Static exercise-induced increase in blood pressure in individuals with cervical spinal cord injuries
| Project/Area Number |
08670095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | University of Occupational and Environmental Health |
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Principal Investigator |
TAJIMA Fumihiro UOEH,Scholl of Med., A/prof., 医学部, 講師 (00227076)
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| Co-Investigator(Kenkyū-buntansha) |
OGATA Hajime UOEH,Scholl of Med., Prof., 医学部, 教授 (70122843)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1997: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1996: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Spinalcord injury / Quadriplegia / Sympathetic nerve / Central command / Static exercise / Blood pressure / Heat rate / Cate cholamin / Spinalcord injury / Blood pressure |
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| Research Abstract |
We evaluated the afferent and reflex pathways involved in the pressor response to static exercise in subjects with cervical spinal cord injuries (SCI) at C6 to C8 level. In these subjects.the descending supraspinal sympathetic neurons and afferent pathways from the contracting muscles to peripheral vessels via the medullary cardiovascular center are damaged. We measured the mean arterial blood pressure (MBP) , heart rate (HR) and plasma concentrations of norepinephrine (NE) , epinephrine (E) , renin activity, vasopressin, aldosterone and human atrial natriuretic peptide during a 2-min period of sustained contraction of biceps brachii muscle in 7 SCI subjects and 7 age-matched ablebodied control subjects. Static exercise resulted in a significant increase in MBP (P<0.05) in both SCI (pre-exercise ; 74.7 (]SY.+-。[) 2.2, static exercise ; 81.9 (]SY.+-。[) 4.1 mmHg) and control (pre-exercise ; 101.0 (]SY.+-。[) 4.2, static exercise ; 117.0 (]SY.+-。[) 4.9 mmHg). There was no change in HR during exercise in SCI,while HR increased (P<0.05) during exercise in control subjects (pre-exercise ; 68.7 (]SY.+-。[) 3.8, static exercise ; 76.0 (]SY.+-。[) 3.1 beats/min). There were no significant changes in the hormones in SCI throughout the experiment. Based on the significant rise in MBP during exercise in SCI,our results indicate the presence of a functional cardiovascular control system in SCI subjects, which regulates the pressor response to static exercise is independent of the cardiovascular medullary control center.
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Report
(3 results)
Research Products
(3 results)
