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Functional Brain Mapping using 3D Positron Emission Tomography and functional Magnetic Resonance Imaging

Research Project

Project/Area Number 08558082
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Neuroscience in general
Research InstitutionTohoku University

Principal Investigator

ITOH Masatoshi  Tohoku University Cyclotron RI Center, Division of Nuclear Medicine, Professor, サイクロトロンRIセンター, 教授 (00125501)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Takehiko  Cyclotron RI Center, Div.of Nuclear Medicine, Research Chief, サイクロトロンRIセンター, 助手 (70238632)
NAKAMURA Takashi  Cyclotron RI Center, Div.of Radioprotection, Professor, サイクロトロンRIセンター, 教授 (70026029)
MIYAZAWA Tatsuo  Japan IBM inc, Tokyo Basic Research Institute, Senior Researcher, 副主任研究員
TAKAHASHI Akiyoshi  Tohoku University School of Medicine, Department of Radiology, Associate Prof., 医学部, 教授 (80148874)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 1997: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1996: ¥4,300,000 (Direct Cost: ¥4,300,000)
KeywordsBrain Activation / MRI / Brain Function / Positron Tomography / Blood Flow / Brain Imaging / 画像処理 / 画像再構成 / 磁気断層法
Research Abstract

The aim of this study is to establish a functional brain mapping approach using 3-D positron camera (PET) and functional magnetic resonance imaging (fMRI). A rapid 3D-image reconstruction (1 min per a block data of 63 slices) was achieved using parallel processing algorithm and Tohoku University Super Computer (SX4, NEC inc, Japan), (Ann Nucl Med, 1997). 3D-dynamic data acquisition after injection of ^<15>O labeled water enabled absolute cerebral blood flow calculation without arterial blood sampling (J Cereb Blood Flow Metabol, 1996). Radiation exposure to subjects could reduced to 1/10^<th> of usual 2D data sampling (J Nucl Med, 1997). Anatomical brain standardization software was developed using affine linear image transformation to a template PET image set. Accuracy of this system and the SPM96 was tested by comparing 20 Japanese and 20 British brain images and found that transformation was successful if non-linear transformation was applied. Several clinical researches were carried out using this system for PET and fMRI (Neurosurg Psychiat, 1997 ; J Intl Soc Life Info Sci, 1997 ; Am J Neuroradiol, 1997)

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (39 results)

All Other

All Publications (39 results)

  • [Publications] 井上 健太郎, 伊藤 正敏 他6名: "Activity in the parietal area during visuomotor learning with optical rotation" NeuroReport. 8・4. 3979-3983 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 藤原 竹彦, 伊藤 正敏 他10名: "Performance evaluation of a large axial field-of-view PET scanner:SET-2400W" Annals of Nuclear Medicine. 11・4. 4307-313 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.M Deloar, 伊藤 正敏 他6名: "Internal Dose Estimation Including the Nasal Cavity and Major Airway for Continuous Inhalation of Cl502,1502 and Cl150 Using the Thermoluminescent Dosimeter Method" Journal of Nuclear Medicine. 38・4. 1603-1613 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 目黒 謙一, 伊藤 正敏 他3名: "Striatal dopamine metabolism crrelated with frontotemporal glucose utilization in Alsheimer‘s disease:A double-traser PETS study" Neurology. 49・2. 941-945 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 山本 智, 伊藤 正敏 他5名: "Decreased cortical glucose metabolism correlates with hippocampal atrophy in Alzheimer‘s disease as shown by MRI and PET" J Neurol.Neurosurg Psychiat. 62・6. 596-600 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 樋口 真人, 伊藤 正敏 他7名: "Regional crerbral glucose utilization is modulated by the dosage of apoprptein E type 4 allel and α1-antichymotrupsin type A allele Alzheimer‘s disease" Neuroreport. 8・6. 2639-2643 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 伊藤 正敏, 宮崎 浩 他5名: "Functional analysis of the brain at rest studied by PET and EEG" J Intl Soc Life Info Sci. 15・2. 282-292 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Singh LN, 高橋 昭善: "Functional MR imaging of cortical activation of the cerebral hemispheres during motor tasks." American Jornal of Neuroradiology. 19.1. 2113-2197 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K Inoue, R Kawashima, K Satoh, S Kinomura, R Goto, M Koyama, M Sugiura, M Ito, H Fukuda: "A PET Study of Pointing With Visual Feedback of Moving Hands" J.Neurophysiol. 79. 117-125 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K Inoue, R Kawashima, K Satoh, S Kinomura, R Goto, M Sugiura, M Itoh and H Fukuda: "Activity in the parietal area during visuomotor learning with optical rotation" NeuroReport. 8. 3979-3983 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Fujiwara, T.Watanuki, S.Yamamoto, S.MIYAKE,M.Seo, S.Itoh, M.et al.: "Performance evaluation of a large axial field-of-view PET scanner : SET-2400W." Annals of Nuclear Medicine. 11, No.4. 307-313 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.M.Deloar, H.Watabe, T,Nakamura, Y.Narita, A.Yamadera, T.Fujiwara and M.Itoh: "Internal Dose Estimation Including the Nasal Cavity and Major Airway for Continuous Inhalation of C1502,1502 and C150 Using the Thermoluminescent Dosimeter Method." J Nucl Med. 38. 1603-1613 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Itoh M,Miyazaki H,Tashiro M,Xiang X-Z,Higuchi M,Iwata R,Ido T.: "Functional analysis of the brain at rest studied by PET and EEG" J Intl Soc Life Info Sci. 15 (2). 282-292 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Fijimoto T,Itoh M,Kumano H,Tashiro M,Ido T: "Whole-body metabolic map with positron emission tomography of a man after running." Lancet 348. No.9022. 266 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Watabe H,Itoh M,Cunningham V,Lammertsma AA,Bloomfield P,et al.: "Noninvasive quantification of rCBF using positron emission tomography" J Cereb Blood Flow Metab. 15. 311-319 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tashiro M,Xiang X-Z,Okamura N,Ishizaki H,Miyazaki H,Ishii K,Itoh M: "Three-dimensional PET : An approach in psychology" J Int Soc Life Informat Sci. 14 (2). 282-287 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Itoh M,Miyazaki H,Takahashi Y: "Imaging of mind using positron emission tomography" J Int Soc Life Informat Sci. 14 (1). 76-85 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Orihara H.Ishii K.Iwata R.Fujiwara T.Itoh M.: "Three-dimensional positron emission tomography imaging system and its application for medical use" Japanese Journal of Clinical Medicine.55 (8). 2148-55 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakamura H.Hishinuma T.Tomioka Y.Ishiwata S.Ido T.Iwata R.Funaki Y.Itoh M.et al.: "Effects of haloperidol and cocaine pretreatments on brain distribution and kinetics of [11C] methamphetamine in methamphetamine sensitized dog : application of PET to drug pharmacokinetic study" Nuclear Medicine & Biology.24 (2). 165-9 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakamura H.Hishinuma T.Tomioka Y.Ido T.Iwata R.Funaki Y.Itoh M.et al.: "Positron emission tomography study of the alterations in brain distribution of [11C] methamphetamine in methamphetamine-sensitized dog" Annals of the New York Academy of Sciences.801. 401-8 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Itoh M.Iwata R.Miyake M.Fujiwara T.Ido T.Nakamura T.: "Development of simple on-line [oxygen-15] water infuser" Japanese Journal of Nuclear Medicine. 33 (6). 663-7 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Fujiwara T,Mejia M,Itoh M,Yanai K,Meguro K,et al.: Quantitative imaging of [^<11>C] Benztropine in the human brain with graphic analysis and spectrl analysis. Myers R (eds) Quantification of brain function using PET. Academic Press, London, 317-320 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Itoh M,Warabe H,Miyake M,Hagisawa S,Fujiwara T,et al.: Noninvasive determination of arterial input of ^<15>O tracers, using a dual cutaneous beta-detector set above the radial artery Myers R (eds) ditto. Academic Press, London, 67-71 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Watabe H,Itoh M,Cunningham VJ,Lammertsma AA,Bloomfield PM,et al.: Noninvasive quantification of rCBF using positron emission tomography Myers R (eds) ditto. Academic Press, London, 191-195 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mejia MA,Itoh M,Watabe H,Fujiwara T,Nakamura T.: Quantitative noninvasive estimation of rCBF by using [150] water and PET.Myers R (eds) ditto. Academic Press, London, 206-208 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 藤原竹彦, 伊藤正敏, 他10名: "Performance evaluation of a large axial field-of-view PET scanner : SET-2400W" Annals of Neclear Medicine. 11・4. 4307-313 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.M.Deloar, 伊藤正敏, 他6名: "Internal Dose Estimation Including the Nasal Cavity and Major Airway for Continuous Inhalation of C1502,1502 and C150 Using the Thermoluminescent Dosimeter Method" Journal of Nuclear Medecine. 38・4. 1603-1613 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 力丸尚, 渡辺誠, 他: "Mapping of Energy Metabolism of Masticatory and Tongue Muscles during Gum Chewing by Using Positron Emission Tomography and ^<18>F-fluoro-D-deoxyglucose" Eupropean Journal of Nuclear Medicine. (submitted). (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 渡辺誠, 古屋良一, 他4名: "顎関節症(Temporomandibular Disorders)の診断と治療" 補綴誌. 41・1. 1-43 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 伊藤正敏, 宮崎浩, 他5名: "Functional analysis of the brain at rest studied by PET and EEG" J Intl Soc Life Info Sci. 15・2. 282-292 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 渡辺誠: "顎関節症の保存療法" 歯界展望/デンタルオリンピア'95。21世紀の歯科医療. 別冊. 123-127 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 織原彦之丞, 伊藤正敏, 他3名: "ポジトロンCTの3次元画像化システムとその医学への応用" 日本臨床. 55・4. 266-273 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 伊藤正敏他5名: "簡便な[^<15>O]注射水製造注入装置の開発" 核医学. 33・6. 663-667 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 伊藤正敏、長沢治夫他1名: "Functional Mappingの臨床応用。PETによる脳機能マッピング" Neurological Surgery. 24・9. 663-783 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 藤本敏彦、伊藤正敏他3名: "Whole-body metabolic map with positron emission tomography of a man after running" Lancet. 348・9022. 266 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 渡部浩司、伊藤正敏他6名: "Noninvasive quantification of rCBF using positron emission tomography." J Cereb Blood Flow Metab. 15・4. 311-319 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 藤原竹彦、伊藤正敏他5名: "SET-2400による3D-PETの有用性の評価" Medical Now. 26・4. 7-11 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 田代学、伊藤正敏他五名: "Three-dimensional PET : An approach in psychology." J Int Soc Life Informat Sci. 14・2. 282-287 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 伊藤正敏、渡部浩司他9名: "Quantification of brain function using PET" Myers R, Jones T. Academic Press, London, 443 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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