| Project/Area Number |
08557053
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Pediatrics
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| Research Institution | Kurume University |
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Principal Investigator |
KATO Hirohisa Kurume University, Pediatrics, Professor, 医学部, 教授 (30080724)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Motoo Medico's Hirata Inc, Research Lab, Cheif, 研究課長
HASHINO Kanoko Kurume University, Pediatrics, Fellow, 医学部・小児科, 助手 (70237923)
SUGIMURA Tetsu Kurume University, Pediatrics, Fellow, 医学部・小児科, 助手 (80248400)
AKAGI Teiji Kurume University, Pediatrics, Staff, 医学部・小児科, 助手 (80231801)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 1997: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1996: ¥3,800,000 (Direct Cost: ¥3,800,000)
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| Keywords | patent ductus arteriosus / catheter intervention / congenital heart disease / coil / new devices / 動脈管開存 / コイル塞栓 / 血管内エコー法 / カテーテルインターベンション / コイル塞栓術 / 血管内皮細胞 |
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| Research Abstract |
1.Establishment of three dimensional model of patent ductus arteriosus
Using 30 post mortarn cardiac specimens, which complicated with patent ductus arteriosus, anatomical model of ductus was made by barium contented silicone rubber. Finally, three types of typical ductus arteriosus were made, such as 2,3 and 3 mm of minimum diameter of ductus. Using these casts, following studies were performed.
Development of a new system for ductus occlusion
Selection of metal materials for the new system were studied. and formation of different shapes of coils were manufactured. Deformation, endurance and flexibility of coils were evaluated in terms of different diameter of stainless wires, and different number of coil loops. Finally, appropriate endurance and flexibility of coils were obtained in case of the coils ware made by 0.038 inch wire. Additionally, we found that simultaneous double coil technique is very effective when the minimum diameter of ductus arteriosus was more than 3.0mm. Thus, we developed a 4 Fr end-hole multipurpose catheter for this double or triple coil technique.
Evaluation of occlusion mechanisms after coil occlusion of patent ductus arteriosus. At6 months to 1 years after the catheter closure of patent ductus arteriosus, intravascular echo studies were performed. Using this technique, endotherializaion around the implanted could be defined well. Such findings revealed that the long-term outcome of coil occlusion of this disease would be good outcome.
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