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Biopsychological study on the role of striatum in learning behavior

Research Project

Project/Area Number 08610071
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 実験系心理学
Research InstitutionUniversity of Tsukuba

Principal Investigator

IWASAKI Tsuneo  Institute of Psychology University of Tsukuba, Professor, 心理学系, 教授 (70092509)

Co-Investigator(Kenkyū-buntansha) ICHITANI Yukio  Institute of Psychology University of Tsukuba, Associate Professor, 心理学系, 助教授 (80176289)
YAMADA Kazuo  Institute of Psychology University of Tsukuba, Research Associate, 心理学系, 助手 (30282312)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Keywordslearning / memory / striatum / acety1choline / gamma-aminobutyric acid / rat / ニコチン
Research Abstract

It is recently shown that the striatum (caudate-putamen) is associated with memory and learning processes. We have investigated in this study what neural circuit is concerned with performance of spatial memory tasks. Intrastriatal kainic acid administration producing neuronal cell death in the striatum caused severe deficits in radial arm maze and Morris water maze learning. On the other hand, intrastriatal injection of 6-hydroxydopamine, a selective catecholaminergic neurotoxin, did not have any clear disruptive effect on radial maze performance. These results suggest that neuronal cell bodies in the striatum are necessary for correct performance of these tasks while dopaminergic input into the striatum does not play an important role. We have further investigated whether learning deficits produced by intrastriatal kainic acid injection was ameliorated by systemic treatment of' agonists of gamma-aminobutyric acid (GABA) receptors and nicotinic acetyIcholine receptors. GABA-A receptor agonist significantly improved the radial maze performance in kainic acid-treated rats, but GABA-B receptor agonist did not. Nicotine, a nicotinic receptor agonist, did not have any effect on the performance. Results suggest that learning deficits in kainic acid-lesioned animals may partly come from the loss of striatal GABA neurons, and that a circuit containing GABA-A receptors in the brain plays an important role for the performance of radial maze task. The effect of muscarinic receptor agonist remains to be investigated in order to clarify the role of cholinergic receptors in the striatum.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] 小林剛史: "線条体の学習・記憶機能に関する研究の動向" 筑波大学心理学研究. 19. 91-96 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kawasaki,K.: "Corticosterone levels during extinction of runway response in rats." Life Sciences. 61. 1721-1728 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kawabe,K.: "Effects of intrahippocampal AP5 treatment on radial-arm maze performance in rats" Brain Research. 781. 300-306 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nonaka,H.: "Effects of early postnatal AF64A treatment on passive avoidance response and radial maze learning in rats." Japanese Journal of Psychopharmacology. 18. 39-44 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 岡内 隆: "線条体カイニン酸投与ラットにおける線条体細胞外アセチルコリンおよびドーパミンのin vivo 測定" 筑波大学心理学研究. 21. 37-44 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 高濱 祥子: "線条体興奮性アミノ酸投与ラットの行動特性に関する研究の概観" 筑波大学心理学研究. 21. 45-56 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takefumi Kobayashi et al.: "Functional roles of the striatum on learning and memory in rats : a review" Tsukuba Psychological Research. 19. 91-96 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Katsuyoshi Kawasaki et al.: "Corticosterone levels during extinction of runway response in rats" Life Sciences. 61. 1721-1728 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kouichi Kawabe et al.: "Effects of intrahippocampal AP5 treatment on radial-arm maze performance in rats" Brain Research. 781. 300-306 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiroi Nonaka et al.: "Effects of early postnatal AF64A,treatment on passive avoidance response and radial maze learning in rats" Japanese Journal of Psychopharmacology. 18. 39-44 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takashi Okauchi et al.: "In vivo measurement of extracellular levels of acetylcholine and dopamine in the striatum of rats treated with intrastriatal kainic acid : a microdialysis study" Tsukuba Psychological Research. 21. 37-44 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sachiko Takahama et al.: "A review on the behavioral characteristics of rats treated with excitatory amino acids into the striatum" Tsukuba Psychological Research. 21. 45-56 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kawabe,K.Iwasaki T: "Effects of intrahippocampal AP5 treatment on radial-arm maze performance in rats." Brain Research. 781. 300-306 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nonaka,H.Iwasaki T: "Effects of early postnatal AF64A treatment on passive avoidance response and radial maze learning in rats." Japanese Journal of Psychopharmacology. 18. 39-44 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kawabe,K.Iwasaki.T: "Intrahippocampal D-cycloserine improves MK-801-induced memory deficits : radial-arm maze performance in rats." Brain Research. 814. 226-230 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 池上将永,岩崎庸男: "脳内のニューロテンシンとドーパミンの相互作用に関する研究動向" 筑波大学心理学研究. 21. 1-11 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 岡内 隆,岩崎庸男: "線条体カイニン酸投与ラットにおける線条体細胞外アセチルコリンおよびドーパミンのin vivoの測定" 筑波大学 心理学研究. 21. 37-44 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 山田 一夫: "薬物依存における視床下部-下垂体-副腎皮質ストレス反応系の役割に関する研究の動向" 筑波大学 心理学研究. 21. 57-65 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kawasaki,K.: "Corticosterone levels during extinction of runway,response in rats." Life Sciences. 61. 1721-1728 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 佐々木 康成: "ラットの嗅内皮質の学習・記憶機能に関する研究の動向" 筑波大学心理学研究. 20. 31-40 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 安部 博史: "嗅周皮質の学習・記憶機能に関する研究の動向" 筑波大学心理学研究. 20. 1-7 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 山田一夫: "ラットの味覚嫌悪学習の日内変動" 筑波大学心理学研究. 19. 169-174 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 小林剛史: "線条体の学習・記憶機能に関する研究の動向" 筑波大学心理学研究. 19. 91-96 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山田郁子: "脳内セロトニン系損傷動物の情動行動に関する研究の動向" 筑波大学心理学研究. 19. 161-168 (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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