| Project/Area Number |
08558091
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tohoku University |
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Principal Investigator |
ABE Ken-ichi Grad.Sch.of Eng., Tohoku Univ., Prof., 大学院・工学研究科, 教授 (70005403)
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| Co-Investigator(Kenkyū-buntansha) |
YAMBE Tomoyuki Inst.of Development, Aging and Cancer, Assoc.Prof., 加齢医学研究所, 助教授 (70241578)
MATSUKI Hidetoshi Grad.Sch.of Eng., Tohoku Univ., Prof., 大学院・工学研究科, 教授 (70134020)
YOSHIZAWA Makoto Grad.Sch.of Eng., Tohoku Univ., Assoc.Prof., 大学院・工学研究科, 助教授 (60166931)
NITTA Shin-ichi Inst.of Development, Aging and Cancer, Prof., 加齢医学研究所, 教授 (90101138)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 1998: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1997: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1996: ¥9,700,000 (Direct Cost: ¥9,700,000)
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| Keywords | artificial heart / control / neural control / adaptive control / learning control / optimal control / total artificial heart / artificial circulation |
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| Research Abstract |
The purpose of this research was to develop a learning and adaptive control system of artificial hearts whose reference model is the cardiovascular center in the brain and to enable the system to carry out an artificial circulatory control, coping with the cardiovascular system whose structure and parameters are unknown and time varying.
First, a control algorithm of total artificial heart (Peripheral Vascular Resistance-Based Adaptive Control ; PVRBAC) was developed. This algorithm could make the controller be reflected by the autonomic nervous system via the peripheral vascular resistance (PVR). This may be because the decoupling control is used to remove the effect of the PVR on aortic pressure. This may enable the cardiovascular center to control cardiac output by manipulating the PVR.
Second, a controller for animal experiments based on the above algorithm was implemented in a personal computer system. An experimental system named effectively total artificial heart system was used to ascertain the adequacy of the PVRBAC.From this system, it could be shown that the contribution of right atrial pressure to heart rate was as good as that of aortic pressure. This implies that the PVRBAC is adequate because it uses the PVR consisting of both right atrial pressure and aortic pressure.
Third, it was shown that the PVRBAC is feasible for continuous-flow artificial heart as well as pulsatile-flow one. This indicates that the PVRBAC is versatile and does not depend on the kind of blood pump or drive type.
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