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Clinicopathologic and molecular biologic study on histogenesis and development of colorectal carcinoma

Research Project

Project/Area Number 08670596
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

TANAKA Shinji  Hiroshima University Medical Hospital, Research Associate, 医学部・附属病院, 助手 (00260670)

Co-Investigator(Kenkyū-buntansha) YOSHIHARA Masaharu  Hiroshima University School of Medicine, Associate Professor, 医学部, 助教授 (20211659)
HARUMA Ken  Hiroshima University School of Medicine, Assistant Professor, 医学部, 講師 (40156526)
SUMII Koji  Hiroshima University School of Medicine, Associate Professor, 医学部, 助教授 (00116609)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1997: ¥100,000 (Direct Cost: ¥100,000)
Fiscal Year 1996: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordscolorectal cancer / histogenesis / invasion / metastasis / Ki-67 / apoptosis / MUC-1 mucin / TGF-alpha / EGF receptor / MUC-1 ムチン / MUC-1 mucin / 表面型大腸癌
Research Abstract

Histogenesis and development of colorectal carcinoma : We examined Ki-67 labeling index (LI), apoptosis, MUC-1 and pS2 protein in both polypoid (P) and superficial (S) type of colorectal carcinoma. 1) Ki-67 LI in S type lesions was significantly higher than that in P type carcinomas. Apoptosis in P type lesions was significantly higher than that in S type carcinomas. These results show that S and P type of colorectal carcinoma are different in poliferative behavior. 2) Colorectal carcinomas revealed a high incidence of MUC-1 expression, however, colorectal adenomas showed almost zero incidence of MUC-1 expression. Regarding invasive carcinoma, MUC-1 expression is related to invasive/metastatic potential and prognosis. These results indicated that MUC-1 expression closely contributed to colorectal carcinogenesis and a useful indicator in predicting the invasive/metastatic potential and prognosis. 3) Colorectal carcinoma and hyperplastic lesions showed significantly higher incidence of p … More S2 protein expression than adenoma. pS2 protein showed a significantly higher incidence in lesions with polypoid appearance, lager size, location of right side colon and adenomatous lesion. pS2 protein suspected to be related to colorectal carcinogenesis and further studies are needed considering the relation to other various factors.
Mlignant potential of residual colorectal carcinoma after endoscopic resection :
We examined the effect of stimulation by high frequent electrocautery snare resection in colorectal carcinoma implanted in nude mouse. Evaluation of Ki-67 LI revealed that stimulation by high frequent electrocautery snare resection had the tumor acquired a higher proliferative activity than before resection. TGF-alpha and EGF receptor expression in several tumors stimulated by high frequent electrocautery snare resection showed a stronger intensity than those before resection. However, the intensity of VEGF,bFGF and type IV collagenase expression showed no significant change before and after resection. These results indicated that some of residual tumor after endoscopic resection may acquire a higher proliferative activity by stimulation by high frequent electrocautery snare reseciton. Less

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] 谷本 達郎 他: "早期大腸癌310病変の臨床病理学的検討〜表面型病変の特徴を中心に、" 広島医学. 49. 1388-1394 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 嶋本 文雄 他: "大腸のserrated adenomaにおけるsialy Le^X-iの免疫組織学的検討" 腫瘍マーカー研究会誌. 11. 17-18 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S. Tanaka, et al: "Ki-67 and transforming growth factor alpha (TGF-a) expression in colorectal recurrent tumors after endoscopic resection" Recent Advances in Gastroenterological Carcinogenesis. 1st ed.1079-1083 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] F. Shimamoto: "Cell proliferation in polypoid type and superficial type serrated adenomas of the colorectum" Recent Advances in Gastroenterological Carcinogenesis. 1st ed.773-778 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 田中 信冶 他: "大腸中分化腺癌の組織学的亜分類の臨床的意義〜悪性度評価における浸潤先進部組織型の重要性〜" 消化器内視鏡. 8. 923-929 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S. Tatsuta: "Combined expression of urokinase-type plasminogen activator and proliferating cell nuclear antigen at the deepest invasive portion correlates with colorectal cancer prognosis" Int J Oncology. 10. 125-129 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y. Hiraga: "Single carcinoma cells at the deepest invasive portion correlate with metastatic potential of advanced colorectal carcinoma" Int J Oncology. 10. 1141-1145 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] F. Shimamoto: "Pathogenesis of serrated adenoma of the colorectum : Implication for malignant progression." Molecular Pathology of Gastroenterological Cancer ; Application to clinical practice. 1st ed. 93-106 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 谷本 達郎: "大腸粘膜内癌におけるMUC-1ムチンにおける免疫組織学的検討" 消化器癌の発生と進展. 9. 505-510 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y. Hiraga: "Immunoreactive MUC1 expression at the deepest invasive portion correlates with colorectal cancer prognosis" Oncology. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] R. Aoki: "MUC-1 expression as a predictor of the curative endoscopic treatment of submucosally invasive colorectal carcinoma" Dis Colon Rectum. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M. Kunihiro: "Combined expression of HLA-DR antigen and proliferating cell nuclear antigen correlate with colorectal cancer prognosis" Oncology. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tanimoto T,et al.: "Clinicopathological analysis on 310 cases with early colorectal cancer with special reference to the characteristics of superficial type lesions." The Journal of the Hiroshima Medical Association. 49. 1388-1394 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimamoto F,et al.: "Immunohistochemical analysis on Sialy Le^x-i expression in colorectal serrated adenoma." Proceeding of tumor marker conference. 11. 17-18 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Tanaka, et al.: "Ki-67 and transforming growth factor alpha (TGF-a) expression in colorectal recurrent tumors after endoscopic resection." Recent Advances in Gastroenterological Carcinogenesis. I. 1079-1083 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] F.Shimamoto, et al.: "Cell proliferation in polypoid type and superficial type serrated adenomas of the colorectum." Recent Advances in Gastroenterological Carcinogenesis. I. 773-778 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tanaka S,et al.: "Clinical significance of histologic subclassification of colorectal moderately differentiated adenocarcinoma-usefulness of histology at the deepest invasive portion in predicting the malignant potential." Endoscopia digestiva. 8. 923-929 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Tatsuta, et al.: "Combined expression of urokinase-type plasminogen activator and proliferating cell nuclear antigen at the deepest invasive portion correlates with colorectal cancer prognosis." Int J Oncology. 10. 125-129 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Hiraga, et al: "Single carcinoma cells at the deepest invasive portion correlate with metastatic potential of advanced colorectal carcinoma." Int J Oncology. 10. 1141-1145 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] F.Shimamoto, et al: "Pathogenesis of serrated adenoma of the colorectum : lmplication for malignant progression." Molecular Pathology of Gastroenterological Cancer, Springer-Verlag, Tokyo. 93-106 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tanimoto T,Tanaka S,et al: "immunohistochemical expression of MUC-1 in intramucosal colorectal carcinoma." Journal of Japanese Research Society for Gastroenterological Carcinogenesis. 9. 505-510 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Hiraga, et al: "Immunoreactive MUC1 expression at the deepest invasive portion correlates with colorectal cancer prognosis." Oncology. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Kunihiro, et al: "Combined expression of HLA-DR antigen and proliferating cell nuclear antigen correlate with colorectal cancer prognosis." Oncology. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] R.Aoki, S.Tanaka, et al: "MUC-1 expression as a predictor of the curative endoscopic treatment of submucosally invasive colorectal carcinoma." Dis Colon Rectum. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Hiraga: "Single carcinoma cells at the deepest invasive portion correlate with metastatic potential of advanced colorectal carcinoma." Int J Oncology. 10. 1141-1145 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] F.Shimamoto: "Pathogenesis of serrated adenoma of the colorectum : Implication for malignant progression." Molecular Pathology of Gastroenterological Cancer ; Application to clinical practice. 1st ed. 93-106 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 谷本達郎: "大腸粘膜内癌におけるMUC-1ムチンにおける免疫組織学的検討" 消化器癌の発生と進展. 9. 505-510 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y.Hiraga: "Immunoreactive MUC1 expression at the deepest invasive portion correlates with colorectal cancer prognosis." Oncology. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] R.Aoki: "MUC-1 expression as a predictor of the curative endoscopic treatment of submucosally invasive colorectal carcinoma." Dis Colon Rectum. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Kunihiro: "Combined expression of HLA-DR antigen and proliferating cell nuclear antigen correlate with colorectal cancer prognosis" Oncology. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tatsuta S, Tanaka S, et al.: "Combined expression of urokinase-type plasminogen activator and proliferating cell nuclear antigen at the deepest invasive portion correlates with colorectal cancer prognosis" Int J Oncology. Vol.10. 125-129 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 谷本達郎、田中信治、他: "早期大腸癌310病変の臨床病理学的検討 〜表面型病変の特徴を中心に〜" 広島医学. 49・11. 1388-1394 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 嶋本文雄、田中信治、他: "大腸のSerrated adeusinaにおけるsialyl Lexiの免疫組織学的検討" 腫瘍マーカー研究会誌. Vol.11. 17-18 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tanaka S, et al: "Ki-67 and transforming growth factor alpha (TGF-α) expression in colorectal recurrent tumors after endoscopic resection" Recent Advances in Gastroenterological Carcinogenesis I. 1st ed.1079-1083 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shimamoto F.Tanaka S.et al: "Cell proliferation in polypoid type and superficial type serrated adenomas of the colorectum" Recent Advances in Gastroenterological Carcinogenesis I. 1st ed.773-778 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 田中信治、他: "大腸中分化腺癌の組織学的亜分類の臨床的意義 〜悪性度評価における浸潤先進部組織型の重要性〜" 消化器内視鏡. 8・7. 923-929 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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