| Project/Area Number |
08670654
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tokyo University |
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Principal Investigator |
ISHII Akira Faculty of Medicine Tokyo University Assistant Professor, 医学部・附属病院, 助手 (30272553)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAI Kohichi Faculty of Medicine Tokyo University Assistant Professor, 医学部・附属病院, 助手 (10156630)
TAKAISHI Toshiaki Faculty of Medicine Tokyo University Assistant Professor, 医学部・附属病院, 助手 (40154736)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Asthma / late asthmatic response / immediate asthmatic response / mast cell / T lymphocyte / mass cell deficient mouse / mouse / マスト細胞欠損マウス / T細胞欠損マウス / 遅発型反応 / I型アレルギー / W / W^V |
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| Research Abstract |
After ovalbumin inhalation in sensitized +/+ mice, immediate asthmatic response and late asthmatic response was observed. In sensitized w/wィイD1vィエD1 mice bronchoconstrictive response was not observed in IAR and weak in LAR. This result shows that mast cell might not play an important roll in late asthmatic response, but have some influence on late asthmatic response. Then, what cell does play an important roll in late asthmatic response? To resolve this question I examined the roll of T lymphocyte.
In sensitized mice lacking of T cell late asthmatic response was very weak. In mice which sensitized T cell were imported into, late asthmatic response was observed after ovalbumin inhalation. This result shows that T cell plays an important roll in late asthmatic response. Although the mechanism of airway hyperactivity is unknown, CD4+/T helper (TH2) cell is shown to be very important in many reports. But, in this experiment, between TH1 dominant C57BL6 and TH2 dominant BALB/c mouse there was no difference in late asthmatic response. About this point I will investigate further.
I think this experiment made clear the roll of mast cell and T cell.
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