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Mechanism of aging in peripheral nerve

Research Project

Project/Area Number 08670737
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKinki University

Principal Investigator

KIHARA Mikihiro  Kinki University, School Medicine.Department of Neurology Associate Professor., 医学部, 助教授 (00153172)

Co-Investigator(Kenkyū-buntansha) 三井 良之  近畿大学, 医学部, 助手 (40268389)
高橋 光雄  近畿大学, 医学部, 教授 (20028492)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
KeywordsAgeing / Peripheral nerve / Nerve blood flow / Autonomic function / DM / Endothelin / Angiotensin / Noradrenalin / 抗利尿ホルモン / 水素クリアランス / 血管収縮 / 末梢神経血流量 / 局所環流 / ACE阻害剤
Research Abstract

This study examined the influence of the constricting agents (noradrenalin, endothelin I and angiotensin 2) in Spague Dawley rats aged 2 and 18 months by evaluated epineurial arteriolar vasoreactivity in response to superfused teats agents. Nerve blood flow (NBF) was measured using microelectrode H2 polarography. In 24 months rats, NBF was more decrease and vascular resistance was more increase than 2 months rats. All the constricting agents reduced NBF both group of 2 months and 18 months, however the effect of the constricting agents significant decreased with age. These results suggested that the vasomotor reactivity of noradrenalin, endothelini and angiotensin2 were modesty affected by aging.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Masaru Miyataka, Kinji Ishikawa et al: "Contralateral arterial bolus injection of 30 micrograms of basic fibroblast growth factor failed to augment myocardial blood flow in infarcted myocardium in dogs" Acta Med Kinki Univ. 21(1). 53-58 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masahiko Inagaki, Kinji Ishikawa et al: "Regional blood flow in infarcted myocardium of basic fibroblast growth factor-treated rats" Acta Med Kinki Univ. 21(1). 59-63 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 宮高 昌、石川欽司: "イヌ実験的心筋梗塞部局所心筋血流量および心筋salvage効果に及ぼす塩基性線維芽細胞増殖因子の作用" Med J Kinki Univ. 23. 65-71 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masaru Miyataka, Kinji Ishikawa et al: "Basic Fibroblast Growth Factor Increased Regional Myocardial Blood Flow and Limited Infarct Size of Acutely Infarcted Myocardium in Dogs" Angiology. 49. 381-390 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 長谷川隆弥、木村彰男、石川欽司: "家兎急性心筋梗塞における塩基性線維芽細胞増殖因子の血管新生作用および心筋壊死抑制効果" Med J Kinki Univ. (in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takaya Hasegawa, Kinji Ishiwaka: "Basic Fibroblast Growth Factor Increases Regional Myocardial Blood Flow and Salvages Myocardium in the Infarct Border Zone in a Rabbit Model of Acute Myocardial Infarction" Angiology. (in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kinji Ishikawa: "EFFECT OF BASIC FIBROBLAST GROWTH FACTOR ON THE REGIONAL MYOCARDIAL BLOOD FLOW OF ACUTELY INFARCTEDMYOCARDIUM IN EXPERIMENTAL ANIMALS" Kluwer Academic Publishers, 8 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masaru Miyataka, Kinji Ishikawa: "INTRAMYOCARDIAL INJECTION OF BASIC FIBROBLAST GROWTH FACTOR INCREASED REGIONAL MYOCARDIAL BLOOD FLOW ANDSALVAGED INFARCTED MYOCARDIUM IN DOGS" Kluwer Academic Publishers, 6 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary

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Published: 1996-04-01   Modified: 2016-04-21  

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