| Project/Area Number |
08670665
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | EHIME UNIVERSITY |
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Principal Investigator |
KOHNO Nobuoki EHIME UNIVERSITY School of Medicine, Lecturer, 医学部・附属病院, 講師 (80215194)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Akihito EHIME UNIVERSITY School of Medicine, Assistant Professor, 医学部, 助手 (30191513)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | LUNG CANCER / NON-SMALL CELL LUNG CANCER / PROGNOSTIC FACTOR / ANTI-MUC1 NATURAL AUTOANYTIBODY / MUC1 / KL-6 / 自己抗体 / 抗MUC1抗体 |
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| Research Abstract |
We found that there are natural autoantibodies against KL-6/MUC1 in sera from healthy volunteers. We tried to clarify the clinical significance of the anti-MUC1 natural autoantibodies in sera from patients with advanced stages of non-small cell lung cancer.
Subjects were 9 patients with clinical stage IIIB and 21 patients with clinical stage IV of non-small cell lung cancer. Controls were 60 healthy volunteers.
Serum level of the anti-MUC1 natural autoantibodies were 108(]SY.+-。[)25.6 U/ml (mean (]SY.+-。[) SD) in healthy volunteers and 32 (]SY.+-。[) 13 U/ml in lung cancer patients. In the lung cancer patients, theirsurvival time of patients with high serum level of the anti-MUC1 natural autoantibodies more than 32 U/ml was significantly longer than patients with low level of the natural autoantibodies :
These results clearly indicate that the serum level of anti-MUC1 natural autoantibodies is a novel prognostic factor for oatients with advanced stages of non-small cell lung cancer and that they might have anti-tumor effects against lung cancer.
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