| Project/Area Number |
08670191
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Gunma University School of Medicine |
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Principal Investigator |
OYAMA Tetsunari Gunma University School Dept of Pathology Assoiate Professor, 医学部, 助教授 (50233622)
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| Co-Investigator(Kenkyū-buntansha) |
KASHIWABARA Kenji Gunma University School Dept of Pathology Assistant Teacher, 医学部, 助手 (80242634)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Breast / Atypical cystic lobule / Precursor Lesion / CyclinD1 / Lobular neoplasia |
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| Research Abstract |
Atypical cystic lobules display distinctive immunohistochemical characteristics :
All the atypical cystic lobules we examined exhibit identical characteristics. The majority of the atypical epithelial cells stained for keratin 19 and estrogen and progesterone receptors, and between ten and fifty percent of thecells stained for cyclin D1. The staining for keratin 19 also shows qualitative differences between atypical and normal cells. The abundant cytoplasm of the atypical columnar cells stained less intensely and displayd a more diffuse and granular pattern than the cytoplasm of normal cells. These findings contrast with those of normal terminal duct-lobular units and lobules altered by blunt duct adenosis and fibrocystic changes.
Atypical cystic lobules resemble ductal carcinoma in-situ :
Observations based on our gnoup of eleven cases harboring both atypical cystic lobules and low-grade ductal carcinomas in-situ reveal that the atypical lobules possess the same cytological and immunohistochemical characteristics as the corresponding fully developed carcinomas.
Atypical cystic lobules occur more frequently in tissue harboring carcinoma in-situ :
We discovered atypical cystic lobules in about one-third of specimens containing carcinoma in-situ but in only three percent of samples showing only fibrocystic changes. The three study groups have similar frequencies of conventional ductal hyperplasia, so we believe that variations in case selection and specimen sectioning do not account for the difference in the frequencies of atypical cystic lobules.
B : A cyclin Dl study of lobular neoplasia of the breast
Invasive lobular carcinoma comprises approximately ten percent of human mammary cancers, yet little is known about its molecular pathogenesis. Since cyclin D1 plays a role in the evolution of breast carcinomas of the ductal type, we hypothesized that this confirmed oncogene might also
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