| Project/Area Number |
08670672
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | SAPPORO MEDICAL UNIVERSITY |
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Principal Investigator |
TAKAHASHI Hiroki SAPPORO MEDICAL UNIVERSITY,SCHOOL OF MEDICINE,DEPARTMENT OF INTERNALMEDICINE ASSISTANT PROFESSOR, 医学部・内科学, 講師 (60231396)
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| Co-Investigator(Kenkyū-buntansha) |
KUROKI Yoshio SAPPORO MEDICAL UNIVERSITY,SCHOOL OF MEDICINE,DEPARTMENT OF BIOCHEMSTRY ASSOCIAT, 医学部・生化学, 助教授 (70161784)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1997: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | PULMONARY SURFACTANT / SURFACTANT PROTEIN A / SURFACTANT PROTEIN D / INTERSTITIAL PNEUMONIA / RADIATION PNEUMONITIS / SEROLOGICAL DIAGNOSIS |
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| Research Abstract |
(1)Eighty-eight % of patients with interstitial pneumonia (IP) which complicated by collagen vascular diseases (CDV) showed that either surfactant protein (SP)-A or SP-D in sera was higher than their cut-off levels. In contrast, only 1.8% of patients without IP showed to be false positive. These results suggest the combination assay of SP-A and SP-D predominantly improves the serological diagnosis on IP complicated by CVD.
(2)WE investigated the relationship between chest CT findings and SP-D/SP-A ratio in patients with idiopathic interstitial pneumonia (IIP). The patients were divided into two groups ; Group A showed predominantly an irregular linear opacity pattern on CT and histologicaly severe fibrosis with a weakly type II cell regeneration, Group B showed predominantly a ground-glass opacity pattern and histologicaly mild or moderate fibrosis with a prominently type II cell regeneration. As a result, Group A showed a significantly high mean value of SP-D/SP-A ratio when compared to that in group B.This suggests the heterogeneity in the rate of SP-A and SP-D production by two different cell types, type II cells and Clara cells.
(3)We next investigated the relationship between serum SP-A levels and prognosis of patients with IIP.The IIP patients who died within 3 years showed significantly high SP-A concentrations when compard to the IIP patients who had been alive more than 3 years.
(4)We also investigated the relationship wih IP comlicated by irradiation therapy. The patients came to show the increased concentrations of SP-A and SP-D in sera when IP was complicated by the received irradiation therapy. Therefore, a monitoring of the serum concentrations might be a useful tool to detect an onset of radiation pneumonitis. In the experiment using radiation-exposed rats, it was comfirmed that the incerase in sera consists with an appearance of pathohistological findings to be characteristic of IP.
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