| Project/Area Number |
08557094
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 展開研究 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
IKEDA Tsunehiko Kyoto Prefectural University of Medicine, Medicine, Ophthalmology, Associated Prof., 医学部, 助教授 (70222891)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKEBE Hiraku Kyoto Prefectural University of Medicine, Medicine, Radiology, Instructor, 医学研究科, 教授 (10028318)
TANO Yasuo Kyoto Prefectural University of Medicine, Medicine, Ophthalmology, Instructor, 医学部, 教授 (80093433)
|
|---|
| Project Period (FY) |
1996 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
|
| Budget Amount *help |
¥7,800,000 (Direct Cost: ¥7,800,000)
Fiscal Year 1998: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥3,700,000 (Direct Cost: ¥3,700,000)
|
|---|
| Keywords | ultraviolet / vitrectomy / retina / choroid / intraocular tumor / retinal pigment epitherium / diabetic retinopathy / proliferative vitreoretinopathy |
|---|
| Research Abstract |
We performed pars plana vitrectomy with intraocular ultraviolet irradiation system (LA-200 UV.wave length 365nm, Hayashi Tokei KK) and coagulated the retinal surface. The we examined the effects of this irradiation system by using biocular fundud examination and histopathological sections. The duration of irradiation were 30 sec(group 1), 3 min(group 2). 10 mio(group 3). In the group 1, we observed the serous retinal detachment, however the damage of choroid was relatively minimal. By using fluorescein fundus angiography. we observed the damage of retinal pigment epitherial layer, and histopathologically there were minimal change in the sensory retina and choroid. In the group 3, we observed the severe atrophy of choroid and retina and the color of irradiated retina turned pale. Histopathologically all retinal layers were disappeared and the damage of the choroid were remarkable.
With all oue results the intraocular ultraviolet irradiation caused the miminal damage to the retina and choroid with minimal power, however the severe damage with high power energy. There are some possibility that this intraocular ultraviolet irradiation system would be available to treat the intraocular proliferative diseases, such as proliferative vitreoretinopathy, proliferative diabetic retinopathy, retinal vein occlusion, and intraocular tumors, such as retinal hemangioma and choroidal hemangioma.
|
