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Acute response of lung mechanics to hypoxia and histamine

Research Project

Project/Area Number 08670663
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

MISHIMA Michiaki  KYOTO UNIVERSITY Chest Disease Research Institute Associate Professor, 胸部疾患研究所, 助教授 (60190625)

Co-Investigator(Kenkyū-buntansha) 越久 仁敬  京都大学, 胸部疾患研究所, 助手 (20252512)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Keywordslung resistance, / lung elastance, / histamine, / contractilc interstitial cell / 肺間質細胞 / 家兎 / 低酸素 / 肺レジスタンス / 肺エラスタンス
Research Abstract

The acute lung mechanical responses to hypoxia were studied in the open-chest, paralyzed and vagotomized rabbits (n=7) at different positive end-expiratory pressure (PEEP) levels (2,5 and 8hPa ; randomly arranged), and compared the results with those of histamine injection (n=5). The tracheal flow and pressure were measured during tidal mechanical ventilation (respiratory rete : 40/min). Total lung resistance (R<@D2L@>D2) and total lung clastance (E<@D2L@>D2) were calculated breath by breath using linear regression. The influence of difference in the viscosity between the hypoxic (10%O<@D22@>D2) and normoxic gas(25%O<@D22@>D2) on the E<@D2L@>D2 measurement was corrected. The ratio of the increased value to the baseline value of R<@D2L@>D2 and E<@D2L@>D2 was defined as Percent Increase Ratio (PIR-R<@D2L@>D2 and PIR-E<@D2L@>D2, respectively) The PIR-E<@D2L@>D2/PIR-R<@D2L@>D2 values in hypoxic trial were significantly larger than that in histamine trial at 2 hPa PEEP (hypoxia ; 0.91(]SY.+-。[)0.23, histamine ; 0.37(]SY.+-。[)0.065, P<0.05). The negative PEEP dependency was noted in terms of PIR-E<@D2L@>D2/PIR-R<@D2L@>D2 in hypoxic condition (PIR : 8.07(]SY.+-。[)4.22<@D1**@>D1,1.73(]SY.+-。[)0.78, PIR-E<@D2L@>D2/PIR-R<@D2L@>D2 : 0.91(]SY.+-。[)0.23<@D1**@>D1,0.23(]SY.+-。[)0.11 ; 2 and 8 hPa PEEP, respectively : <@D1**@>D1 : P<0.05 compared to 8 hPa). The increase of E<@D2L@>D2 at histamine injection has been explained to be mainly derived from the tissue distortion secondary to the bronchial constriction. Thus, our results suggest that the increase of E<@D2L@>D2 at low PEEP partially includes the tissue response independent of bronchial constriction, such as contractile interstitial cells and imply that this hpoxic response of the lung tissucis sensitive to the increase of parenchymal tethering at the high PEEP.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Mishima M: "Temporal responses of total and local lung impedances afteri.v. oleic acid in dogs." Respiration Physiology. 103. 177-185 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mishima M: "Assessment of local lung impedance by the alveolar capsule oscillator in dogs." Journal of Applied Physiology. 80(4). 1165-1172 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mishima M: "Validity of the random noise oscillation and body box system for the measurement of the respiratory impedance of small animals." Frontiers in Medical and Biological Engineering. 7(3). 163-175 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mishima M: "Resistive load and the phase difference between chest mouth flow in COPD." Frontiers in Medical and Biological Engineering. 8(1). 1-18 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 三嶋 理晃: "Kokyu 15(12)" 肺胞オシレーション法による換気力学, 1389-1394 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mishima M., Balassy Z,Bates JHT: "Temporal responses of total and local lung impedances after i.v.oleic acid in dogs." Respiration Physiology. 103. 177-185 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mishima M,Balassy Z,Bates JHT: "Assessment of local lung impedance by the alveolar capsule osillator in dogs." Journal of Applied Physiology. 80(4). 1165-1172 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mishima M,Kawakami K,Fukunaga T,Sugiura N,Hirai T,Oku Y,Fukui M,Chin K,Ohi M,Kuno K: "Validity of the random noise oscillation and body box system for the measurement of the respiratory impedance of small animals." Frontiers in Medical and Biological Engineering. 7(3). 163-175 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mishima M,Higashiya K,Kawakami K, Sugiura N,Sakai N,Hirai T,Oku Y,Chin K,Ohi M,Kuno K: "Resistive load and the phase difference between chest and mouth flow in COPD." Frontiers in Medical and Biological Engineering. 8(1). 1-18 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mishima M: Lung mechanics assessed by micro oscillation method.Kokyu 15(12), 1389-1394 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mishima M: "Temporal responses of total and local lung impedances after i.v.oleic acid in dogs." Respiration Physiology. 103. 177-185 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mishima M: "Assessment of local lung impodance by the alveolar capsule oscillator in dogs." Journal of Applied Physiology. 80(4). 1165-1172 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mishima M: "Validity of the random noise oscillation and body box system for the measurement of the respiratory impedance of small animals." Frontiers in Medical and Biological Engineering. 7(3). 163-175 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mishima M: "Resistive load and the phase difference between chest and mouth flow in COPD." Frontiers in Medical and Biological Engineering. 8(1). 1-18 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 三嶋理晃: "Kokyu 15(12)" 肺胞オシレーション法による換気力学, 1389-1394 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Michiaki Mishima et al.: "Assessment of local lung impedance by the alveolar Caspule Osillafor in alogo" Journal of Apphicl Physiology. 80(4). 1165-1172 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Michiaki Mishima et al.: "Temporal respondes of tatal and local impedance afters oleic acid in dogs" Respiration Rhysiology. 102. 195-203 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 三嶋理晃: "呼吸" レスピレーション・リサーチ・ファンデーション, 1511 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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