementation on a CHO cell mutant,patients analysis,and characterization of Pex12p." Mol.Cell.Biol.18. 4324-4336 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Imamura, A.: "Temperature-sensitive phenotypes of peroxisome assembly processes represent the milder forms of human peroxisome biogenesis disorders." Am.J.Hum.Genet.62. 1539-1543 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamura, S.: "A cytoplasmic AAA family peroxin,Pex1p,interacts with Pex6p." Biochem.Biophys.Res.Commun.245. 883-886 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozawa, N.: "Peroxisome biogenesis disorders:Identification of a new complementation group distinct from peroxisome-deficient CHO mutants and not complemented by human PEX13." Biochem.Biophys.Res.Commun.243. 368-371 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okumoto, K.: "Isolation and characterization of peroxisome-deficient Chinese hamster ovary(CHO)cell mutants representing human complementaion group III." Exp.Cell Res.233. 11-20 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Otera, T.: "Peroxisome targeting signal type 1(PTS1)-receptor is involved in import of both PTS1 and PTS2:Studies with PEX5-defective CHO cell mutants." Mol.Cell.Biol.18. 388-399 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tshukamoto, T.: "Isolation of a new peroxisome deficient CHO cell mutant defective in peroxisome targeting signal-1 receptor." Biochem.Biophys.Res.Commun.230. 402-406 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fujiki, Y.: "Approaches to studies on peroxisome biogenesis and human peroxisome-deficient disorders." Ann.N.Y.Acad.Sci.804. 491-501 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukuda, S.: "Human peroxisome assembly factor-2(PAF-2):A gene responsible for group C peroxisome biogenesis disorder in humans." Am.J.Hum.Genet.59. 1210-1220 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukuda, S.: "Correction by gene expression of biochemical abnormalities in fibroblasts from Zellweger patients." Pediat.Res.39. 812-815 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matuzono, Y.: "Human PEX19 : cDNA cloning by functional complementation, mutation analysis in a Zellweger patient, and potential role in peroxisomal membrane assembly." Proc.Natl.Acad.Sci.USA.96. 2116-2121 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozawa, N.: "Genetic basis of peroxisome assembly mutants of humans, CHO cells and yeast : identification of a new complementation group of peroxisome biogenesis disorders, absent from peroxisomal membrane ghosts." Am J.Hum.Genet.63. 1898-1902 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Honsho, M.: "Mutation in PEX16 is causal in the peroxisome-deficient Zellweger syndrome of complementation group D." Am J.Hum.Genet.63. 1622-1630 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Imamura, A.: "Temperature-sensitive mutation in PEX1 moderates the phenotypes of peroxisome deficiency disorders." Hum.Mol.Genet. 7. 2089-2094 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Abe, I.: "cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pex11p." Biochem.Biophys.Res.Commun. 252. 529-533 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Abe, I.: "Clofibrate-inducible, 28-kDa perxisomal integral membrane protein is encoded by PEX11." FEBS Lett.431. 468-472 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okumoto, K.: "Mutation in PEX10 is the cause of Zellweger peroxisome-deficiency syndrome of complementation group B." Hum.Mol.Gene.7. 1399-1405 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kinoshita, N.: "Newly identified Chinese hamster ovary cell mutants are defective in biogenesis of peroxisomal membrane vesicles (peroxisomal ghosts), representing a novel complementation group in mammals." J.Biol.Chem.273. 24122-24130 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okumoto, K.: "PEX12, the pathogenic gene of group III Zellweger syndrome : cDNA cloning by functional complementation on a CHO cell mutant, patients analysis, and characterization of Pex12p." Mol.Cell.Biol.18. 4324-4336 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Imamura, A.: "Temperature-sensitive phenotypes of peroxisome assembly processes represent the milder forms of humna peroxisome biogenesis disorders." Am J.Hum.Genet.62. 1539-1543 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamura, S.: "A cytoplasmic AAA family peroxin, Pex1p, interacts with Pex6p." Biochem.Biophys.Res.Commun.245. 883-886 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozawa, N.: "Peroxisome biogenesis disorders : Identification of a new complementation group distinct from peroxisome-deficient CHO mutants and not complemented by human PEX13." Biuochem.Biophys.Res.Commun.243. 368-371 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamura, S.: "Human PEX1 cloned by functional complementation on a CHO cell mutant is responsible for peroxisome-deficient Zellweger syndrome of complementation group I." Proc.Natl.Acad.Sci.USA. 95. 4350-4355 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Otera, T.: "Peroxisome targeting signal type 1 (PTS1)-receptor is involved in import of both PTS1 and PTS2 : Studies with PEX5-defective CHO cell mutants." Mol.Cell.Biol.18. 388-399 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozawa, N.: "A novel mutation, R125X in peroxisome assembly factor-1 responsibel for Zellweger syndrome." Hum.Mut.Suppl.1. S134-S136 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okumoto, K.: "PEX12 encodes an integral membrane protein of peroxisomes." Nature Genet.17. 265-266 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fujiki, Y.: "Molecular defects in genetic diseases of peroxisomes." Biochim.Biophys.Acta. 1361. 235-250 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tateishi, K.: "Newly identified CHO cell mutants defective in peroxisome biogenesis represent two novel complementation groups in mammals." Eur.J.Cell Biol.73. 352-359 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okumoto, K.: "Isolation and characterization of peroxisome-deficient Chinese hamster ovary (CHO) cell mutants representign human complementation group III." Exp.Cell Res.233. 11-20 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tsukamoto, T.: "Isolation of a new peroxisome deficient CHO cell mutant defective in peroxisome targeting signal-1 receptor." Biochem.Biophys.Res.Commun.230. 402-406 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fujiki, Y.: "Approaches to studies on peroxisome biogenesis and human peroxisome-deficient disorders." Ann.N.Y.Acad.Sci.804. 491-501 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukuda, S.: "Human peroxisome assembly factor-2 (PAF02) : A gene responsible for group C peroxisome biogenesis disorder in humans." Am J.Hum.Genet.59. 1210-1220 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimozawa, N.: "Correction by gene expression of biochemical abnormalities in fibroblasts from Zellweger patients." Pediat.Res.39. 812-815 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsuzono,Y.: "Human PEX19:cDNA cloning by functional complementation,mutation analysis in a Zellweger patient,and potential role in peroxisomal membrane assembly." Proc.Natl.Acad.Sci.USA.96. 2116-2121 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shimozawa,N.: "Genetic basis of peroxisome assembly mutants of humans,CHO cells and yeast:identification of a new complementation group of peroxisome biogenesis disorders,absent from peroxisomal membrane ghosts." Am.J.Hum.Genet.63. 1898-1902 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Honsho,M.: "Mutation in PEX16 is causal in the peroxisome-deficient Zellweger syndrome of complementation group D." Am.J.Hum.Genet.63. 1622-1630 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Imamura,A.: "Temperature-sensitive mutation in PEXI moderates the phenotypes of peroxisome deficiency disorders.disorders." Hum.Mol.Genet.7. 2089-2094 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Abe,I.: "cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pex11p." Biochem.Biophys.Res.Commun.252. 529-533 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Abe,I.: "Clofibrate-inducible,28-kDa peroxisomal integral membrane protein is encoded by PEXII." FEBS Lett.431. 468-472 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Okumoto,K.: "Mutation in PEX10 is the cause of Zellweger peroxixome-deficiency syndrome of coplermetal group B." Hum.Mol.Genet.7. 1399-1405 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kinoshita,N.: "Newly identified Chinese hamster ovary cell mutants are defective in biogenesis of peroxisomal membrane vesicles (peroxisomal ghost),representing a novel complementation group in mammals." J.Biol.Chem.273. 24122-24130 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Okumoto,K.: "PEX12,the pathogenic gene of group III Zellweger syndrome:cDNA cloning by functional complementation on a CHO cell mutant,patients analysis,and characterization of Pex12p." Mol.Cell.Biol.18. 4324-4336 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Imamura,A.: "Temperature-sensitive phenotypes of peroxisome assembly processes represent the milder forms of human peroxisome biogenesis disorders." Am.J.Hum.Genet.62. 1539-1543 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tamura,S.: "A cytoplasmic AAA family peroxin,Pexlp,interacts with Pex6p." Biochem.Biophys.Res.Commun.245. 883-886 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shimozawa,N.: "Peroxisome biogenesis disorders:Identification of a new complemetation group distinct from peroxisome-deficient CHO mutants and not complemented by human PEX13." Biochem.Biophys.Res.Commun.243. 368-371 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tamura,S.: "Human PEX1 cloned by functional complementation on a CHO cell mutant is responsible for peroxisome-deficient Zellweger of complemtation group I." Proc.Natl.Acad.Sci.USA. 95. 4350-4355 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tamura,S.: "Human PEX1 cloned by functional complementation on a CHO cell mutant is responsible for peroxisome-deficient Zellweger syndrome of complementation group I." Proc.Natl.Acad.Sci.USA. 95(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Otera,T.: "Peroxisome targeting signal type 1(PTS-1)-receptor is involved in import of both PTS-1 and PTS-2protein:Studies with PEX5-defective CHO cell mutants." Mol.Cell.Biol.18. 388-399 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Okumoto,K.: "PEX12 encodes an integral membrane protein of peroxisomes." Nature Genet.17. 265-266 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Fujiki,Y.: "Molecular defects in genetic disease of peroxisomes." Biochim.Biophys.Acta. 1361. 235-250 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tateishi,K.: "Newly identified Chinese hamster ovary (CHO) cell mutants defective in peroxisome biogenesis represent two novel complementation groups in mammals." Eur.J.Cell Biol.73. 352-359 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Okumoto,K.: "Isolation and characterization of peroxisome-deficient Chinese hamster ovary (CHO) cell mutants representing human complementation group III." Exp.Cell Res.233. 11-20 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shimozawa,N.: "A novel mutation,R125X in peroxisome assembly factor-1 responsible for Zellweger syndrome." Hum.Mut.(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tsukamoto,T.: "Isolation of a new peroxisome deficient CHO cell mutant defective in peroxisome targeting signal-1 receptor." Biochem.Biophys.230. 402-406 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Fujiki,Y.: "Approaches to Studies on Peroxisome Biogenesis and Human Peroxisome-deficient Disorders." Ann.N.Y.Acad.Sci.804. 491-501 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shimozawa,N: "Correction by Gene Expression of Biochemical Abnormalities in Fibroblast from Zellweger Syndrome.Pediatr." Pediatr.Res.39. 812-815 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Fukuda,S.: "Human peroxisome assembly factor-2(PAF-2):A gene responsible for group C peroxisome biogenesis disorder in humans." Am.J.Huma.Genet.59. 1210-1220 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 藤木幸夫: "特集によせて--特集「酸素毒」" 組織培養. 22. 123-124 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Fujiki,Y.: "In Membrane Proteins:Structure,Function and Expression Control(Mihara,K.and Hamasaki,N.eds.)" Karger Press, 53-61 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Fujiki,Y.: "Peroxisome Biogenesis:Topogenic Signal,Peroxisome Assembly Factor,and Zellweger Syndrome.In Membrane Protein Transport(S.Rothman,ed.)" Advances in Molecular and Cell Biology, 213-219 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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