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Research on Human Retrovirus as a Pathogenic Agents and its Treatment.

Research Project

Project/Area Number 08557019
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Experimental pathology
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

YOSHIKI Takashi  Hokkaido Univ.Sch.of Med., Pro., 医学部, 教授 (60220612)

Co-Investigator(Kenkyū-buntansha) IKEDA Hitoshi  Hokkaido Univ.Sch.of Med., Inst., 医学部, 助手 (20232192)
WAKISAKA Akemi  Hokkaido Univ.Sch.of Med., Ass.Pro., 医学部, 助教授 (90113646)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 1997: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1996: ¥5,500,000 (Direct Cost: ¥5,500,000)
KeywordsHTLV-I / Disease model / Transgenic rat / Apoptosis / HTLV-I / モデル動物 / TNFα / トランスジュニック / ラット
Research Abstract

Human T lymphocyte virus type I (HTLV-I) is associated with a number of diverse clinical disorders. To investigate the pathogenesis of the HTLV-I related disease, rats carrying HTLV-I (HAM rats) and those transgened with env-pX gene (env-pX rats) were investigated.
1) HAM rats develop a chronic progressive myelopathy after long incubation periods. The myelopathy is caused by demyelination based on apoptosis of oligodendrocytes. Microglias were infected with HTLV-I.High expression of pX mRNA and TNF-alpha is observed before apoptosis in the diseased spinal cord, while low of bcl-2.
2) env-pX rats develop a wide spectrum of collagen vascular and autoimmune diseases. Peripheral T lymphocytes of these rats express high amount of CD80/86 and ICAM-I showing high response to various antigens. The T lymphocytes infiltrated to the diseased organ/tissu were oligoclonal. Bone marrow transplantation experiments suggest that at least 3 types of pathogenic process are concerned to develop diseases.
3) Ick promotor env-pX rats show lymphoid tissue specific expression of pX mRNA.They develop thymomas but not ATL until now.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] Tomaru, U.: "Human T Lymphocyte Virus Type I-Induced Myeloneuropathy in Rats:Implication of LocalActivation of the pX and Tumor Necrosis Factor-α Genes in Pathogenesis." J.Infect.Dis.174. 318-323 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kishimoto, T.: "Phenotypescorrelating to metastatic properties of pancreas adenocarcinoma in vivo:The importance of surface Sialyl Lewisa antigen." Int.J.Cancer.69. 290-294 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamazaki, H.: "A wide spectrum of collagen vascular and autoimmune diseases in transgenic rats carrying the env-pX gene of human T lymphocyte virus type ・" Int.Immunol.9(2). 339-346 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Murata, K.: "In vivo retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for adult T cell leukemia in a rat model." Jpn.J.Cancer Res.88(5). 492-500 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shikishima, H.: "HTLV-・ pX transgenic rats:development of cytokine-producing mammary carcinomas and establishment of the pX mammary carcinoma cell lines." LEUKEMIA. 11(Suppl.3). 70-72 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshiki, T.: "Models of HTLV-・-induced diseases.Infectious transmission of HTLV-・-in inbred rats and HTLV-・ env-pX transgenic rats." LEUKEMIA. 11(Suppl.3). 245-246 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohya, O.: "HTLV-・ induced myeloneuropathy in WKAHrats:Apoptosis and local activation of the HTLV-・ pX and TNF-α genes implicated in the pathogenesis." LEUKEMIA. 11(Suppl.3). 255-257 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 吉木 敬: "ヒトレトロウイルス感染症の病理" 日本病理学会会誌. 86. 21-45 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sibata, M.: "Human Endogenous retroviruses:expression in various organs in vivo and its regulation in vitro." LEUKEMIA. 11(Suppl.3). 145-146 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ishizu, A.: "Interleukin-1 α regulates Thy-1 expression on rat vascular endothelial cells." Microvascul.Res.53. 73-78 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 吉木 敬: "膠原病-病理学的視点と展望" 監修 吉木 敬、小池隆夫、大河原章, 3-6 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tomaru, U.: "Human T Lymphocyte Virus Type I-Induced Myeloneuropathy in Rats : Implication of Local Activation of the pX and Tumor Necrosis Factor-alpha Genes in Pathogenesis." J.Infect.Dis.174. 318-323 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kishimoto, T.: "Phenotypescorrelationg to metastatic properties of pancreas adenocarcinoma in vivo : The importance of surface Sialyl Lewisa antigen." Int.J.Cancer. 69. 290-294 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamazaki, H.: "A wide spectrum of collagen vascular and autoimmune diseases in transgenic rats carrying the env-pX gene of human T lymphocyte virus type I." Int.Immunol.9 (2). 339-346 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Murata, K: "In vivo retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for adult T cell leukemia in a rat model." Jpn.J.Cancer Res.88 (5). 492-500 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shikishima, H.: "HTLV-I pX transgenic rats : development of cytokine-producing mammary carcinomas and establishment of the pX mammary carcinoma cell lines." LEUKEMIA. 11 (Suppl.3). 70-72 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshiki, T.: "Models of HTLV-I-induced diseases. Infectious transmission of HTLV-I in inbred rats and HTLV-I env-pX transgenic rats." LEUKEMIA. 11 (Suppl.3). 245-246 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohya, O.: "HTLV-I induced myeloneruopathy in WKAH rats : Apoptosis and local activation of the HTLV-L pX and TNF-alpha genes implicated in the pathogenesis." LEUKEMIA. 11 (Suppl.3). 255-257 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshiki, T.: "Pathology of the diseases caused by human retrovirus" Proc.Jpn.Soc.Pathol.86. 21-45 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sibata, M.: "Human Endogenous retroviruses : expression in various organs in vivo and its regulation in vitro." LEUKEMIA. 11 (Suppl.3). 145-146 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ishizu, A.: "Interleukin-1alpha regulates Thy-1 expression on rat vascular endothelial cells." Microvascul. Res.53. 73-78 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshiki, T.: "Collangen disease-Pathological View Points and its Future" Collagen Disease (ed. Yoshiki, T., Koike, T., Ohkawara, A.). 3-6 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamazaki,H.: "A wide spectrum of collagen vascular and autoimmune diseases in transgenic rats carrying the env-pX gene of human T lymphocyte virus type I." Int.Immunol.9. 339-346 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Murata,K.: "In vivo retrovirus-mediated herpes simplex virus thymidine Kinase gene therapy approach for adult T cell leukemia in a rat model." Jpn.J.Cancer Res.88. 492-500 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shikishima,H.: "HTLV-I pX transgenic rats: development of cytokine-producing mammary carcinomas and establishment of the pX mammary carcinoma cell lines." Leukemia.11. 70-72 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yoshiki,T.: "Models of HTLV-I-induced diseases.Infectious transmission of HTLV-I in inbred rats and HTLV-I env-pX transgenic rats." Leukemia. 11. 245-246 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohya,O.: "HTLV-I induced myeloneuropathy in WKAH rats: Apoptosis and local activation of the HTLV-I pX and TNF-α genes implicated in the pathogenesis." Leukemia. 11. 255-257 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 吉木 敬: "ヒトレトロウイルス感染症の病理" 日本病理学会会誌. 86・2. 21-45 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tomaru, U.: "Human T Iymphocyte type I-induced myelopathy in rats : Impolications of Iocal activation of the pX and tumor necrosis factor-α genes in pathogenesis." J Infect Dis. 174. 318-323 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamazaki, H.: "A wide spectrum of collagen vascular and autoimmune diseases in transgenic rats carryinng the env-pX gene of human T lymphocyte virus type I." Int Immurol. 9. 339-346 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sasaki. H.: "Central phenotype and related varieties of spinocerebellar ataxia 2 (SCA2) : a chinical and genetic study with a pedigree in the Japanese." J Neurol Sci. 144. 176-181 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sasaki. H.: "Clinical features and natural history of spinocerebellar ataxis type I." Acta Neurol Scand. 93. 64-71 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sanpei. K.: "Identification of the gene for spinocerebellar ataxia type 2 (SCA2) using a direct identification of repeat expansion and cloning." Nature Genet. 14. 277-284 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kishimoto, T.: "Phenotypes correlating to metastatic properties of pancreas adenocarcinoma in vivo : The importance of surface sialyl Lewis^a antigen." Int J Cancer. 69. 290-294 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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