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EFFECT OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON THE EXPRESSION OF GROWTH FACTORSAND THEIR RECEPTORS

Research Project

Project/Area Number 08670563
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionSAITAMA MEDICAL SCHOOL

Principal Investigator

OTA Shinichi  SAITAMA MEDICAL SCHOOL,MEDICAL DEPARTMENT,ASSINTANT PROFESSOR, 医学部, 助教授 (30185269)

Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsNSAID / PROSTAGLANDIN / HEPATOCYTE GROWTH FACTOR / HUMAN FIBLOBLAST / CYCLOOXYGENASE / 人胃・大腸線維芽細胞 / 非ステロイド系消炎鎮痛剤 / COX
Research Abstract

Effects of indomethacin, a NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID), on the expression of hepatocyte growth factor (HGF) were investigated using normal human gastric and colonic fibroblasts. Results are as follows ;
a.Human gastric and colonic fibroblasts produced HGF.
b.Prostaglandins (PGs) stimulated HGF production. The order of potency was PGE1 * PGE2 > PGI2 analogue.
c.Exogenous cAMP and cholera toxin increased HGF production.
d.PGEl increased cellular cAMP.
e.Among FGF,TGFalpha, EGF,TNF-alpha, and IL1-beta, only IL1-beta dramatically increased endogenous PGE2 production.
f.IL1-beta induced not cyclooxygenase (COX)-l but COX-2.
g.Indomethacin completely blocked IL1-beta-induced increase of PGE2.
h.IL1-beta increased HGF,which was prevented by indomethacin.
These results suggest that NSAIDs may inhibit PG-induced increase of HGF production by suppressing endogenous PG production. This may explain in part the mechanisms of gastric injury and suppression of colon carcinogenesis by NSAIDs.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] Hiromi Banba, Shinichi Ota, Akira Kato, Fukashi Matsuzaki: "Non steroidal-antl-inflammatory drugs may delay the repair of gastric mwo by sappressing prostaglamdir-mediatel increase of hepatocyte grouth foctor production." Biochemical and Biophysical Research Commumications. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] HIROMI BAMBA,SHINICHI OTA,AKIRA KATO, FUKASHI MATSUZAKI: "NONSTEROIDAL-ANTI-INFLAMMATORY DRUGS MAY DELAY THE REPAIR OF GASTRIC MUCOSA BY SUPPRESSING PROSTAGLANDIN-MEDIATED INCREASE OF HEPATOCYTE GROWTH FACTOR" (IN PRESS).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hiromu Bamba,shinichi ota,Akira kato,Fukashi Matsuzaki: "Non-steroidal-anti-inflammatory drugs may delay the repair of gastric nacosa by suppressing prostaglandin-mediated in crease of hypatocyte gnwth tador produdis" Biochemical and Biophysical Research Communications. (印刷中).

    • Related Report
      1997 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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