| Project/Area Number |
08558083
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 展開研究 |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | KYOTO UNIVERSITY |
|---|
Principal Investigator |
SHIBASAKI Hiroshi Kyoto University, Graduate School of Medicine, Professor, 医学研究科, 教授 (30037444)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TSUKADA Hideo Hamamatsu Photonics, Central Laboratory, Researcher, 研究員
IKEDA Akio Kyoto University, Graduate School of Medicine, Instructor, 医学研究科, 助手 (90212761)
NAGAMINE Takashi Kyoto University, Graduate School of Medicine, Instructor, 医学研究科, 助手 (10231490)
FUKUYAMA Hidenao Kyoto University, Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 (90181297)
YONEKURA Yoshiharu Fukui Medical School, Biomedical Center, Professor, 高エネルギー研究所, 教授 (60135572)
|
|---|
| Project Period (FY) |
1996 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
|
| Budget Amount *help |
¥18,600,000 (Direct Cost: ¥18,600,000)
Fiscal Year 1998: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1997: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1996: ¥10,900,000 (Direct Cost: ¥10,900,000)
|
|---|
| Keywords | positron emission tomography / animal / glucose metabolism / cerebral blood flow / motor / sensory / ラット / サル / 動物用PET / ブドウ糖代謝率 / 大脳皮質 / アセチルコリン / アルツハイマー病 / ハーダー腺 / アセチルコリンエステレース / 運動機構 / 随意運動 / 脳賦活試験 |
|---|
| Research Abstract |
We have studied the central motor control mechanism using non-invasive procedures in human, such as positron emission tomography (PET), functional magnetic resonance imaging, magnetoencephalography, evoked potentials. To expand these research activities, we adopted the animal experiments, especially combined with PET and other electrophysiological examinations, based on our experience in collaborative study on animal PET among Kyoto University, Fukui Medical School and Hamamatsu photonics. On these backgrounds, we planned to build a new animal PET machine suitable for small animals, such as cat, rat and mouse, in order to study detailed mechanisms concerning the motor and sensory integration in normal and pathological movements. (1) We developed a new PET machine for animal use, with the spacial resolution, 3.5 x 3.5 x 4.5 mm in half width full maximum. The gantry was fixed so that we could have a large space around the scanner. (2) We verified the valid calculation method for glucose metabolic rate (CMRglc) in small animal with PET.As the large Harderian gland is located in front of and beneath the frontal lobe in rat or mouse, we measured the CMRglc in normal and Harderian glands resected rats, and found no remarkable effect of Harderian glands on CMRglc. (3) We exemplified the cholinergic and glutamatergic neurons to participate in the regulation of cerebral cortical neurons using animal PET.
|
