MECHANISM OF B-CELL POSITIVE SELECTION IN THE BURSA OF FABRICIUS
| Project/Area Number |
08670371
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Kumamoto University |
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Principal Investigator |
EKINO Shigeo KUMAMOTO UNIVERSITY SCHOOL OF MEDICINE,DEPARTMENT OF ANATOMY,LECTURER, 医学部, 講師 (30125273)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Immunity / B cell / the bursa of Fabricius / Maternalantibody / IgG / ファブリキウス嚢 / アポトーシス |
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| Research Abstract |
B-cell repertoire in the bursa of Fabricius is diversified by gene conversion. We speculate that mutated B cells would be selected in the bursa of Fabricius in situ by corresponding antigens derived from the gut. In our experiments, environmental antigens derived from the gut made immune complex with maternal IgG in the bursal follicles. The distribution of antigen-antibody complex showed dendritic appearances in the medulla of bursal follilces. These results suggest that antigen-antibody complex trapped by FDC (Follicular Dendritic Cells), plays an important role in positive selection of B cells in the bursa of Fabricius.
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Report
(3 results)
Research Products
(10 results)
