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The signifficance of surfactant proteins in interstitial pneumonia and their clinical application

Research Project

Project/Area Number 08670672
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionSAPPORO MEDICAL UNIVERSITY

Principal Investigator

TAKAHASHI Hiroki  SAPPORO MEDICAL UNIVERSITY,SCHOOL OF MEDICINE,DEPARTMENT OF INTERNALMEDICINE ASSISTANT PROFESSOR, 医学部・内科学, 講師 (60231396)

Co-Investigator(Kenkyū-buntansha) KUROKI Yoshio  SAPPORO MEDICAL UNIVERSITY,SCHOOL OF MEDICINE,DEPARTMENT OF BIOCHEMSTRY ASSOCIAT, 医学部・生化学, 助教授 (70161784)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1997: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsPULMONARY SURFACTANT / SURFACTANT PROTEIN A / SURFACTANT PROTEIN D / INTERSTITIAL PNEUMONIA / RADIATION PNEUMONITIS / SEROLOGICAL DIAGNOSIS
Research Abstract

(1)Eighty-eight % of patients with interstitial pneumonia (IP) which complicated by collagen vascular diseases (CDV) showed that either surfactant protein (SP)-A or SP-D in sera was higher than their cut-off levels. In contrast, only 1.8% of patients without IP showed to be false positive. These results suggest the combination assay of SP-A and SP-D predominantly improves the serological diagnosis on IP complicated by CVD.
(2)WE investigated the relationship between chest CT findings and SP-D/SP-A ratio in patients with idiopathic interstitial pneumonia (IIP). The patients were divided into two groups ; Group A showed predominantly an irregular linear opacity pattern on CT and histologicaly severe fibrosis with a weakly type II cell regeneration, Group B showed predominantly a ground-glass opacity pattern and histologicaly mild or moderate fibrosis with a prominently type II cell regeneration. As a result, Group A showed a significantly high mean value of SP-D/SP-A ratio when compared to that in group B.This suggests the heterogeneity in the rate of SP-A and SP-D production by two different cell types, type II cells and Clara cells.
(3)We next investigated the relationship between serum SP-A levels and prognosis of patients with IIP.The IIP patients who died within 3 years showed significantly high SP-A concentrations when compard to the IIP patients who had been alive more than 3 years.
(4)We also investigated the relationship wih IP comlicated by irradiation therapy. The patients came to show the increased concentrations of SP-A and SP-D in sera when IP was complicated by the received irradiation therapy. Therefore, a monitoring of the serum concentrations might be a useful tool to detect an onset of radiation pneumonitis. In the experiment using radiation-exposed rats, it was comfirmed that the incerase in sera consists with an appearance of pathohistological findings to be characteristic of IP.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Honda Y et al: "Decreased contents of surfactant proteinA and D in BAL fluids of healthy smoker." Chest. 109. 1006-1009 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takahashi et al: "Lipid analysis and surfactant-assaciated protein expression in lung adenocarcimuma cells from pleural effusion." Respiration. 63. 390-396 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 永江 尚人: "肺サーファクタント蛋白質D(SP-D)の血清濃度測定キットの開発" 医学と薬学. 36. 803-808 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 本田 泰人: "肺疾患の診断における肺サーファクタント蛋白質D(SP-D)血清測定キットの有用性" 医学と薬学. 36. 809-815 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 阿部 庄作: "特集;びまん性肺疾患-病態解明と治療の進歩;特発性間質性肺炎の診断と治療;トピックス:特発性間質性肺炎におけるサーファクタント蛋白質の動態と活動性の指標" 内科. 77. 664-666 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nagae H et al.: "Sensitive enzyme-linked immunosorbent assay improved for the detection of human pulmonary surfactant protein D in sera." Clin Chim Acta. in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 阿部 庄作: "間質性肺炎の病態と治療" 安藤正幸監修,医療新社(分担執筆), 277 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Honda Y,Takahashi H,Kuroki Y,Akino T,Abe S.: "Decreased contents of surfactant proteins A and D in BAL fluids of healthy smokers." Chest. 109. 1006-1009 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hattori A,Kuroki Y,Katoh T,Takahashi H,Shen HQ,Suzuki Y,Akino T.: "Surfactant protein A accumulating in the alveoli of patients with pulmonary alveolar proteinosis : oligometric structure and interaction with lipids." Am J Respir Cell Mol Biol. 14. 608-619 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takahashi H,Kuroki Y,Honda Y,Shijubo N,Hirasawa M,Fujishima T,Akino T,Abe S.: "Lipid analysis and surfactant-associated protein expression in lungadenocarcinoma cells from pleural effusion." Respiration. 63. 390-396 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nagae N,Kuroki Y,Nagata A,Takahashi H,Honda Y,Abe S,Ogasawara Y,Akino A.: "Establishment of the enzyme-linked immunosorbent assay for pulmonary surfactant protein D in sera. (Japanese)" Med and Phamacol. 36. 803-808 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Honda Y,Takahashi H,Abe s, Yonaga K,Zeida N,Andoh M,Kondoh Y,Ogasawara Y,Kuroki Y,akino T.: "Clinical evaluation of surfactant protein D kit "Yamasa"in various lung diseases. (Japanese)" Med and Phamacol. 36. 809-815 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Honda Y,Fujiishima T,Imai Y,Takahashi H,Kuroki Y,Akino T,Abe S.: "Surfactant Protein A in bronchoalveolar lavage fluid from patients with idiopathic interstitial pneumonia. (Japanese)" 34. 1326-1330 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hattori A,Kuroki Y,Takahashi H,Sohma H,Akino T.: "Immunoglobulin G is associated with surfactant protein A aggregate isolated from patients with pulmonary alveolar proteinosis." Am J Respir Crit Care Med. 155. 1785-1788 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nagae H,Kuroki Y,Takahashi H,Honda Y,Nagata A,Ogasawara Y,Abe S,Akino T.: "Sensitive enzyme-linked immunosorbent assay improved for the detection of human pulmonary surfactant protein D in sera." Clin chim Acta. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Honda Y et al.: "Decreased contents of surfactant protein A and D in BAL fluids of healthy smoker." Chest. 109. 1006-1009 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takahashi et al.: "Lipid anilysis and surfactant-assocrated protein as pression in ling adenocarcihoma cells from pleural effusion" Respiration. 63. 390-396 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 永江尚人: "肺サーファクタント蛋白質D(SP-D)の血清濃度測定キットの開発" 医学と薬学. 36. 803-808 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 本田泰人: "肺疾患の診断における肺サーファクタント蛋白質D(SP-D)血清測定キットの有用性" 医学と薬学. 36. 809-815 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 阿部庄作: "特集:びまん性肺疾患-病態解明と治療の進歩,特発性間質性肺炎の診断と治療:トピックス:特発性間質性肺炎におけるサーファクタント蛋白質の動態と活動性の指標" 内科. 77. 664-666 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nagae H,et al.: "Sensitive enzyine-linked immunosorbent assay inproved Jor the detection of human pulmonary surfactant protein,D is sera" Clin Chim Acta. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] 阿部庄作: "間質性肺炎の病態と治療" 安藤正幸 監修,医療新社(分担執筆), 277 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Honda Y et al.: "Pulmonary Surfactant protein D in sera and bronchoalveolar lavdge fluids" Am J Respir Crit Care Med. 152. 1860-1866 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Honda Y et al.: "Decraased contents of surfactant proteins A and D in BAL fluids of healthy sinokers" CHEST. 109. 1006-1009 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 本田泰人他: "肺疾患の診断における肺サーファクタント蛋白質D(SP-D)血清濃度測定キット「ヤマサ」の有用性" 医学と薬学. 36. 809-815 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 本田泰人他: "突発性間質性肺炎における気管支肺胞洗浄液中サーファクタント蛋白質A(SP-A)値の検討" 日胸疫会誌. 34. 1326-1330 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 本田泰人: "サーファクタント蛋白質の動態とその意義-SP-A,SP-Dを中心に-" 日胸疫会誌. 34(印刷中). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 本田泰人: "サーファクタントと間質性肺疾患" 呼吸と循環. 45(印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 阿部左作他: "間質性肺炎の病態と治療" 安藤正幸監修,診療新社(分担執筆), 277 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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