• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A Study on Implantable Retinal Implant using Cell Culture Technique

Research Project

Project/Area Number 08558097
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Biomedical engineering/Biological material science
Research InstitutionNagoya University

Principal Investigator

UCHIKAWA Yoshiki  Dept.of Computational Science and Eng., Prof., 工学研究科, 教授 (20023260)

Co-Investigator(Kenkyū-buntansha) WATANABE Masami  Institute for Developmental Research, Chief Researcher, 生理学部門, 主任研究員 (10093486)
YAGI Tohru  Dept.of Computational Science and Eng., Assistant Prof., 工学研究科, 助手 (90291096)
KODAMA Tetsuji  Dept.of Information Electronics, Assistant Prof., 工学研究科, 助手 (50262861)
KAWASE Kazuhide  Gifu University, School of Medicine, Assistant Prof., 医学部, 助手 (40234067)
松島 俊也  名古屋大学, 農学研究科, 助教授 (40190459)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥16,600,000 (Direct Cost: ¥16,600,000)
Fiscal Year 1998: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1997: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1996: ¥8,300,000 (Direct Cost: ¥8,300,000)
KeywordsRetinal Implant / Neural Cell Culture / Micro-machine / Artificial Organ / Visual Information Processing / 医用材料 / 失明 / 人工眼 / 細胞培養 / 神経移植 / ハイブリッド
Research Abstract

A hybrid retinal implant is a visual prosthesis to reconstruct visual sensation in the blind. It will consist of an outer apparatus and an implanted MBMS (micro-electro mechanical systems). In order to connect the MEMS with the CNS (central nervous systems) , several neurons will be cultured on the top of the MEMS.Then, their axons will be guided with the peripheral nerve fiber. After the axons reach towards the CNS, they will make the proper synaptic connection with the CNS neurons. Therefore, the adequate electrical stimulation will lead the neural cells to produce the action potential so that functional connection will be realized.
The visual prosthesis "Hybrid Retinal Implant requires to facilitate a micro-electrode array for extracellular stimulation of nervous systems. This time, using micro-machine technology, we have fabricated a prototype of the array. In this array, aluminum cable leads are sandwiched with two dielectric layers ; silicon dioxyside and silicon nitride. First, a … More 400 mum thickness silicon wafer was oxidized to a thickness of 1 mum. Conductors of aluminum were next deposited to a thickness of 0.3 mum and patterned. Then, the upper dielectric layer (i.e. silicon nitride) was deposited. Using a reactive ion etching process, silicon nitride layer was partially exposed to make electrode sites. This array consists of nine channel bipolar electrodes. Two adjacent electrodes are facing each other to make nine anode/cathode pairs in a 3x3 lattice. Each electrode has 20x20 mum square shape. The distance of each pair is up to 320 mum ; therefore, the cross-talk between each pair will be reduced. Our previous computational analysis have revealed that this specification of the micro-electrode array leads to the efficient electrical stimulation to neurons. In order to evaluate its real performance, in-vivo/in-vitro extracellular stimulation experiments will be performed in our next study.
For more information on this research, you may contact "http : //www. cmplx. cse. nagoya-u. ac. jp/research/retina/". Less

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] 内川嘉樹、八木 透: "ハイブリッド型人工網膜" 人工臓器. 127.5. 703-707 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 八木 透、内川嘉樹: "人工眼の開発状況" 神経眼科. 15、2. 170-174 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 八木 透、内川嘉樹: "人工網膜とその情報処理" Computer Today. 3、84. 16-21 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yagi et.al: "Computational Analysis on Extra-cellular Stimulation in Hybrid Retinal Implant" Investigative Ophthalmology & Visual Science. 39. S.9991- (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yagi,et.al.: "A study on hybrid artificial retina with cultured neural cells and semi-conductor micro device" Proc.1998 IEEE Int'l Joint Conf.on Newral Networks. 780-783 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Ito, T.Yagi, H.Kanda, S.Tanaka, M.Watanabe, Y.Uchikawa: "A culture of neurons on a micro-electrode array in hybrid retinal implant" Abstract of 1999 ARVO,Investigative Ophthalmology & Visual Science (IOVS). (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Yagi, Y.Ito, H.Kanda, S.Tanaka, M.Watanabe, Y.Uchikawa: "A prototype of a micro-electrode array for hybrid retinal implant" Abstract of 1999 ARVO,Investigative Ophthalmology & Visual Science (IOVS). (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] H.Kanda, T.Yagi, Y,Ito, S.Tanaka, Y.Uchikawa: "Toward visual prosthesis : Electrical Stimulation on the central nervous system" Proc.of 1999 Int.Sympo.on Non-Linear Eelctromagnetic Systems (ISEM'99). (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yagi, T., Ito, N., Watanabe, M., Uchikawa, Y.: "Toward Hybrid Retinal Implant : Evaluation of Electrode Array Using Hodgkin-Huxley ModeL" Abst.of 2nd Annual Vision Research Conference. 36. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yagi, T., Ito, N., Watanabe, M., Matsushima, T., Kawase, K., Uchikawa, Y.: "Computational Analysis on Extracellular Stimulation in Hybrid Retinal Implant" Abstract of 1998 ARVO,Investigative Ophthalmology & Visual Science (IOVS). Vol.39, No.4. S9991 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yagi, T., Ito, N., Watanabe, M., Matsushima, T., Uchikawa, Y.: "A Computational Study on an electrode Array in a Hybrid Retinal Implant" Proc.of 1998 IEEE International Joint Conf.on Neural Networks (IJCNN'98). 780-783 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito, N., Shirahata, A., Yagi, T., Matsushima, T., Kawase, K., Watanabe, M., Uchikawa, Y.: "Development of Artificial Retina using Cultured Neural Cells and Photoelectric Device : A Study on Electric Current with Membrane Model" Proc.of The 4th International Conf.on Neural Information Processing (ICONIP'97). 124-127 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yagi, T., Ito, N., Matsushima, T., Ishikawa, Y., Kawase, K., Shirahata, A., Uchikawa, Y.: "Artificial Retina using Cultured Neural Cells and Photoelectric Device" Proc.of 7th International Conf.on Human-Computer Interaction (HCI'97). 109 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 内川嘉樹.八木 透: "ハイブリッド型人工網膜" 人工臓器. 127・5. 703-707 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 八木 透.内川嘉樹: "人工眼の開発状況" 神経眼科. 15・2. 170-174 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 八木 透.内川嘉樹: "人工網膜とその情報処理" Computer Today. 3,84. 16-21 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yagi,et.al.: "Computational Aralysis on Extra-cellular Stimulation in Hyblid Rotinal Inplant" Investigative Ophtalmology & Visual Science. 39. S.9991 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yagi,et.al.: "A study on hybrid artificial retina with cultuled neural cells and semi-conductor micro device" Proc.of 1998 IEEE lnt'l.Joint Conf.on Neural Networks. 780-783 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 八木 透,内川 嘉樹: "視覚代用臓器ハイブリッド型人工網膜" TESマガジン(トヨタ技術会発行). 48・3. 70-75 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 八木 透,内川 嘉樹: "人工網膜とその情報処理" Computer Today 3月号. 84. 16-21 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yagi T,Ito N,et.al: "A study in hybrid artificial retina with cultured neural cells and Semicorductor microder" Proc.of lnt'l Joint Couf.on NEural Networks. in press (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito N,Shirahata A, et al: "Development of artificial retina using cultued nearal cells and plotoelectric olevice" Proc.of the 4^<th> lnt'l Cont.on Neural lifo.Processing. 124-127 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 八木,松島,川瀬,伊藤,白幡,内川: "神経細胞培養技術を用いた体内埋め込み型人工網膜の開発" 日本神経回路学会第7回全国大会講演論文集. 188-189 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 八木,松島,川瀬,伊藤,白幡,内川: "視覚代用臓器「人工網膜」の開発" 平成8年度電気関係学会東海支部連合大会講演論文集. 664-664 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 八木,松島,川瀬,伊藤,白幡,内川: "体内埋め込み型人工網膜の開発" 第12回ヒューマン・インタフェース・シンポジウム論文集. 565-568 (1996)

    • Related Report
      1996 Annual Research Report

URL: 

Published: 1996-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi