| Project/Area Number |
08557087
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | YOKOHAMA CITY UNIVERSITY |
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Principal Investigator |
KOSHINO Tomihisa SCHOOL OF MEDISINE,DEPARTMENT OF ORTHOPAEDIC SURGERY,PROFESSOR, 医学部, 教授 (90046029)
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| Co-Investigator(Kenkyū-buntansha) |
MACHIDA Jiro SCHOOL OF MEDISINE,DEPARTMENT OF ORTHOPAEDIC SURGERY,INSTRUCTOR, 医学部附属病院, 講師 (80244482)
和田 次郎 横浜市立大学, 医学部, 助手 (00220955)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥11,300,000 (Direct Cost: ¥11,300,000)
Fiscal Year 1998: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1997: ¥10,200,000 (Direct Cost: ¥10,200,000)
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| Keywords | hydroxyapatite / artificial bone / bone genesis / bone cement promoting bone genesis / arthroplasty / high tibial osteotomy |
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| Research Abstract |
1. We implanted hydroxyapatite(HA) cement into the diaphysis of tibia of 20 rabbits. Five rabbits were killed 1, 3, 6 and 12 weeks after the operation, and a series of three undecalsified specimens of tibia was made. The specimens were stained with toluidine blue and observed under a light microscopy. Quantitative evaluation for newly developed bony tissue was performed with the semiautomatic machine for histomorphometry (Affinity Index). In all specimens after 3 weeks, new bone bonded to the surface of the HA cement was observed. Affinity Index was higher in later groups. Taken together, good osteoconductivity was observed around HA cement. Hereafter, we intend to evaluate in long term examination.
2. Opening wedge high tibial osteotomy was performed in 9 knees using Hydroxyapatite block until 1998, and we investigated results of these cases in this study. Clinical sympton was significantly improved, and macroscopic fracture of hydroxyapatite block was not observed in radiograms. Femorotibial angle remained same angle corrected in operation. However, longer term follow up study should be required to determine the result of this procedure. Undecalcified sections were prepared from specimens taken from the surface of implants at removal of internal fixation performed 1 year after operation. Histological appearance showed no inflammatory reaction, and direct bone-implant incorporation without fibrous tissue encapsulation was observed. Bone ingrowth was observed in the pores of the hydroxyapatite block, and the results should be compared with that of specimens taken 2 or 3 years after operation.
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