| Project/Area Number |
08651041
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
高分子合成
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
YOSHIDA Takashi Hokkaido Univ., Graduate School of Science, Associate Professer, 大学院・理学研究科, 助教授 (40166955)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Curdlan / Curdlan sulfate / Water insoluble / Graft copolymerization / Cross-linking / Anti-HIV activity / グラフト重合 / PMMA / ポリスチレン / 固体NMR / 分子量 / 硫酸化 / キスエイズウイルス作用 |
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| Research Abstract |
Curdlan sulfate was found to have potent anti-HIV activity and low cytotoxicity. For the synthesis of water-insoluble curdlan sulfate which has selective affinity of HIV absorption in the infected blood, graft copolymerization of MMA onto curdlan and sulfation of the obtained copolymers were carried out.On graft copolymerization initiated by cerium ammonium nitrate, graft copolymers having various grafting percentages were obtained. The resulting graft copolymers were sulfated with piperidine-N-sulfonic acid. When the graft copolymer having grafting percentage of 88% was sulfated with 2.5eq.of piperidine-N-sulfonic acid to give the corresponding sulfated graft copolymer having S content of 3.1%. The testing of selective removal of HIV from blood will be investigated.
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