| Project/Area Number |
08670241
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Niigata University |
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Principal Investigator |
OITE Takashi Niigata Univ.School of Medecine, Institute of Nephrology Dept.of Cellular Physiology, Professor and Director, 医学部, 教授 (60018744)
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| Co-Investigator(Kenkyū-buntansha) |
MORIOKA Tesuo Niigata Univ.School of Medecine, Institute of Nephrology Dept.of Cellular Physio, 医学部, 助教授 (00210146)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | renal glomerulus / mesangial cell / vascular endothelial cell / extracellular matrix / cell adhesion molecules / cell-cell interction / regulation of cell function / 混合培養 / メリンギウム細胞 |
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| Research Abstract |
In the glomerulus, the endocapillary region is a closed space surrounded by the glomerular basement membrane comprised of a capillary lumen, endothelial cells (ECs), mesangical cells (MCs), and mesangical matrices. Our working hypothesis is that loss of physical and functional regulation by intrinsicECs and/or matrices may induce MCs dysfunction, leading to the pathological changes such as proliferation, enhanced extracellular matrix synthesis, MCs migration and mesangical interposition in the capillary region. By the aid of reseach grant (No.08670241,1996-1997) from the Ministry of Education, Science and Culture, we have got the results summarized up as the followings ;
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