| Project/Area Number |
08670448
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | KYOTO PREFECTURAL UNIVERSITY OF MEDICINE |
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Principal Investigator |
OZASA Kotaro KYOTO PREFECTURAL UNIVERSITY OF MEDICINE,FACULTY OF MEDICIENE,ASSISTANT PROFESSOR, 医学部, 講師 (20204191)
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| Co-Investigator(Kenkyū-buntansha) |
DEJIMA Kenji KYOTO PREFECTURAL UNIVERSITY OF MEDICINE,FACULTY OF MEDICIENE,INSTRUCTOR, 医学部, 助手 (80217447)
TAKENAKA Hiroshi OSAKA MEDICAL COLLEGE,FACULTY OF MEDICIENE,PROFESSOR, 医学部, 教授 (40137162)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | JAPANESE CEDAR POLLINOSIS / IMMUNOLOGY / EPIDEMIOLOGY / IgE ANTIBODY / LIFESTYLE / ALLERGY |
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| Research Abstract |
Children of primary and junior-high schools in a rural town in the southern Kyoto Prefecture were examined for their symptoms and serum antigen-specific IgE antibody every May or June during 1994-98. Dispersion of Japanese cedar pollen was measured in the town by Durham's method, and the counts were 165, 5941, 663, 2007 and 799 during the years, respectively.
Proportion of sensitized children to Japanese cedar pollen (JCP) varied lVom 43 to 56% during 1994-98, and proportion of Japanese cedar pollinosis was 14-20%. The proportion was large in a large-dispersion year. Proportion of sensitized children to house dust mite (HDM) was rather constant, 39-43% during the same period. Children being positive to Japanese cedar pollen in a large-dispersion year (e.g. 1995) became negative again in a small-dispersion year (e.g. 1996).
Children observed in all the year of 1994-97 were 267, and prevalence (being sensitive to an antigen in the initial year) and incidence (becoming sensitive during the observation period) were determined. Poor ventilation (relative risk = 3.42, 95% confidence interval = 1.03-11.3) and using kerosene stove (RR = 3.42, 95% CI = 1.26-9.23) increased the risk of incident sensitization to HDM.Prevalent sensitization to both JCP and HDM, and incident sensitization to JCP were not associated with these environmental factors in a house.
Children who were born in October to January had an increased risk of sensitization to JCP, who were exposed to pollen within 6 months after birth. Dispersed pollen have been measured in Kyoto-city since 1982, the period during which the subjects were born. The measurement can be a surrogate for that in the town. Children who were born within 6 months before a large-dispersion spring had a high risk of sensitization than those who were born in the same period before a small- dispersion spring.
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