| Project/Area Number |
08670721
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Yokohama City University School of Medicine |
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Principal Investigator |
KUROIWA Yoshiyuki Yokohama City Univ., Faculty of Medicine, Professor, 医学部, 教授 (40135249)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Junichi Nihon Medical School Faculty of Medicine, Lecturer, 医学部・附属第二病院, 講師 (00177867)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1998: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Visual Stimulus / event-related potentials / topogrphy / memory / spatial cognition / language and cognition / neurodegenertive lisease / dipole / 言語 |
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| Research Abstract |
Abstract In order to clarify whether there are characteristic changes of event-related potentials (ERPs) in parkinsonian syndromes, we studied 8 patients with progressive supranuclear palsy (PSP), 10 patients with corticobasal degeneration (CBD), 9 patients with striatonigral degeneration (SND), and 16 patients with idiopathic Parkinson's disease (PD) with a mean duration of illness of less than five years in each group. A visual oddball paradigm and a delayed matching (S 1-S2) paradigm were employed to elicit ERPs. ERPs and reaction time (RT) in each group were compared with those in the corresponding age-matched normal control group and to each other. In PSP, P300 amplitude was markedly reduced while in CBD P300 latency was prolonged during both the oddball and the S1-S2 task. No P300 abnormalities were found in the SND group or the PD group during the oddball task. However, significantly delayed N200 and reduced P300 amplitude during the S1-S2 task were found in PD but not in SND.The mean RT in the PSP and the CBD group was significantly longer than in the other two groups. These results were not due to age. Simultaneous measurement of ERPs and RT during two kinds of tasks may yield useful supplementary information in facilitating diagnosis of parkinsonian syndromes under clinical and neuroradiological criteria.
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