The effect of exposure to hazardous factors on higher function of central nervous system among aged persons

• Project/Area Number: 08670473
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Osaka Prefectural Institute of Public Health
• Principal Investigator: HIRATA Mamoru Osaka Prefectural Insititute of Public Health, Senior Researcher, 労働衛生部, 主任研究員 (60167608)
• Project Period (FY): 1996 – 1997
• Project Status: Completed (Fiscal Year 1997)
• Budget Amount: ¥1,200,000 (Direct Cost: ¥1,200,000); Fiscal Year 1997: ¥400,000 (Direct Cost: ¥400,000); Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
• Keywords: Hand arm vibration / Organic solvent / Lead / Aging / Higher function of central nervous system / Event-related potentials

Research Abstract

In order to clarify the effect of exposure to hand arm vibration, organic solvent and lead on higher fundtion of central nervous system among aged person, event-related potentials including P300 and NO-GO potential (NOGO-P) were measured among 60 patients with vibration syncrome (VS group) and 39 age-matched conttrols, 14 lead-exposed workers (Pb group) and 17 controls and 13 organic solvent-exposed (TX group) workers and 12 controls. Paradigm of task were push-botton to target image in P300 and no-push-botton to it in NOGO-P.P300 latencies of Vs group, Pb group and TX group were significantly prolonged compared with those of controls (p=0.002, p=0.0001, p=0.0006, respectively). NOGO-P latencies of VS groupp and TX group were significantly prolonged compared with those of controls (p-0.004, p=0.0034, respectively). These findings suggest that these hazardous factors affect on higher function of central nervous system of aged person.