| Project/Area Number |
08670386
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | University of Tokyo |
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Principal Investigator |
UMEZAKI Masahiro (1997) University of Tokyo, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (30292725)
本郷 哲郎 (1996) 東京大学, 医学部, 助手 (90199563)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAZAWA Minato University of Tokyo, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (40251227)
HONGO Tetsuro Yamanashi Institute of Environmental Sciences, Chief Researcher, 主幹研究員 (90199563)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1997: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | developing countries / Papua New Guinea / biological samples / essential elements / toxic elements / food consumption pattern / malaria prevalence / modernization / 必須元素栄養 / 汚染元素曝露 / 鉄 / 水銀 / 亜鉛 |
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| Research Abstract |
Both deficiency of essential elements and excess exposure to toxic elements have long been concerned in relation to human health in the developed countries. For populations in developing countries, however, intake and exposure levels of trace elements have scarcely been evaluated in connection with their environmental factors which largely differ from those of the developed countries. Based on analyzes of biological samples(blood, hair, and urine)collected from several populations in Papua New Guinea, inter-population variations of nutritional status of essential elements and exposure levels of toxic elements were evaluated in connection with their environmental conditions, in particular, food consumption pattern, malaria prevalence, and degree of modernization. In the evaluations of zinc nutrition and iron nutrition connected with anemia, it was clarified that malaria infection had the important role to nutritional status of these essential elements and anemia. In addition, food consu
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mption pattern characterized by high dependency on plant foods also playd a significant influence in their trace element nutrition. The populations who keep more traditional lifestyle showed higher zinc intake. Iron nutrition was also sufficient in the most traditional populations and tended to be worsen among modernized populations. Among toxic elements, long-term exposure to methylmercury in fish eating populations was evaluated. Hair and blood mercury concentrations indicated that in heavy fisheating populations, although they are living in the areas remote from anthropogenic sources, methylmercury was accumulated to the level causing renal damage. On the other hand, urinary mercury level which was considered to be the indicator of exposure to inorganic or elemental mercury was increased to the levels of developed countries in modernizing populations. This study concludes that ecological conditions of each population play decisive roles in their intake and exposure levels of trace elements and that further analysis is needed to elucidate adverse effect of rapid modernization. Less
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